Abstract：
BACKGROUND:Evidence suggests that structural brain changes occur over time in bipolar disorder but few studies have examined this longitudinally. Additional work implicates brain-derived neurotrophic factor (BDNF) valine (val)(66)methionine (met) variant in these changes. The present study examined longitudinal trends in prefrontal gyrification index (GI) in bipolar disorder and the effect of BDNF genotype. METHODS:Eighteen patients with bipolar I disorder and 18 control subjects underwent magnetic resonance imaging at study entry and after 4 years. Prefrontal GI was computed as the ratio of folded inner contour to exposed outer contour. RESULTS:Ventral and dorsal GI decreased significantly with time in both cohorts; the rate did not differ for bipolar patients. Within the bipolar cohort, individuals with one or more BDNF met alleles showed greater losses in GI, an effect that correlated with gray matter loss in the left hemisphere. CONCLUSIONS:Gyrification index may be sensitive to atrophy, as well as being a neurodevelopmental measure. While the loss of prefrontal gyrification over time is not accelerated in bipolar disorder, a greater rate of loss is associated with the possession of one or more BDNF met alleles.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Mirakhur A,Moorhead TW,Stanfield AC,McKirdy J,Sussmann JE,Hall J,Lawrie SM,Johnstone EC,McIntosh AMdoi
10.1016/j.biopsych.2008.12.006subject
Has Abstractpub_date
2009-08-01 00:00:00pages
293-7issue
3eissn
0006-3223issn
1873-2402pii
S0006-3223(08)01568-0journal_volume
66pub_type
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