Abstract：
BACKGROUND:Clinical and animal studies suggest that brain serotonergic systems may regulate aggressive behavior; however, the serotonin/violence hypothesis has not been assessed at the epidemiological level. For study of an epidemiological sample we examined blood serotonin, because certain physiological and behavioral findings suggested that it might serve as an analog marker for serotonergic function. METHODS:Whole blood serotonin was measured in a representative birth cohort of 781 21-year-old women (47%) and men (53%). Violence was measured using cumulative court conviction records and participants' self-reports. Potential intervening factors addressed were: gender, age, diurnal variation, diet, psychiatric medications, illicit drug history, season of phlebotomy, plasma tryptophan, platelet count, body mass, suicide attempts, psychiatric diagnoses, alcohol, tobacco, socioeconomic status, IQ, and overall criminal offending. RESULTS:Whole blood serotonin related to violence among men but not women. Violent men's mean blood serotonin level was 0.48 SD above the male population norm and 0.56 SD above the mean of nonviolent men. The finding was specific to violence, as opposed to general crime, and it was robust across two different methods of measuring violence. Together, the intervening variables accounted for 25% of the relation between blood serotonin and violence. CONCLUSIONS:To our knowledge, this is the first demonstration that an index of serotonergic function is related to violence in the general population.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Moffitt TE,Brammer GL,Caspi A,Fawcett JP,Raleigh M,Yuwiler A,Silva Pdoi
10.1016/s0006-3223(97)00340-5subject
Has Abstractpub_date
1998-03-15 00:00:00pages
446-57issue
6eissn
0006-3223issn
1873-2402pii
S0006322397003405journal_volume
43pub_type
临床试验,杂志文章abstract：BACKGROUND:Proton magnetic resonance spectroscopy was used to determine the effects of intravenous cocaine or placebo administration on human basal ganglia water and metabolite resonances. METHODS:Long echo time, proton magnetic resonance spectra of water and intracellular metabolites were continuously acquired from a...
journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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