Abstract：
:Sleep homeostasis and circadian function are important maintaining factors for optimal health and well-being. Conversely, sleep and circadian disruptions are implicated in a variety of adverse health outcomes, including substance use disorders. These risks are particularly salient during adolescence. Adolescents require 8 to 10 hours of sleep per night, although few consistently achieve these durations. A mismatch between developmental changes and social/environmental demands contributes to inadequate sleep. Homeostatic sleep drive takes longer to build, circadian rhythms naturally become delayed, and sensitivity to the phase-shifting effects of light increases, all of which lead to an evening preference (i.e., chronotype) during adolescence. In addition, school start times are often earlier in adolescence and the use of electronic devices at night increases, leading to disrupted sleep and circadian misalignment (i.e., social jet lag). Social factors (e.g., peer influence) and school demands further impact sleep and circadian rhythms. To cope with sleepiness, many teens regularly consume highly caffeinated energy drinks and other stimulants, creating further disruptions in sleep. Chronic sleep loss and circadian misalignment enhance developmental tendencies toward increased reward sensitivity and impulsivity, increasing the likelihood of engaging in risky behaviors and exacerbating the vulnerability to substance use and substance use disorders. We review the neurobiology of brain reward systems and the impact of sleep and circadian rhythms changes on addiction vulnerability in adolescence and suggest areas that warrant additional research.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Logan RW,Hasler BP,Forbes EE,Franzen PL,Torregrossa MM,Huang YH,Buysse DJ,Clark DB,McClung CAdoi
10.1016/j.biopsych.2017.11.035subject
Has Abstractpub_date
2018-06-15 00:00:00pages
987-996issue
12eissn
0006-3223issn
1873-2402pii
S0006-3223(17)32285-0journal_volume
83pub_type
杂志文章,评审abstract：BACKGROUND:Suvorexant is an orexin receptor antagonist for treatment of insomnia. We report results from two pivotal phase 3 trials. METHODS:Two randomized, double-blind, placebo-controlled, parallel-group, 3-month trials in nonelderly (18-64 years) and elderly (≥65 years) patients with insomnia. Suvorexant doses of 4...
journal_title：Biological psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-01-15 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1991-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.05.017
更新日期：2007-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90143-n
更新日期：1992-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1990-06-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2007-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1999-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1992-04-15 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2006-07-15 00:00:00
