当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Efficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/hyperactivity disorder.

Efficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/hyperactivity disorder.

Abstract：

BACKGROUND:This multicenter, randomized, fixed-dose, double-blind, placebo-controlled study evaluated efficacy of extended-release dexmethylphenidate (d-MPH-ER) in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS:Randomized adults with ADHD (n=221) received once-daily d-MPH-ER 20 mg, 30 mg, or 40 mg or placebo for 5 weeks. The primary efficacy variable was change from baseline to final visit in DSM-IV ADHD Rating Scale (ADHD-RS) total score. Secondary efficacy parameters included the proportion of patients with improvement>or=30% in ADHD-RS total score and final scores on Clinical Global Impressions-Improvement (CGI-I) scale. RESULTS:Of 218 evaluable patients, 184 completed the study. All d-MPH-ER doses were significantly superior to placebo in improving ADHD-RS total scores. Placebo scores improved by 7.9; d-MPH-ER, 20 mg, improved by 13.7 (p=.006); d-MPH-ER, 30 mg, improved by 13.4 (p=.012); and d-MPH-ER, 40 mg, improved by 16.9 (p<.001). Overall distribution of CGI-I ratings at final visit was significantly better with each d-MPH-ER dosage than with placebo. There were no unexpected safety or tolerability concerns, based on experience with racemic methylphenidate (MPH) in adults and dexmethylphenidate (d-MPH) in children. CONCLUSIONS:Once-daily d-MPH-ER at 20 mg, 30 mg, or 40 mg is a safe and effective treatment for adults with ADHD.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Spencer TJ,Adler LA,McGough JJ,Muniz R,Jiang H,Pestreich L,Adult ADHD Research Group.

doi

10.1016/j.biopsych.2006.07.032

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

1380-7

issue

12

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)00954-1

journal_volume

61

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks.

    abstract：BACKGROUND:Although genetic risk factors for posttraumatic stress disorder (PTSD) in similarly traumatized cohorts can be confounded with risk for type of exposure, the primary risk for exposure to the 9/11 attack on New York City was proximity, allowing study of PTSD risk in a sample that is not confounded by exposure...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.02.034

    authors： Yehuda R,Cai G,Golier JA,Sarapas C,Galea S,Ising M,Rein T,Schmeidler J,Müller-Myhsok B,Holsboer F,Buxbaum JD

    更新日期：2009-10-01 00:00:00

  • Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting.

    abstract：BACKGROUND:The study of Turner syndrome (TS) offers a unique window of opportunity for advancing scientific knowledge of how X chromosome gene imprinting, epigenetic factors, hormonal milieu, and chronologic age affect brain development in females. METHODS:We described brain growth trajectories in 55 girls with TS and...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.07.032

    authors： O'Donoghue S,Green T,Ross JL,Hallmayer J,Lin X,Jo B,Huffman LC,Hong DS,Reiss AL

    更新日期：2020-01-15 00:00:00

  • Striatal enlargement in rats chronically treated with neuroleptic.

    abstract：BACKGROUND:Striatal enlargement with chronic neuroleptic treatment in schizophrenic patients has been reported by several investigators. Longitudinal magnetic resonance imaging studies of patients suggest that changes in striatal volume may be caused by treatment with antipsychotic medication. METHODS:We have examined...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00029-8

    authors： Chakos MH,Shirakawa O,Lieberman J,Lee H,Bilder R,Tamminga CA

    更新日期：1998-10-15 00:00:00

  • Sensory gating in schizophrenia: P50 and N100 gating in antipsychotic-free subjects at risk, first-episode, and chronic patients.

    abstract：BACKGROUND:Abnormal sensory gating in schizophrenia has frequently been reported; however, only limited data on unmedicated patients and patients at risk to develop a psychosis have, as yet, been available. METHODS:P50 and N100 suppression were assessed with an auditory double-click paradigm in five groups: 18 at-risk...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.02.006

    authors： Brockhaus-Dumke A,Schultze-Lutter F,Mueller R,Tendolkar I,Bechdolf A,Pukrop R,Klosterkoetter J,Ruhrmann S

    更新日期：2008-09-01 00:00:00

  • Limbic pathology in schizophrenia: the entorhinal region--a morphometric study.

    abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(88)90162-x

    authors： Falkai P,Bogerts B,Rozumek M

    更新日期：1988-09-01 00:00:00

  • Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder.

    abstract：BACKGROUND:The hippocampus (HC) is smaller in patients with recurrent major depressive disorder (MDD), but few longitudinal studies have examined whether volume is associated with clinically meaningful outcomes such as response to treatment. METHODS:We compared regional (head and body/tail) HC volumes in 46 patients w...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.06.027

    authors： MacQueen GM,Yucel K,Taylor VH,Macdonald K,Joffe R

    更新日期：2008-11-15 00:00:00

  • Pharmacotherapy of depressed children and adolescents: current issues and potential directions.

    abstract：:The recent deliberations by the U.S. Food and Drug Administration (FDA) regarding the relationship between antidepressants and suicidality in children have incited debates about the safety of these medications for the treatment of pediatric depression. In light of these events, this review discusses four issues pertai...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2005.10.010

    authors： Vasa RA,Carlino AR,Pine DS

    更新日期：2006-06-01 00:00:00

  • Specific IgA antibody increases in schizophrenia.

    abstract：:IgA antibody levels in serum were examined in two groups of schizophrenic patients. All were diagnosed according to DSM-III-R criteria. One group of 36 males and 12 females were compared to historical controls. The other group consisted of 13 males off drugs for at least 3 months; these were compared with age- and sex...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(94)00176-4

    authors： Reichelt KL,Landmark J

    更新日期：1995-03-15 00:00:00

  • Jumping the Gun: Mapping Neural Correlates of Waiting Impulsivity and Relevance Across Alcohol Misuse.

    abstract：BACKGROUND:Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS:We used a recently...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.06.009

    authors： Morris LS,Kundu P,Baek K,Irvine MA,Mechelmans DJ,Wood J,Harrison NA,Robbins TW,Bullmore ET,Voon V

    更新日期：2016-03-15 00:00:00

  • Low respiratory sinus arrhythmia and prolonged psychophysiological arousal in posttraumatic stress disorder: heart rate dynamics and individual differences in arousal regulation.

    abstract：BACKGROUND:There is extensive evidence that the parasympathetic branch of the autonomic nervous system can modulate psychophysiological arousal. To date, no studies have investigated associations between cardiac vagal tone and the time course of arousal during exposure to trauma-related stimuli in posttraumatic stress ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00677-2

    authors： Sack M,Hopper JW,Lamprecht F

    更新日期：2004-02-01 00:00:00

  • A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder.

    abstract：BACKGROUND:Accurate recognition of facial expressions is crucial for social functioning. In depressed individuals, implicit and explicit attentional biases away from happy and toward sad stimuli have been demonstrated. These may be associated with the negative cognitions in these individuals. METHODS:Using event-relat...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.10.028

    authors： Surguladze S,Brammer MJ,Keedwell P,Giampietro V,Young AW,Travis MJ,Williams SC,Phillips ML

    更新日期：2005-02-01 00:00:00

  • The agonist-stimulated accumulation of inositol phosphates is attenuated in neutrophils from male patients under chronic lithium therapy.

    abstract：:Neutrophils from 22 patients (11 men, 11 women) under chronic lithium therapy and from 22 age- and sex-matched healthy controls were assessed for the activity of the agonist-stimulated inositol-phospholipid second messenger-producing system. [3H]inositol-labeled cells were stimulated with the chemotactic peptide formy...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90305-6

    authors： Greil W,Steber R,van Calker D

    更新日期：1991-09-01 00:00:00

  • Developing novel treatments for mood disorders: accelerating discovery.

    abstract：:This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad stroke...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(02)01470-1

    authors： Tamminga CA,Nemeroff CB,Blakely RD,Brady L,Carter CS,Davis KL,Dingledine R,Gorman JM,Grigoriadis DE,Henderson DC,B Innis RB,Killen J,Laughren TP,McDonald WM,M Murphy GM Jr,Paul SM,Rudorfer MV,Sausville E,Schatzberg AF

    更新日期：2002-09-15 00:00:00

  • Glutamate-based antidepressants: preclinical psychopharmacology.

    abstract：:Over the past 20 years, converging lines of evidence have both linked glutamatergic dysfunction to the pathophysiology of depression and demonstrated that the glutamatergic synapse presents multiple targets for developing novel antidepressants. The robust antidepressant effects of the N-methyl-D-aspartate receptor ant...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2013.01.021

    authors： Pilc A,Wierońska JM,Skolnick P

    更新日期：2013-06-15 00:00:00

  • A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia.

    abstract：BACKGROUND:Synapsin III plays a role in neuronal plasticity and maps to chromosome 22q12-13, a region suggested to be linked to schizophrenia. To determine if synapsin III plays a role in this disease, we searched for polymorphisms in this gene in patients with schizophrenia and controls. METHODS:The synapsin III gene...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2003.07.002

    authors： Porton B,Ferreira A,DeLisi LE,Kao HT

    更新日期：2004-01-15 00:00:00

  • Smooth pursuit eye movements and attention in psychiatric patients.

    abstract：:The effects of two putative attention-engaging maneuvers on tracking performance were studied in three groups of subjects: inpatients (n = 19), outpatients (n = 19), and controls (n = 20). One method involved realerting subjects during tracking by repeating instructions to track carefully. The second method, a signal ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Pivik RT

    更新日期：1979-12-01 00:00:00

  • The TRH-stimulation test in DSM-III personality disorder.

    abstract：:The authors examined thyrotropin-releasing hormone (TRH) stimulation testing in the neuroendocrine evaluation of DSM-III major depressive disorder in 26 consecutive medication-free, medically healthy patients meeting a primary DSM-III diagnosis of axis II personality disorder. Thyroid-stimulating hormone (TSH) respons...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(93)90077-q

    authors： Kavoussi RJ,Coccaro EF,Klar H,Lesser J,Siever LJ

    更新日期：1993-08-15 00:00:00

  • Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program.

    abstract：:Our intent was to investigate systematically the overlap between conduct disorder (CD) and bipolar disorder (BPD). We hypothesized that neither CD nor manic symptoms were secondary to the other disorder and that children with the two disorders would have correlates of both. Results from a series of programmatic studie...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(03)00009-x

    authors： Biederman J,Mick E,Wozniak J,Monuteaux MC,Galdo M,Faraone SV

    更新日期：2003-06-01 00:00:00

  • Stimulated gene expression profiles as a blood marker of major depressive disorder.

    abstract：BACKGROUND:Major depressive disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. METHODS:We used a classifier approach on blood gene expression profiles of a unique set of unmedicated subjects (MDD patients and...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.03.017

    authors： Spijker S,Van Zanten JS,De Jong S,Penninx BW,van Dyck R,Zitman FG,Smit JH,Ylstra B,Smit AB,Hoogendijk WJ

    更新日期：2010-07-15 00:00:00

  • Nocturnal/daytime urine noradrenergic measures and sleep in combat-related PTSD.

    abstract：:Prominent heightened arousal symptoms and clinical/laboratory findings implicate the central noradrenergic system in posttraumatic stress disorder (PTSD). Heightened arousal frequently manifests in relation to sleep in PTSD. Central noradrenergic systems have a role in regulating arousal levels during sleep. We theref...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(94)00238-X

    authors： Mellman TA,Kumar A,Kulick-Bell R,Kumar M,Nolan B

    更新日期：1995-08-01 00:00:00

  • Auditory sensory processing in autism: a magnetoencephalographic study.

    abstract：BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00295-6

    authors： Tecchio F,Benassi F,Zappasodi F,Gialloreti LE,Palermo M,Seri S,Rossini PM

    更新日期：2003-09-15 00:00:00

  • Serotonin inhibition and sleep.

    abstract：:Methysergide a clinically used blocker of serotonin receptors, was given for 48 hr to 11 normal adults, at a dose of 8 mg per 24 hr. Total REM sleep time was decreased, although total sleep time was unchanged. Stage 4 decreased and stage 3 increased, while total slow wave sleep remained constant. There was a tendency ...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：

    authors： Mendelson WB,Reichman J,Othmer E

    更新日期：1975-08-01 00:00:00

  • The developmental psychopathology of social anxiety disorder.

    abstract：:The role of developmental theory and developmental psychopathology in understanding the development, maintenance, and course of social anxiety disorder (SAD) is explored in this article. Following a brief examination of the phenomenology of SAD in youth, we provide an overview of the tenets of developmental psychology...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(01)01305-1

    authors： Ollendick TH,Hirshfeld-Becker DR

    更新日期：2002-01-01 00:00:00

  • Skin conductance activity after intraventricular administration of 6-hydroxydopa in rats.

    abstract：:Absence of skin conductance response (SCR) and failure of its habituation are psychophysiological signs observed in most schizophrenics. In the present experiments, skin conductance activity was studied in rats before and after intraventricular administration of 6-hydroxydopa (6-OHdopa), a neurotoxin that selectively ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90222-8

    authors： Yamamoto K,Hoshino T,Takahashi Y,Kaneko H,Ozawa N

    更新日期：1991-02-15 00:00:00

  • Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions.

    abstract：BACKGROUND:The demands of the Wisconsin Card Sorting Test (WCST) change with experience. This report contains two studies designed to examine N-methyl-D-aspartate (NMDA) receptor contributions to the executive components of WCST performance. These aspects of WCST performance figure more prominently in the initial compl...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00097-9

    authors： Krystal JH,Bennett A,Abi-Saab D,Belger A,Karper LP,D'Souza DC,Lipschitz D,Abi-Dargham A,Charney DS

    更新日期：2000-01-15 00:00:00

  • "Normal" personality correlates of sensorimotor, cognitive, and visuospatial gating.

    abstract：:Specific psychiatric disorders are characterized by impaired selective inhibition or "gating" of responses to sensory or cognitive information. Less is known about gating differences among normal individuals. We tested carefully screened controls in measures of central inhibition: prepulse inhibition (PPI) of startle,...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(94)00138-S

    authors： Swerdlow NR,Filion D,Geyer MA,Braff DL

    更新日期：1995-03-01 00:00:00

  • An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism.

    abstract：BACKGROUND:Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.11.010

    authors： Meziane H,Schaller F,Bauer S,Villard C,Matarazzo V,Riet F,Guillon G,Lafitte D,Desarmenien MG,Tauber M,Muscatelli F

    更新日期：2015-07-15 00:00:00

  • Fluoxetine and neuroleptic malignant syndrome.

    abstract：:The authors present a case report of neuroleptic malignant syndrome (NMS) in a patient commencing treatment with fluoxetine alone who had previously been treated with several antipsychotic and antidepressant combinations. On reviewing the literature on the pathogenesis of NMS, the authors hypothesize a facilitative ro...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(90)90485-k

    authors： Halman M,Goldbloom DS

    更新日期：1990-09-15 00:00:00

  • Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence.

    abstract：BACKGROUND:Intimate partner violence (IPV) is one of the most common causes of posttraumatic stress disorder (PTSD) in women. Women with IPV-related PTSD often experience comorbid chronic pain and pain-related disability. Despite the high comorbidity between PTSD and chronic pain, recent evidence suggests that male vet...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.03.034

    authors： Strigo IA,Simmons AN,Matthews SC,Grimes EM,Allard CB,Reinhardt LE,Paulus MP,Stein MB

    更新日期：2010-09-01 00:00:00

  • Neurochemical changes in rat brain amines after short- and long-term inhibition of monoamine oxidase by a low dose of tranylcypromine.

    abstract：:The effects of short- and long-term administration of a low dose of tranylcypromine on brain and urine levels of several biogenic amines and on brain activity of monoamine oxidases (MAO) A and B were investigated. MAO-A and MAO-B were inhibited by greater than 85% on day 1, and this inhibition continued to increase ov...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(88)90033-9

    authors： Hampson DR,Baker GB,Coutts RT

    更新日期：1988-02-01 00:00:00