Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia.

abstract：:Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some conditions are defined by the presence of impairments in social interaction or maintaining interpersonal relationships;...

journal_title：Biological psychiatry

authors： King-Casas B,Chiu PH

更新日期：2012-07-15 00:00:00

abstract：BACKGROUND:Regional brain perfusion in patients during alcohol-withdrawal has been relatively less studied with brain SPECT technique. In this study, the hypothesis that possible regional cerebral blood flow (rCBF) alterations due to alcohol withdrawal might be transitory in a homogenous group of alcoholic patients in ...

journal_title：Biological psychiatry

authors： Tutus A,Kuğu N,Sofuoğlu S,Nardali M,Simşek A,Karaaslan F,Gönül AS

更新日期：1998-06-15 00:00:00

abstract：BACKGROUND:Variations in maternal care in the rat associate with robust differences in hippocampal development and synaptic plasticity in the offspring. Maternal care also influences pituitary-adrenal stress responses and corticosterone (CORT) regulation of hippocampal plasticity. N-methyl-D-aspartate receptors (NMDAR)...

journal_title：Biological psychiatry

authors： Bagot RC,Tse YC,Nguyen HB,Wong AS,Meaney MJ,Wong TP

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:Subjects at increased risk for psychosis experience continuous variation in the intensity of subtle psychotic experiences in response to minor stressors. It was investigated whether this psychotic reactivity in individuals at risk for psychosis is the exophenotypic expression of an underlying endophenotype c...

journal_title：Biological psychiatry

authors： Myin-Germeys I,Marcelis M,Krabbendam L,Delespaul P,van Os J

更新日期：2005-07-15 00:00:00

abstract：BACKGROUND:Marijuana use by teenagers often predates the use of harder drugs, but the neurobiological underpinnings of such vulnerability are unknown. Animal studies suggest enhanced heroin self-administration (SA) and dysregulation of the endogenous opioid system in the nucleus accumbens shell (NAcsh) of adults follow...

journal_title：Biological psychiatry

authors： Tomasiewicz HC,Jacobs MM,Wilkinson MB,Wilson SP,Nestler EJ,Hurd YL

更新日期：2012-11-15 00:00:00

abstract：:The current concept that blunted adrenocorticotropic hormone (ACTH) response to human corticotropin-releasing-hormone (h-CRH) in depression is primarily determined by elevated circulating plasma cortisol levels is still unproven. We tested this hypothesis by comparing ACTH release following intravenous administration ...

journal_title：Biological psychiatry

authors： von Bardeleben U,Stalla GK,Müller OA,Holsboer F

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:The neural projections from the infralimbic region of the prefrontal cortex to the amygdala are important for the maintenance of conditioned fear extinction. Neurons in this pathway exhibit a unique pattern of structural plasticity that is sex-dependent, but the relationship between the morphologic character...

journal_title：Biological psychiatry

authors： Gruene TM,Roberts E,Thomas V,Ronzio A,Shansky RM

更新日期：2015-08-01 00:00:00

abstract：:Seven women with histories of puerperal psychosis and four with histories of puerperal major depression were consecutively treated with high-dose oral estrogen immediately following delivery. None of the women had histories of nonpuerperal affective disorder, and all women were affectively well throughout the current ...

journal_title：Biological psychiatry

authors： Sichel DA,Cohen LS,Robertson LM,Ruttenberg A,Rosenbaum JF

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:Two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior were used to identify neurobiological correlates of trait anxiety. METHODS:We used Fos expression for mapping of neuronal activation patterns in response to mild anxiety-provoking challenges. RESULTS:In both l...

journal_title：Biological psychiatry

authors： Salomé N,Salchner P,Viltart O,Sequeira H,Wigger A,Landgraf R,Singewald N

更新日期：2004-04-01 00:00:00

abstract：:The effects of naltrexone on both mood and cognition were examined in overweight male subjects. Subjects were randomly prescribed, in a double-blind fashion, either placebo or naltrexone for 8 weeks. The results of the study showed that a chronic administration of a high dose of naltrexone (300 mg/day) does not signif...

journal_title：Biological psychiatry

authors： Hatsukami DK,Mitchell JE,Morley JE,Morgan SF,Levine AS

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Schizophrenic patients have high rates of cigarette smoking compared with the general population. We compared sustained-release (SR) bupropion with placebo for smoking cessation in patients with schizophrenic disorders. We also examined how antipsychotic class predicts smoking cessation outcomes with bupropi...

journal_title：Biological psychiatry

authors： George TP,Vessicchio JC,Termine A,Bregartner TA,Feingold A,Rounsaville BJ,Kosten TR

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:There is a paucity of neuroimaging data in pediatric-onset obsessive-compulsive disorder (OCD). This multimodal neuroimaging study aimed to identify structural gray (GM) and white matter (WM) microstructure changes in pediatric OCD. METHODS:We obtained structural and diffusion tensor magnetic resonance imag...

journal_title：Biological psychiatry

authors： Zarei M,Mataix-Cols D,Heyman I,Hough M,Doherty J,Burge L,Winmill L,Nijhawan S,Matthews PM,James A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Metyrapone blocks cortisol synthesis which results in removal of negative feedback, a stimulation of hypothalamic corticotropin releasing factor (CRF) and a reduction in delta sleep. We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with po...

journal_title：Biological psychiatry

authors： Otte C,Lenoci M,Metzler T,Yehuda R,Marmar CR,Neylan TC

更新日期：2007-04-15 00:00:00

abstract：:Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been reported in several studies. The G72/G30 locus may be one of several that account for the evidence of linkage that spans a broad region of chromosome 13q. However, the story of G72/G30 is complex. Our meta-analysis of published assoc...

journal_title：Biological psychiatry

authors： Detera-Wadleigh SD,McMahon FJ

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. METHODS:Associations were investigated between CAG repeat length and gender, age of illness onset, and psych...

journal_title：Biological psychiatry

authors： Cardno AG,Bowen T,Guy CA,Jones LA,McCarthy G,Williams NM,Murphy KC,Spurlock G,Gray M,Sanders RD,Craddock N,McGuffin P,Owen MJ,O'Donovan MC

更新日期：1999-06-15 00:00:00

abstract：:There is a strong association between depression and smoking. Because monoamine oxidase (MAO) inhibition leads to antidepressant effect and in vitro studies have shown that cigarette smoke inhibits MAO activity, it is conceivable that smoking may have an antidepressant effect, if smokers have reduced MAO activity. The...

journal_title：Biological psychiatry

authors： Berlin I,Said S,Spreux-Varoquaux O,Olivares R,Launay JM,Puech AJ

更新日期：1995-12-01 00:00:00

abstract：:The smooth pursuit responses to 5 degrees and 20 degrees/sec constant-velocity stimuli were recorded from 23 patients with schizophrenia, 16 affective disorder patients, and 21 normals using low-noise infrared oculography. Pursuit gain, catch-up saccade (CUS) rate and amplitude, and their interrelationships were exami...

journal_title：Biological psychiatry

authors： Abel LA,Friedman L,Jesberger J,Malki A,Meltzer HY

更新日期：1991-06-01 00:00:00

abstract：:The locus coeruleus (LC) is the major noradrenergic nucleus in the brain and innervates large segments of the neuraxis. LC neurons are thought to regulate states of attention and vigilance as well as activity of the sympathetic nervous system. These neurons also have been implicated in the actions of stress, antidepre...

journal_title：Biological psychiatry

authors： Nestler EJ,Alreja M,Aghajanian GK

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Chronic pain is clinically associated with the development of affective disorders. However, studies in animal models of neuropathic pain are contradictory and the relationship with mood disorders remains unclear. In this study, we aimed to characterize the affective consequences of neuropathic pain over time...

journal_title：Biological psychiatry

authors： Yalcin I,Bohren Y,Waltisperger E,Sage-Ciocca D,Yin JC,Freund-Mercier MJ,Barrot M

更新日期：2011-11-15 00:00:00

abstract：:Using computed tomography, lateral ventricular size was determined in 45 schizophrenic and 22 affective disorder patients, and was found in both patient groups to be greater than that of 62 similarly aged headache controls. While drug-free, the 15 schizophrenics with ventricles 1 standard deviation greater than the ag...

journal_title：Biological psychiatry

authors： Luchins DJ,Lewine RR,Meltzer HY

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The observation that some patients with schizophrenia display subtly anomalous craniofacial features dates back to the early 1900s and has recently been hypothesized to reflect disrupted prenatal development also involving the brain. Most studies to date have used observer ratings rather than physical measur...

journal_title：Biological psychiatry

authors： Donovan-Lepore AM,Jaeger J,Czobor P,Abdelmessih S,Berns SM

更新日期：2006-02-15 00:00:00

abstract：:We compared the EEG-monitored sleep of 8 women with anorexia nervosa and 16 normal weight women with bulimia to that of 14 normal women. The patients with anorexia nervosa spent less time asleep and spent less of their sleep time in Stage 1. The sleep of the normal weight patients with bulimia was remarkably similar t...

journal_title：Biological psychiatry

authors： Walsh BT,Goetz R,Roose SP,Fingeroth S,Glassman AH

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Deletions encompassing a four-gene region on chromosome 15 (BP1-BP2 at 15q11.2), seen at a population frequency of 1 in 500, are associated with increased risk for schizophrenia, epilepsy, and other common neurodevelopmental disorders. However, little is known in terms of how these common deletions impact co...

journal_title：Biological psychiatry

authors： Woo YJ,Kanellopoulos AK,Hemati P,Kirschen J,Nebel RA,Wang T,Bagni C,Abrahams BS

更新日期：2019-08-15 00:00:00

abstract：:Posttraumatic stress disorder (PTSD) is a stress-related psychiatric disorder that is thought to emerge from complex interactions among traumatic events and multiple genetic factors. Epigenetic regulation lies at the heart of these interactions and mediates the lasting effects of the environment on gene regulation. An...

journal_title：Biological psychiatry

authors： Zannas AS,Provençal N,Binder EB

更新日期：2015-09-01 00:00:00

abstract：:We examined the circadian rhythm of core body temperature (CBT) in 22 school refusal patients, ages between 12 and 18 years, who did not have any physical or psychiatric disorders, but had indefinite complaints, and were suspected to have a circadian rhythm disturbance. To obtain normal data for analysis, CBT in 9 hea...

journal_title：Biological psychiatry

authors： Tomoda A,Miike T,Yonamine K,Adachi K,Shiraishi S

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Some small controlled studies have found that dawn simulation is effective in treating seasonal affective disorder (SAD). With a larger sample size and a longer duration of treatment, we compared dawn simulation with bright light therapy and a placebo condition in patients with SAD. METHOD:Medication-free p...

journal_title：Biological psychiatry

authors： Avery DH,Eder DN,Bolte MA,Hellekson CJ,Dunner DL,Vitiello MV,Prinz PN

更新日期：2001-08-01 00:00:00

abstract：:Certain investigators have asserted that the illness of anorexia nervosa is a form of hypothalamic disturbance. The relationship between 24-hr urine 3-methoxy-4-hydroxyphenylglycol (MHPG) and dexamethasone suppression tests was examined in 13 female patients with AN diagnosed by RDC. Patients showed a consistent assoc...

journal_title：Biological psychiatry

authors： Gwirtsman HE,Gerner RH

更新日期：1981-10-01 00:00:00

abstract：:The diagnosis of schizophrenia rests on clinical criteria that cannot be assessed in animal models. Together with absence of a clear underlying pathology and understanding of what causes schizophrenia, this has hindered development of informative animal models. However, recent large-scale genomic studies have identifi...

journal_title：Biological psychiatry

authors： Forsingdal A,Jørgensen TN,Olsen L,Werge T,Didriksen M,Nielsen J

更新日期：2019-01-01 00:00:00

abstract：:A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity ca...

journal_title：Biological psychiatry

authors： el-Mallakh RS,Wyatt RJ

更新日期：1995-02-15 00:00:00

abstract：:Advances in the understanding of the neurobiology of fear extinction have resulted in the development of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, as an augmentation strategy for exposure treatment. We review a decade of research that has focused on the efficacy of DCS for augmenting t...

journal_title：Biological psychiatry

authors： Otto MW,Kredlow MA,Smits JAJ,Hofmann SG,Tolin DF,de Kleine RA,van Minnen A,Evins AE,Pollack MH

更新日期：2016-08-15 00:00:00