Abstract：
BACKGROUND:Elevated endogenous levels of corticosteroids cause neural dysfunction and loss, especially within the hippocampus, as well as cognitive impairment in hippocampus-mediated tasks. Because Cushing's syndrome patients suffer from hypercortisolism, they represent a unique opportunity to study the impact of elevated glucocorticoids on cognitive functions. The aim of this study was to examine the performance of Cushing's syndrome patients on trace eyeblink conditioning, a cross-species, hippocampal-mediated test of learning and memory. METHODS:Eleven Cushing's syndrome patients and 11 healthy control subjects participated in an eyeblink trace conditioning test (1000-msec trace) and a task of declarative memory for words. Salivary cortisol was collected in both the patients and the control subjects, and urinary free cortisol was collected in the patients only. RESULTS:The patients exhibited fewer conditional responses and remembered fewer words, compared with the control subjects. Cortisol levels correlated with immediate and delayed declarative memory only. Conditional response correlated with delayed recall after controlling for the magnitude of unconditional response. CONCLUSIONS:The integrity of the hippocampus seems to be compromised in Cushing's syndrome patients. Trace eyeblink conditioning might be useful both as a clinical tool to examine changes in hippocampus function in Cushing's disease patients and as a translational tool of research on the impact of chronic exposure of glucocorticoids.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Grillon C,Smith K,Haynos A,Nieman LKdoi
10.1016/j.biopsych.2004.09.003subject
Has Abstractpub_date
2004-12-01 00:00:00pages
837-43issue
11eissn
0006-3223issn
1873-2402pii
S0006-3223(04)00942-4journal_volume
56pub_type
杂志文章abstract：:This study evaluated electrophysiological (EEG, ERGs), and cognitive (neuropsychological testing) responses in patients with late luteal phase dysphoric disorder (LLPDD, DSM-III-R) and controls over the menstrual cycle. In both groups, the frequency and stability of electroencephalogram (EEG) alpha activity significan...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/0006-3223(95)00183-2
更新日期：1996-04-15 00:00:00
abstract：BACKGROUND:Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment. METHODS:Twenty-six elderly women who gave informed consent were divided into two groups, with or w...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2005.01.030
更新日期：2005-05-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.04.014
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pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-10-01 00:00:00
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更新日期：2016-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2001-03-15 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2013.10.027
更新日期：2014-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2000-02-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2007-08-15 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-11-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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更新日期：1982-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2020-04-15 00:00:00
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