Abstract：
BACKGROUND:Long CAG repeats in the hKCa3 potassium channel gene have been associated with schizophrenia. We sought evidence for associations between this polymorphism and aspects of the schizophrenia phenotype. METHODS:Associations were investigated between CAG repeat length and gender, age of illness onset, and psychotic symptom dimensions in 203 unrelated individuals with DSM-IIIR schizophrenia. RESULTS:No association was found between CAG repeat length and gender or age of onset. Long CAG repeats were associated with higher negative symptom dimension scores. CONCLUSIONS:This study provides preliminary evidence that genetic liability to negative symptoms in schizophrenia may be partly mediated through the hKCa3 gene.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Cardno AG,Bowen T,Guy CA,Jones LA,McCarthy G,Williams NM,Murphy KC,Spurlock G,Gray M,Sanders RD,Craddock N,McGuffin P,Owen MJ,O'Donovan MCdoi
10.1016/s0006-3223(99)00033-5subject
Has Abstractpub_date
1999-06-15 00:00:00pages
1592-6issue
12eissn
0006-3223issn
1873-2402pii
S0006322399000335journal_volume
45pub_type
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journal_title：Biological psychiatry
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