Abstract：
BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder without validated objective markers. Eye movement studies may be useful in providing objective criteria for characterizing the disorder. METHODS:We compared 53 children (29 girls) with ADHD to 44 healthy control children (18 girls) on a 21-sec fixation task. Large saccades (> 4 degrees ) away from the fixation point were analyzed. RESULTS:Children with ADHD made more large saccades that interrupted fixation than did control children (p =.001). Mean scores of the ADHD group did not change significantly with subsequent retesting on placebo (p =.11); however, there was poor intrasubject correlation (r =.16). CONCLUSIONS:Both boys and girls with ADHD made significantly more intrusive saccades during fixation than did control subjects, possibly reflecting intrinsic neurologic dysfunction; however, a probable "floor effect" obviates conclusions about the reliability of this measure.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Gould TD,Bastain TM,Israel ME,Hommer DW,Castellanos FXdoi
10.1016/s0006-3223(01)01095-2subject
Has Abstractpub_date
2001-10-15 00:00:00pages
633-5issue
8eissn
0006-3223issn
1873-2402pii
S0006322301010952journal_volume
50pub_type
杂志文章abstract：BACKGROUND:GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology. The receptor is also expressed in other brain areas, and here we examined whether GPR88 function extends beyond striatal-mediated responses. METHODS:We c...
journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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journal_title：Biological psychiatry
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pub_type： 杂志文章
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2009-07-15 00:00:00
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pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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doi：10.1016/j.biopsych.2004.03.018
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journal_title：Biological psychiatry
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doi：
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2013-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：1998-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.10.009
更新日期：2014-08-01 00:00:00
