Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive disorders.

Abstract:

:The dexamethasone suppression test (DST) and sleep EEG were compared in three different descriptive diagnostic schemes in 70 adult patients with nonpsychotic, unipolar major depressive disorder according to Research Diagnostic Criteria. Endogenous (E)/nonendogenous (NE), primary/secondary, and Winokur's family history subtypes were evaluated. The E/NE subclassification was best supported by both biological measures. The DST provided a highly specific (95%), relatively accurate measure (confidence interval of 87%), although its sensitivity was rather low (41%) in this largely outpatient sample. A REM latency of 62 min or less provided a more sensitive (66%) but less specific (79%) indicator of E depression. Stage 4 time and age may add to the information provided by REM latency alone in identifying E patients.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Rush AJ,Giles DE,Roffwarg HP,Parker CR

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

327-41

issue

3

eissn

0006-3223

issn

1873-2402

journal_volume

17

pub_type

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