当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Norepinephrine activates extracellular-regulated kinase in cortical neurons.

Norepinephrine activates extracellular-regulated kinase in cortical neurons.

Abstract：

BACKGROUND:Previous studies demonstrate that indirect activation of monoamine receptors by antidepressant treatment increases neurotrophic factors that activate the mitogen-activated protein kinase cascade; however, it is also possible that these monoamine receptors influence the mitogen-activated protein kinase pathway independent of neurotrophic factors. The influence of norepinephrine on the phosphorylation of extracellular-regulated protein kinase is characterized. METHODS:Primary cerebral cortical cultures were prepared from embryonic day 18 rat brains and were subsequently incubated with norepinephrine in the absence or presence of agents acting as noradrenergic receptors or as intracellular signaling proteins. Levels of phosphorylated extracellular-regulated protein kinase were determined by immunoblot. RESULTS:The results demonstrate that incubation with norepinephrine produces a time- and dose-dependent activation of phosphorylated extracellular-regulated protein kinase and that this increase is dependent on activation of alpha(2)- and beta-adrenergic receptor subtypes. In addition, the results demonstrate that norepinephrine activation of phosphorylated extracellular-regulated protein kinase is dependent on a pertussis toxin-sensitive G protein, a receptor tyrosine kinase, and activation of phosphatidylinositol 3-kinase. CONCLUSIONS:The findings suggest that activation of the mitogen-activated protein kinase cascade by norepinephrine can occur via a tyrosine kinase-dependent signaling pathway but independent of classical second-messenger or Src-dependent kinases.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Tolbert LM,Russell DS,Duman RS

doi

10.1016/s0006-3223(03)00346-9

subject

Has Abstract

pub_date

2003-11-15 00:00:00

pages

983-93

issue

10

eissn

0006-3223

issn

1873-2402

pii

S0006322303003469

journal_volume

54

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Approaches to Defining Common and Dissociable Neurobiological Deficits Associated With Psychopathology in Youth.

    abstract：:Psychiatric disorders show high rates of comorbidity and nonspecificity of presenting clinical symptoms, while demonstrating substantial heterogeneity within diagnostic categories. Notably, many of these psychiatric disorders first manifest in youth. We review progress and next steps in efforts to parse heterogeneity ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2019.12.015

    authors： Kaczkurkin AN,Moore TM,Sotiras A,Xia CH,Shinohara RT,Satterthwaite TD

    更新日期：2020-07-01 00:00:00

  • A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia.

    abstract：BACKGROUND:Synapsin III plays a role in neuronal plasticity and maps to chromosome 22q12-13, a region suggested to be linked to schizophrenia. To determine if synapsin III plays a role in this disease, we searched for polymorphisms in this gene in patients with schizophrenia and controls. METHODS:The synapsin III gene...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2003.07.002

    authors： Porton B,Ferreira A,DeLisi LE,Kao HT

    更新日期：2004-01-15 00:00:00

  • Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.

    abstract：BACKGOUND:Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential rol...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.01.026

    authors： Ben Hamida S,Mendonça-Netto S,Arefin TM,Nasseef MT,Boulos LJ,McNicholas M,Ehrlich AT,Clarke E,Moquin L,Gratton A,Darcq E,Harsan LA,Maldonado R,Kieffer BL

    更新日期：2018-08-01 00:00:00

  • Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood.

    abstract：BACKGROUND:Considering the magnitude of the reported changes in brain volume over time in first-episode patients it is unlikely that these changes are constant over the life-span of the schizophrenic illness. Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex traject...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.01.004

    authors： van Haren NE,Hulshoff Pol HE,Schnack HG,Cahn W,Brans R,Carati I,Rais M,Kahn RS

    更新日期：2008-01-01 00:00:00

  • Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events.

    abstract：BACKGROUND:Recently, it has been reported that serum interleukin-1 beta (IL-1 beta), but not soluble IL-2 receptor (sIL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00131-0

    authors： Maes M,Lin AH,Delmeire L,Van Gastel A,Kenis G,De Jongh R,Bosmans E

    更新日期：1999-04-01 00:00:00

  • Regional cerebral glucose metabolic abnormalities in bipolar II depression.

    abstract：BACKGROUND:Functional neuroimaging studies of bipolar disorder (BD) performed in conjunction with antidepressant treatment trials generally require that patients remain on mood stabilizers to reduce the risk of inducing mania; yet, it is unknown whether the metabolic abnormalities evident in unmedicated BD depressives ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.06.009

    authors： Mah L,Zarate CA Jr,Singh J,Duan YF,Luckenbaugh DA,Manji HK,Drevets WC

    更新日期：2007-03-15 00:00:00

  • Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet.

    abstract：BACKGROUND:Sensitivity to reward has been implicated as a predisposing factor for behaviors related to drug abuse as well as overeating. However, the underlying mechanisms contributing to reward sensitivity are unknown. We hypothesized that a dysregulation in dopamine signaling might be an underlying cause of heightene...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.06.007

    authors： Teegarden SL,Nestler EJ,Bale TL

    更新日期：2008-12-01 00:00:00

  • The effect of tricyclic antidepressants on cerebral fluid dynamics.

    abstract：:Tricyclic antidepressants are thought to act primarily via effects on adrenergic neurotransmitters. Recent research supports the concept that a major function of the central adrenergic system is the modulation of cerebral fluid dynamics. Based on this concept, studies in the rat were conducted to assess the effects of...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Preskorn SH,Hartman BK

    更新日期：1979-04-01 00:00:00

  • Effect of alpha-methyl-para-tyrosine on response to cocaine challenge.

    abstract：:This study evaluated the effect of an acute reduction in catecholamine synthesis produced by alpha-methyl-para-tyrosine (AMPT), a tyrosine hydroxylase inhibitor, on cocaine-induced euphoria. In a blinded, placebo-controlled study, AMPT (1 g p.o. T.I.D.) was given to 10 non-treatment-seeking cocaine abusers prior to in...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(96)00331-9

    authors： Stine SM,Krystal JH,Petrakis IL,Jatlow PI,Heninger GR,Kosten TR,Charney DS

    更新日期：1997-08-01 00:00:00

  • In search of multimodal neuroimaging biomarkers of cognitive deficits in schizophrenia.

    abstract：BACKGROUND:The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across ma...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.02.017

    authors： Sui J,Pearlson GD,Du Y,Yu Q,Jones TR,Chen J,Jiang T,Bustillo J,Calhoun VD

    更新日期：2015-12-01 00:00:00

  • Effects of neuroleptics on platelet monoamine oxidase activity.

    abstract：:Platelet MAO activity in schizophrenics was significantly decreased, by about 15%, after 3 weeks of treatment with haloperidol. Treatment with thioridazine or butaperazine also tended to decrease platelet MAO activity. The neuroleptic-induced decrease began to appear within a few days of treatment and did not show tol...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Ho BT,Smith RC,Kralik P,Allen R,Schoolar J,Khan M,DeJohn C

    更新日期：1982-08-01 00:00:00

  • Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants.

    abstract：BACKGROUND:Because researchers have reported that antidepressants increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus, we investigated whether serum BDNF levels may be used as a putative biological marker for major depressive disorders (MDD). METHODS:We measured serum BDNF in the...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00181-1

    authors： Shimizu E,Hashimoto K,Okamura N,Koike K,Komatsu N,Kumakiri C,Nakazato M,Watanabe H,Shinoda N,Okada S,Iyo M

    更新日期：2003-07-01 00:00:00

  • Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse.

    abstract：BACKGROUND:Chromatin remodeling, including changes in histone acetylation, might play a role in the pathophysiology and treatment of depression. We investigated whether the histone deacetylase inhibitor sodium butyrate (SB) administered as single drug or in combination with the selective serotonin reuptake inhibitor (S...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.06.036

    authors： Schroeder FA,Lin CL,Crusio WE,Akbarian S

    更新日期：2007-07-01 00:00:00

  • Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia.

    abstract：:There is increasing evidence of a deficit or disturbance of neurons in the brains of schizophrenic patients--evidence that particularly implicates the frontal or temporal lobes. As yet there is no direct neurochemical correlate of the transmitter systems involved, although changes in some neurotransmitters in the temp...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(90)90039-5

    authors： Reynolds GP,Czudek C,Andrews HB

    更新日期：1990-05-01 00:00:00

  • Association between amino acid alterations and hallucinations in alcoholic patients.

    abstract：:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90175-1

    authors： Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

    更新日期：1985-11-01 00:00:00

  • Relative risk for cognitive impairments in siblings of patients with schizophrenia.

    abstract：BACKGROUND:Patients with schizophrenia have impairments in several domains of cognition, including working memory/executive function, verbal memory, language, oculomotor scanning/psychomotor speed, and general intelligence. Impairments have also been found in unaffected siblings, suggesting they could be heritable. To ...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(01)01133-7

    authors： Egan MF,Goldberg TE,Gscheidle T,Weirich M,Rawlings R,Hyde TM,Bigelow L,Weinberger DR

    更新日期：2001-07-15 00:00:00

  • Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.

    abstract：BACKGROUND:Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPα, in the control of radial neuronal migration, cortical cytoarchitecture, and oligod...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.06.016

    authors： Takahashi N,Nielsen KS,Aleksic B,Petersen S,Ikeda M,Kushima I,Vacaresse N,Ujike H,Iwata N,Dubreuil V,Mirza N,Sakurai T,Ozaki N,Buxbaum JD,Sap J

    更新日期：2011-10-01 00:00:00

  • The Effects of β-Adrenergic Blockade on the Degrading Effects of Eye Movements on Negative Autobiographical Memories.

    abstract：BACKGROUND:Eye movement desensitization and reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder. During EMDR, patients make horizontal eye movements (EMs) while simultaneously recalling a traumatic memory, which renders the memory less vivid and emotional when it is later recalled again. Rec...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2017.03.012

    authors： Littel M,Kenemans JL,Baas JMP,Logemann HNA,Rijken N,Remijn M,Hassink RJ,Engelhard IM,van den Hout MA

    更新日期：2017-10-15 00:00:00

  • Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.

    abstract：BACKGROUND:GPR88 is an orphan G protein coupled receptor highly enriched in the striatum, and previous studies have focused on GPR88 function in striatal physiology. The receptor is also expressed in other brain areas, and here we examined whether GPR88 function extends beyond striatal-mediated responses. METHODS:We c...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.05.020

    authors： Meirsman AC,Le Merrer J,Pellissier LP,Diaz J,Clesse D,Kieffer BL,Becker JA

    更新日期：2016-06-01 00:00:00

  • Kinetics and Dose Dependency of Intranasal Oxytocin Effects on Amygdala Reactivity.

    abstract：BACKGROUND:Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2017.04.015

    authors： Spengler FB,Schultz J,Scheele D,Essel M,Maier W,Heinrichs M,Hurlemann R

    更新日期：2017-12-15 00:00:00

  • Efficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/hyperactivity disorder.

    abstract：BACKGROUND:This multicenter, randomized, fixed-dose, double-blind, placebo-controlled study evaluated efficacy of extended-release dexmethylphenidate (d-MPH-ER) in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS:Randomized adults with ADHD (n=221) received once-daily d-MPH-ER 20 mg, 30 mg, or 40 m...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.biopsych.2006.07.032

    authors： Spencer TJ,Adler LA,McGough JJ,Muniz R,Jiang H,Pestreich L,Adult ADHD Research Group.

    更新日期：2007-06-15 00:00:00

  • A family study of unsocialized aggressive boys.

    abstract：:The psychiatric histories of relatives of 17 boys admitted to an inpatient unit with "unsocialized aggressive" behavior and of 19 boys admitted with other problems were investigated by means of structured interviews. The interviews were rated blind and diagnoses made on the respondents and relatives described in the f...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Stewart MA,Leone L

    更新日期：1978-02-01 00:00:00

  • The serotonin transporter in the midbrain of suicide victims with major depression.

    abstract：BACKGROUND:The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. The midbrain dorsal raph...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(99)00313-3

    authors： Bligh-Glover W,Kolli TN,Shapiro-Kulnane L,Dilley GE,Friedman L,Balraj E,Rajkowska G,Stockmeier CA

    更新日期：2000-06-15 00:00:00

  • Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study.

    abstract：BACKGROUND:Preclinical studies demonstrate that 17beta-estradiol (E(2)) increases serotonin-2A receptor (5-HT(2A)R) density in rat frontal cortex. METHODS:We investigated the impact of hormone replacement therapy on 5-HT(2A)R binding potential (BP) using positron emission tomography and [(18)F]altanserin in five postm...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(00)00967-7

    authors： Moses EL,Drevets WC,Smith G,Mathis CA,Kalro BN,Butters MA,Leondires MP,Greer PJ,Lopresti B,Loucks TL,Berga SL

    更新日期：2000-10-15 00:00:00

  • CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia.

    abstract：BACKGROUND:Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. METHODS:Associations were investigated between CAG repeat length and gender, age of illness onset, and psych...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00033-5

    authors： Cardno AG,Bowen T,Guy CA,Jones LA,McCarthy G,Williams NM,Murphy KC,Spurlock G,Gray M,Sanders RD,Craddock N,McGuffin P,Owen MJ,O'Donovan MC

    更新日期：1999-06-15 00:00:00

  • Antipsychotic drugs and plasma vasopressin in normals and acute schizophrenic patients.

    abstract：:Elevated plasma vasopressin concentrations have been documented in antipsychotic drug-treated patients as well as a drug-free acutely psychotic patients. To evaluate the effects of antipsychotic drugs on plasma vasopressin, we measured vasopressin response to a single dose of intramuscular chlorpromazine or intravenou...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(87)90167-3

    authors： Raskind MA,Courtney N,Murburg MM,Backus FI,Bokan JA,Ries RK,Dorsa DM,Weitzman RE

    更新日期：1987-04-01 00:00:00

  • The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: a meta-analysis.

    abstract：BACKGROUND:We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders. METHODS:DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.biopsych.2005.01.030

    authors： López León S,Croes EA,Sayed-Tabatabaei FA,Claes S,Van Broeckhoven C,van Duijn CM

    更新日期：2005-05-01 00:00:00

  • Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia.

    abstract：BACKGROUND:Previous studies suggest circadian rhythm disturbances in children with attention-deficit/hyperactivity disorder (ADHD) and sleep-onset insomnia (SOI). We investigate here sleep and rhythms in activity and melatonin in adults with ADHD. METHODS:Sleep logs and actigraphy data were collected during 1 week in ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.12.032

    authors： Van Veen MM,Kooij JJ,Boonstra AM,Gordijn MC,Van Someren EJ

    更新日期：2010-06-01 00:00:00

  • Cortex, white matter, and basal ganglia in schizophrenia: a volumetric postmortem study.

    abstract：:Postmortem volumetry of cortex, white matter, and basal ganglia was performed in 23 brains of schizophrenic patients and 23 brains of controls closely matched for gender, age, and hemisphere. Stereological methods were applied to serial coronal sections of complete hemispheres. We found no significant volume changes o...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90091-y

    authors： Heckers S,Heinsen H,Heinsen Y,Beckmann H

    更新日期：1991-03-15 00:00:00

  • Neural correlates of negative emotionality in borderline personality disorder: an activation-likelihood-estimation meta-analysis.

    abstract：BACKGROUND:Emotional vulnerabilities at the core of borderline personality disorder (BPD) involve a dysfunction of frontolimbic systems subserving negative emotionality. The specific regions identified in individual studies, however, vary widely and provide an incomplete understanding of the functional brain abnormalit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.biopsych.2012.07.014

    authors： Ruocco AC,Amirthavasagam S,Choi-Kain LW,McMain SF

    更新日期：2013-01-15 00:00:00