Abstract：
BACKGROUND:Preclinical studies demonstrate that 17beta-estradiol (E(2)) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. METHODS:We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [(18)F]altanserin in five postmenopausal women. Subjects were imaged at baseline, following 8 to 14 weeks of transdermal E(2), 0.1 mg/d, and following 2 to 6 weeks of E(2) plus micronized progesterone (P) 100 mg per os twice daily. Regional BPs in the anterior cingulate cortex, dorsolateral prefrontal cortex, and lateral orbitofrontal cortex were calculated by Logan analysis. RESULTS:There was a main effect of time (p = .017) for 5-HT(2A)R BP, which increased 21.2%+/-2.6% following combined E(2) and P administration relative to baseline. This effect was evident in all cerebral cortex regions examined. CONCLUSIONS:5-HT(2A)R BP increased in widespread areas of the cerebral cortex following combined E(2) + P administration.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Moses EL,Drevets WC,Smith G,Mathis CA,Kalro BN,Butters MA,Leondires MP,Greer PJ,Lopresti B,Loucks TL,Berga SLdoi
10.1016/s0006-3223(00)00967-7subject
Has Abstractpub_date
2000-10-15 00:00:00pages
854-60issue
8eissn
0006-3223issn
1873-2402pii
S0006-3223(00)00967-7journal_volume
48pub_type
杂志文章abstract：BACKGROUND:Personality traits are associated with substance dependence (SD); genetic factors may influence both. Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study. METHODS:We assessed dimensi...
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journal_title：Biological psychiatry
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