Monoamine metabolism during chronic benzodiazepine treatment and withdrawal.

abstract：BACKGROUND:The interactions among experience, emotion, and memory are considered to be instrumental in the ontogeny and maintenance of acquired emotional and behavioral disorders (e.g., phobias). Here we address the question whether an anxiety-like state can associate with taste to produce conditioned taste aversion (C...

journal_title：Biological psychiatry

authors： Guitton MJ,Dudai Y

更新日期：2004-12-01 00:00:00

abstract：:The syndrome of chronic fatigue, feverishness, diffuse pains, and other constitutional complaints, often precipitated by an acute infectious illness and aggravated by physical and emotional stressors, has a lengthy history in the medical literature. The Centers for Disease Control (CDC) recently formulated a case defi...

journal_title：Biological psychiatry

authors： Demitrack MA,Gold PW,Dale JK,Krahn DD,Kling MA,Straus SE

更新日期：1992-12-15 00:00:00

abstract：BACKGROUND:Binge eating is associated with obesity and has been conceptualized as "food addiction." However, this view has received only inconsistent support in humans, and limited evidence relates key neurocircuitry to the disorder. Moreover, relatively few studies have used pharmacologic functional magnetic resonance...

journal_title：Biological psychiatry

authors： Cambridge VC,Ziauddeen H,Nathan PJ,Subramaniam N,Dodds C,Chamberlain SR,Koch A,Maltby K,Skeggs AL,Napolitano A,Farooqi IS,Bullmore ET,Fletcher PC

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop th...

journal_title：Biological psychiatry

authors： Bronson SL,Chan JC,Bale TL

更新日期：2017-07-15 00:00:00

abstract：:Several studies have reported prolonged neural transmission times on auditory brainstem responses (ABRs) measured in autistic children, a finding which implicates CNS dysfunction at the level of the brainstem in autistic conditions. This study measured ABRs in 25 children and adults with pervasive developmental disord...

journal_title：Biological psychiatry

authors： Rumsey JM,Grimes AM,Pikus AM,Duara R,Ismond DR

更新日期：1984-10-01 00:00:00

abstract：:Anxious patients, and more specifically, patients experiencing panic attacks, are thought to have a significant biological component to their illness. This study looks at two promising biological markers associated with this patient population-mitral valve prolapse and lactate-induced panic. We present our findings, w...

journal_title：Biological psychiatry

authors： Dager SR,Cowley DS,Dunner DL

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Conflicting findings have emerged from studies examining the impact of depression on death and readmission following a coronary event, possibly reflecting differences in the measurement of "depression" and the onset of depression in relation to the coronary event. The aim of this study was to examine the rel...

journal_title：Biological psychiatry

authors： Parker GB,Hilton TM,Walsh WF,Owen CA,Heruc GA,Olley A,Brotchie H,Hadzi-Pavlovic D

更新日期：2008-10-15 00:00:00

abstract：BACKGROUND:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and depressive-like behaviors. Concomitantly, microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that micro...

journal_title：Biological psychiatry

authors： Wohleb ES,Terwilliger R,Duman CH,Duman RS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Gray and white matter volume deficits have been reported in many structural magnetic resonance imaging (MRI) studies of children with attention-deficit/hyperactivity disorder (ADHD); however, there is a paucity of structural MRI studies of adults with ADHD. This study used voxel based morphometry and applied...

journal_title：Biological psychiatry

authors： Seidman LJ,Biederman J,Liang L,Valera EM,Monuteaux MC,Brown A,Kaiser J,Spencer T,Faraone SV,Makris N

更新日期：2011-05-01 00:00:00

abstract：:Determinations of albumin and immunoglobulin G (IgG) were performed in paired cerebrospinal fluid (CSF) and serum samples from 24 subjects with schizophrenia. These determinations allowed calculation of two indices, one that is an indicator of integrity of the blood-brain barrier and the other a measure of selective I...

journal_title：Biological psychiatry

authors： Kirch DG,Kaufmann CA,Papadopoulos NM,Martin B,Weinberger DR

更新日期：1985-10-01 00:00:00

abstract：:The aim of the present study was to evaluate the pattern of basal cortisol release in PTSD and major depression using a chronobiological analysis. Plasma for cortisol determination was obtained from 15 combat veterans with PTSD, 14 subjects with major depression, and 15 normal men every 30 min during a 24-hour period ...

journal_title：Biological psychiatry

authors： Yehuda R,Teicher MH,Trestman RL,Levengood RA,Siever LJ

更新日期：1996-07-15 00:00:00

abstract：:Extracellular serotonin in striatum was studied in untreated streptozotocin-induced diabetic rats and in untreated nondiabetic rats that served as age-, food-, and sex-matched controls. Extracellular serotonin was studied under anesthesia in vivo and dynamically with voltammetry. The results showed that an early and s...

journal_title：Biological psychiatry

authors： Broderick PA,Jacoby JH

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Language delay is a hallmark feature of autism spectrum disorders (ASD). The identification of word boundaries in continuous speech is a critical first step in language acquisition that can be accomplished via statistical learning and reliance on speech cues. Importantly, early word segmentation skills have ...

journal_title：Biological psychiatry

authors： Scott-Van Zeeland AA,McNealy K,Wang AT,Sigman M,Bookheimer SY,Dapretto M

更新日期：2010-08-15 00:00:00

abstract：BACKGROUND:The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptic drugs is a major challenge. Clozapine has been one treatment option; however, it is not universally effective and is limited in its use by safety concerns. With the introduction of newer agents, their performance re...

journal_title：Biological psychiatry

authors： Tollefson GD,Birkett MA,Kiesler GM,Wood AJ,Lilly Resistant Schizophrenia Study Group.

更新日期：2001-01-01 00:00:00

abstract：:Cannabis use has been reported to increase the risk of developing schizophrenia and to worsen symptoms of the illness. Both of these outcomes might be attributable to the disruption by cannabis of the endogenous cannabinoid system's spatiotemporal regulation of the inhibitory circuitry in the prefrontal cortex that is...

journal_title：Biological psychiatry

authors： Volk DW,Lewis DA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Recent evidence from clinical studies and animal models of traumatic brain injury (TBI) suggest that neuronal and glial loss might progress after the initial insult in selectively vulnerable regions of the brain such as the hippocampus. There is also evidence that hippocampal dysfunction plays a role in the ...

journal_title：Biological psychiatry

authors： Jorge RE,Acion L,Starkstein SE,Magnotta V

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:Interruptions in SSRI treatment have been associated with adverse effects that can resemble depressive illness. We hypothesized that brain regions implicated in depression, with extensive serotonergic innervation, would exhibit changes in activity associated with emergence of symptoms following drug disconti...

journal_title：Biological psychiatry

authors： Henry ME,Kaufman MJ,Hennen J,Michelson D,Schmidt ME,Stoddard E,Vukovic AJ,Barreira PJ,Cohen BM,Renshaw PF

更新日期：2003-01-01 00:00:00

abstract：:The APOE genotypes of 45 elderly inpatients with major depression were determined to investigate the relationship of this disorder to irreversible dementia in late life. We specifically tested the hypothesis that the frequency of the APOE epsilon 4 allele is elevated in depressed elders with cognitive impairment or ps...

journal_title：Biological psychiatry

authors： Zubenko GS,Henderson R,Stiffler JS,Stabler S,Rosen J,Kaplan BB

更新日期：1996-11-15 00:00:00

abstract：:Cell lines of continuously dividing human olfactory neuroblasts can be propagated using olfactory epithelium obtained from human donors at biopsy or autopsy. The expression of neuronal proteins in these cells, such as neurofilament protein and tau protein, can be increased using a combination of factors including nerv...

journal_title：Biological psychiatry

authors： Wolozin B,Lesch P,Lebovics R,Sunderland T

更新日期：1993-12-15 00:00:00

abstract：:Buprenorphine is undergoing clinical trials for the treatment of opiate addiction. Although the abuse liability of sublingual buprenorphine is low, reports of intravenous abuse have appeared. This study describes the physiologic and subjective effects of intravenously administered buprenorphine and naloxone given alon...

journal_title：Biological psychiatry

authors： Mendelson J,Jones RT,Welm S,Brown J,Batki SL

更新日期：1997-06-01 00:00:00

abstract：:A patient with tardive neuroleptic-induced akathisia was investigated with multiple pharmacological challenges. It was noted that the patient responded positively to benztropine, bromocriptine, and propranolol, and negatively to physostigmine, and showed little or no response to discontinuation of neuroleptics and cha...

journal_title：Biological psychiatry

authors： Sachdev P,Chee KY

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...

journal_title：Biological psychiatry

authors： Lake EMR,Finn ES,Noble SM,Vanderwal T,Shen X,Rosenberg MD,Spann MN,Chun MM,Scheinost D,Constable RT

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:Elevated endogenous levels of corticosteroids cause neural dysfunction and loss, especially within the hippocampus, as well as cognitive impairment in hippocampus-mediated tasks. Because Cushing's syndrome patients suffer from hypercortisolism, they represent a unique opportunity to study the impact of eleva...

journal_title：Biological psychiatry

authors： Grillon C,Smith K,Haynos A,Nieman LK

更新日期：2004-12-01 00:00:00

abstract：:The involvement of the dopamine (DA) innervation of the medial prefrontal cortex (PFC) in attention was studied in a latent inhibition (LI) paradigm in rats. LI becomes evident by a retardation of conditioning to a stimulus after nonreinforced preexposure to that stimulus. LI is thought to reflect an animal's ability ...

journal_title：Biological psychiatry

authors： Broersen LM,Heinsbroek RP,de Bruin JP,Olivier B

更新日期：1996-12-01 00:00:00

abstract：:Animal models of social isolation have been suggested to be relevant to several neuropsychiatric disorders; however, social isolation is usually not purely an alteration of social environment, as it often involves such factors as decreased complexity of the environment, loss of tactile stimulation, and increased metab...

journal_title：Biological psychiatry

authors： Kim JW,Kirkpatrick B

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment. METHODS:Twenty-six elderly women who gave informed consent were divided into two groups, with or w...

journal_title：Biological psychiatry

authors： Andia I,Zumarraga M,Zabalo MJ,Bulbena A,Davila R

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPα, in the control of radial neuronal migration, cortical cytoarchitecture, and oligod...

journal_title：Biological psychiatry

authors： Takahashi N,Nielsen KS,Aleksic B,Petersen S,Ikeda M,Kushima I,Vacaresse N,Ujike H,Iwata N,Dubreuil V,Mirza N,Sakurai T,Ozaki N,Buxbaum JD,Sap J

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Chronic treatment of rats with certain selective serotonin or norepinephrine reuptake inhibitors produces significant decreases, respectively, in serotonin and norepinephrine transporter binding sites in brain. Duloxetine may be a dual serotonin/norepinephrine reuptake inhibitor, as it is only a slightly mor...

journal_title：Biological psychiatry

authors： Gould GG,Javors MA,Frazer A

更新日期：2007-01-15 00:00:00

abstract：:The present study was undertaken to investigate if acute anxiety can affect plasma concentrations of homovanillic acid (pHVA). Since elevated pHVA levels have been associated with severity of schizophrenic symptoms, the results of this study will help determine if the pHVA elevations are directly related to psychosis ...

journal_title：Biological psychiatry

authors： Zemishlany Z,Davidson M

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. METHODS:Twenty elderly patients meeting DSM-IV criteria for m...

journal_title：Biological psychiatry

authors： Lai T,Payne ME,Byrum CE,Steffens DC,Krishnan KR

更新日期：2000-11-15 00:00:00