Abstract：
BACKGROUND:The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. The midbrain dorsal raphe nucleus (DR) has been implicated as a site for diminished serotonergic activity in that suicide victims with major depression have a significant increase in serotonin-1A autoreceptors in the DR. METHODS:[(3)H]Paroxetine was used to label the serotonin transporter in the subnuclei of the DR at several rostral-to-caudal levels of the midbrain in ten pairs of suicide victims with major depression and age-matched psychiatrically normal control subjects. RESULTS:There was a significant increase in serotonin transporters in the entire DR progressing from rostral-to-caudal levels in both normal control subjects and suicide victims with major depression. At comparable rostral-to-caudal levels, there were no significant differences in [(3)H]paroxetine binding between depressed suicide victims and normal control subjects in either the entire DR or its constituent subnuclei. CONCLUSIONS:The pathophysiology of serotonin mechanisms in suicide victims with major depression does not appear to involve alterations in the binding of [(3)H]paroxetine to the serotonin transporter in the midbrain DR.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Bligh-Glover W,Kolli TN,Shapiro-Kulnane L,Dilley GE,Friedman L,Balraj E,Rajkowska G,Stockmeier CAdoi
10.1016/s0006-3223(99)00313-3subject
Has Abstractpub_date
2000-06-15 00:00:00pages
1015-24issue
12eissn
0006-3223issn
1873-2402pii
S0006322399003133journal_volume
47pub_type
临床试验,杂志文章abstract：BACKGROUND:Inositol has been reported to be an effective treatment in depression, and we hypothesized that inositol addition might enhance or speed up response to serotonin selective reuptake inhibitors (SSRI). METHODS:Twenty-seven depressed patients completed a double-blind controlled 4-week trial of SSRI plus placeb...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1999-02-01 00:00:00
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journal_title：Biological psychiatry
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更新日期：2003-11-15 00:00:00
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pub_type： 杂志文章
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更新日期：1993-09-01 00:00:00
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journal_title：Biological psychiatry
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更新日期：1979-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-06-15 00:00:00
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更新日期：2010-08-15 00:00:00
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更新日期：1993-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
