Hypertonic hemolysis in patients with a mood disorder.

abstract：:A "risk factor" approach to affective illness is outlined. Characteristics which are correlated with vulnerability to depression (or mania) should be sought and attempts made to either modify them or elucidate a pathophysiologic link between the characteristic and the illness. Genetic factors, biochemical factors, lif...

journal_title：Biological psychiatry

authors： Nurnberger JI Jr,Jimerson DC,Bunney WE Jr

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Chronic social defeat stress (CSDS) produces persistent behavioral adaptations in mice. In many behavioral assays, it can be difficult to determine if these adaptations reflect core signs of depression. We designed studies to characterize the effects of CSDS on sensitivity to reward because anhedonia (reduce...

journal_title：Biological psychiatry

authors： Donahue RJ,Muschamp JW,Russo SJ,Nestler EJ,Carlezon WA Jr

更新日期：2014-10-01 00:00:00

abstract：:Although much is now known about the neural basis of fear acquisition, the mechanisms of fear inhibition or suppression remain largely obscure. Fear inhibition is studied in the laboratory through the use of an extinction procedure, in which an animal (typically a rat) is exposed to nonreinforced presentations of a co...

journal_title：Biological psychiatry

authors： Davis M,Myers KM

更新日期：2002-11-15 00:00:00

abstract：BACKGROUND:In addition to cognitive impairment, there are disruptions to mood and emotion processing in attention-deficit/hyperactivity disorder (ADHD) but little is known about their neural basis. We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment wit...

journal_title：Biological psychiatry

authors： Williams LM,Hermens DF,Palmer D,Kohn M,Clarke S,Keage H,Clark CR,Gordon E

更新日期：2008-05-15 00:00:00

abstract：BACKGROUND:Perinatal maternal depression is a serious health concern with potential lasting negative consequences for children. Prenatal depression is associated with altered brain gray matter in children, though relations between postpartum depression and children's brains and the role of white matter are unclear. ME...

journal_title：Biological psychiatry

authors： Lebel C,Walton M,Letourneau N,Giesbrecht GF,Kaplan BJ,Dewey D

更新日期：2016-12-01 00:00:00

abstract：:The effect of Vincamine and Piracetam, two geriatric drugs, on sleep behavior of the laboratory cat was studied. The animals were chronically prepared for recording of the EEG of the cerebral cortex, the lateral geniculate body, and the hippocampus, and for recording of eye movements, the muscular tonus and respiratio...

journal_title：Biological psychiatry

authors： Glatt A,Klebs K,Koella WP

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Metyrapone blocks cortisol synthesis which results in removal of negative feedback, a stimulation of hypothalamic corticotropin releasing factor (CRF) and a reduction in delta sleep. We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with po...

journal_title：Biological psychiatry

authors： Otte C,Lenoci M,Metzler T,Yehuda R,Marmar CR,Neylan TC

更新日期：2007-04-15 00:00:00

abstract：BACKGROUND:Selective localization of dopamine D(4) receptors in the prefrontal cortex and preferential affinity of clozapine for the dopamine D(4) receptor over the D(2) receptor led to the hypothesis that the superior efficacy of clozapine may be mediated via blockade of the D(4) receptor. This hypothesis was tested b...

journal_title：Biological psychiatry

authors： Corrigan MH,Gallen CC,Bonura ML,Merchant KM,Sonepiprazole Study Group.

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Preclinical studies demonstrate that 17beta-estradiol (E(2)) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. METHODS:We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [(18)F]altanserin in five postm...

journal_title：Biological psychiatry

authors： Moses EL,Drevets WC,Smith G,Mathis CA,Kalro BN,Butters MA,Leondires MP,Greer PJ,Lopresti B,Loucks TL,Berga SL

更新日期：2000-10-15 00:00:00

abstract：:Defatted breast milk from women with postpartum psychosis and from healthy lactating women was analyzed by high-resolution gel permeation chromatography as well as by sodium dodecyl sulfate (SDS) and urea polyacrylamide gel electrophoresis. The gel permeation procedure allowed quantitative analysis of milk proteins (i...

journal_title：Biological psychiatry

authors： Nyberg F,Lindström LH,Terenius L

更新日期：1988-01-15 00:00:00

abstract：:Sleep homeostasis and circadian function are important maintaining factors for optimal health and well-being. Conversely, sleep and circadian disruptions are implicated in a variety of adverse health outcomes, including substance use disorders. These risks are particularly salient during adolescence. Adolescents requi...

journal_title：Biological psychiatry

authors： Logan RW,Hasler BP,Forbes EE,Franzen PL,Torregrossa MM,Huang YH,Buysse DJ,Clark DB,McClung CA

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose ...

journal_title：Biological psychiatry

authors： Kurth F,Narr KL,Woods RP,O'Neill J,Alger JR,Caplan R,McCracken JT,Toga AW,Levitt JG

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. METHODS:Thirteen drug-free...

journal_title：Biological psychiatry

authors： Sallee FR,Vrindavanam NS,Deas-Nesmith D,Odom AM,Carson SW,Sethuraman G

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Like fear conditioning, the acquisition phase of extinction involves new learning that is mediated by the amygdala. During extinction training, the conditioned stimulus is repeatedly presented in the absence of the unconditioned stimulus, and the expression of previously learned fear gradually becomes suppre...

journal_title：Biological psychiatry

authors： Burghardt NS,Sigurdsson T,Gorman JM,McEwen BS,LeDoux JE

更新日期：2013-06-01 00:00:00

abstract：:There is substantial evidence that depression is a risk factor for cardiac morbidity and mortality, both for patients without clinical evidence of coronary heart disease at index examination and for patients with established coronary disease. The relationship is most apparent for patients with a recent acute myocardia...

journal_title：Biological psychiatry

authors： Carney RM,Freedland KE

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Suvorexant is an orexin receptor antagonist for treatment of insomnia. We report results from two pivotal phase 3 trials. METHODS:Two randomized, double-blind, placebo-controlled, parallel-group, 3-month trials in nonelderly (18-64 years) and elderly (≥65 years) patients with insomnia. Suvorexant doses of 4...

journal_title：Biological psychiatry

authors： Herring WJ,Connor KM,Ivgy-May N,Snyder E,Liu K,Snavely DB,Krystal AD,Walsh JK,Benca RM,Rosenberg R,Sangal RB,Budd K,Hutzelmann J,Leibensperger H,Froman S,Lines C,Roth T,Michelson D

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Previous neuroimaging studies have demonstrated exaggerated amygdala responses to negative stimuli in posttraumatic stress disorder (PTSD). The time course of this amygdala response is largely unstudied and is relevant to questions of habituation and sensitization in PTSD exposure therapy. METHODS:We applie...

journal_title：Biological psychiatry

authors： Protopopescu X,Pan H,Tuescher O,Cloitre M,Goldstein M,Engelien W,Epstein J,Yang Y,Gorman J,LeDoux J,Silbersweig D,Stern E

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening. In spite of the remarkable progress in understanding the neural biology, the etiopathophysiology of depression is still elusive. In this study, we have investigated molecular mechanisms in the prefrontal cortex ...

journal_title：Biological psychiatry

authors： Veeraiah P,Noronha JM,Maitra S,Bagga P,Khandelwal N,Chakravarty S,Kumar A,Patel AB

更新日期：2014-08-01 00:00:00

abstract：:Psychomotor retardation is a frequently observed clinical feature of depressive states. This study attempted to assess the relationship between response slowness and central nervous system (CNS) activity by examining cortical evoked potentials (EPs) during psychomotor task performance. Patients consisted of 21 women w...

journal_title：Biological psychiatry

authors： Knott VJ,Lapierre YD

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:The ability to spontaneously attend to the social overtures and activities of others is essential for the development of social cognition and communication. This ability is critically impaired in toddlers with autism spectrum disorders (ASD); however, it is not clear if prodromal symptoms in this area are al...

journal_title：Biological psychiatry

authors： Chawarska K,Macari S,Shic F

更新日期：2013-08-01 00:00:00

abstract：:Over the last decade, transcriptome studies of postmortem tissue from subjects with schizophrenia revealed that synaptic, mitochondrial, immune system, gamma-aminobutyric acidergic, and oligodendrocytic changes are all integral parts of the disease process. The combined genetic and transcriptomic studies argue that th...

journal_title：Biological psychiatry

authors： Horváth S,Mirnics K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Studies in elderly patients demonstrate antipsychotic efficacy and favorable safety profiles for olanzapine. We report results from two placebo-controlled, double-blind studies of olanzapine for treatment of dopamimetic drug-induced psychosis in patients with Parkinson's disease (PD). METHODS:Patients were ...

journal_title：Biological psychiatry

authors： Breier A,Sutton VK,Feldman PD,Kadam DL,Ferchland I,Wright P,Friedman JH

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Relations between stress hormones and antisocial behavior are understudied. METHODS:A subsample (n = 335) of at-risk males recruited in first grade for a longitudinal study were recruited at approximately 16 years of age for a laboratory study, including two psychological challenges: describing their worst ...

journal_title：Biological psychiatry

authors： McBurnett K,Raine A,Stouthamer-Loeber M,Loeber R,Kumar AM,Kumar M,Lahey BB

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders. METHODS:With real-time quantitative polymerase chain reaction, we compared the expre...

journal_title：Biological psychiatry

authors： Moreau MP,Bruse SE,David-Rus R,Buyske S,Brzustowicz LM

更新日期：2011-01-15 00:00:00

abstract：:The effect of oral contraceptive use and hospitalization stress on the results of the dexamethasone suppression test (DST) were assessed. This test, in which 1 mg dexamethasone is given at 11:00 p.m., and blood cortisol is analyzed the following day, is used as an indicator or major or endogenous depression, as oppos...

journal_title：Biological psychiatry

authors： D'haenen H,de Weert D,Ansseau M

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Monoamine oxidase (MAO) is a critical enzyme in deamination of biogenic amines and may be involved in the pathophysiology of major psychosis, including mood disorder and schizophrenia. Recently, evidence for genetic association between the MAO-A gene and bipolar mood disorder was obtained in Caucasians. MET...

journal_title：Biological psychiatry

authors： Sasaki T,Hattori M,Sakai T,Kato T,Kunugi H,Hirose T,Nanko S

更新日期：1998-11-01 00:00:00

abstract：:Research on mood and anxiety disorders has historically proceeded without sufficient reference to the growing body of work on the nature of typical emotional development and temperament. Reviewing data from several studies, we consider experiential, biological, and genetic factors as providing causal input to typical ...

journal_title：Biological psychiatry

authors： Goldsmith HH,Lemery KS

更新日期：2000-12-15 00:00:00

abstract：BACKGROUND:Oculomotor tasks are a well-established means of studying executive functions and frontal-striatal functioning in both nonhuman primates and humans. Attention-deficit/hyperactivity disorder (ADHD) is thought to implicate frontal-striatal circuitry. We used oculomotor tests to investigate executive functions ...

journal_title：Biological psychiatry

authors： O'Driscoll GA,Dépatie L,Holahan AL,Savion-Lemieux T,Barr RG,Jolicoeur C,Douglas VI

更新日期：2005-06-01 00:00:00

abstract：:Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the fin...

journal_title：Biological psychiatry

authors： Gage SH,Hickman M,Zammit S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:In this study we extended previous work by examining whether disturbances in the circadian rhythms of cortisol during the menstrual cycle distinguish patients with premenstrual dysphoric disorder (PMDD) from normal control (NC) subjects. In addition, we tested the differential response to the effects of earl...

journal_title：Biological psychiatry

authors： Parry BL,Javeed S,Laughlin GA,Hauger R,Clopton P

更新日期：2000-11-01 00:00:00