Abstract：
BACKGROUND:Cannabis remains the most widely used illicit substance by adolescents and is typically consumed by this population in the context of ongoing tobacco use. Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects of these drugs on brain function and cognition during adolescent development. METHODS:Verbal learning and memory were assessed in 20 adolescent users of tobacco and cannabis and 25 adolescent tobacco users with minimal history of cannabis use. Functional magnetic resonance imaging was used to examine brain function and functional connectivity while a subset of these subjects performed a verbal working memory task. RESULTS:Delayed recall of verbal stimuli deteriorated during nicotine withdrawal among cannabis users but not among comparison subjects. During high verbal working memory load, nicotine withdrawal selectively increased task-related activation of posterior cortical regions and was associated with disruption of frontoparietal connectivity in adolescent cannabis users relative to comparison subjects. CONCLUSIONS:These observations suggest that cannabis use during adolescent development may disrupt neurocircuitry supporting verbal memory formation and that deficits associated with disruption of these neurocircuits are unmasked during nicotine withdrawal.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Jacobsen LK,Pugh KR,Constable RT,Westerveld M,Mencl WEdoi
10.1016/j.biopsych.2006.02.014subject
Has Abstractpub_date
2007-01-01 00:00:00pages
31-40issue
1eissn
0006-3223issn
1873-2402pii
S0006-3223(06)00232-0journal_volume
61pub_type
杂志文章abstract：:A high incidence of behavioral and learning difficulties has been found in juvenile seizure-prone baboons presented with a graded series of operant behavioral task challenges. The animals fell into two distinct groups based upon the rate at which their operant performance was able to develop, the amount of day-to-day ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90040-7
更新日期：1992-08-15 00:00:00
abstract：:Potential recovery of electrophysiological and neuropsychological functions was investigated in alcoholics completing treatment and controls. Event-related potentials (ERPs) and neuropsychological tests were administered initially and repeated 14 months later. Alcoholics were classified as resumers or abstainers based...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)90639-4
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND:Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS:This 10-week, acute, randomized, controlled, masked trial compared adjunc...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.biopsych.2005.05.025
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Conflicting findings have emerged from studies examining the impact of depression on death and readmission following a coronary event, possibly reflecting differences in the measurement of "depression" and the onset of depression in relation to the coronary event. The aim of this study was to examine the rel...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.05.021
更新日期：2008-10-15 00:00:00
abstract：BACKGROUND:Reinforcement of behavioral responses involves a complex cerebral circuit engaging specific neuronal networks that are modulated by cortical oversight systems affiliated with emotion, memory, judgment, and decision making (collectively referred to in this study as the "extended reward and oversight system" o...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.01.018
更新日期：2008-08-01 00:00:00
abstract：:Acetylcholinesterase (AChE) from erythrocytes was solubilized by Triton X-100. Size and charge heterogeneity of AChE was investigated by polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) in polyacrylamide gels in the presence of 0.5% (v/v) Triton X-100. There were no interindividual differences ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(87)90052-7
更新日期：1987-09-01 00:00:00
abstract：BACKGROUND:Few studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturban...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.12.013
更新日期：2014-10-15 00:00:00
abstract：:Research published in the past decade that used quantitative indices to evaluate the waking EEG characteristics of depressed patients is reviewed. Methodological problems that make results of different research laboratories difficult to compare include diagnostic heterogeneity of depressed groups, lack of inclusion of...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0006-3223(90)90591-o
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:A central cognitive function of sleep is to consolidate newly acquired memories for long-term storage. Here, we investigated whether the overnight consolidation of declarative memory in patients with chronic sleep disturbances is impaired, owing to less slow wave sleep (SWS) and an increased cortisol release...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.03.051
更新日期：2006-12-15 00:00:00
abstract：:The effect of Vincamine and Piracetam, two geriatric drugs, on sleep behavior of the laboratory cat was studied. The animals were chronically prepared for recording of the EEG of the cerebral cortex, the lateral geniculate body, and the hippocampus, and for recording of eye movements, the muscular tonus and respiratio...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:Cognitive behavioral therapy (CBT) has efficacy for binge eating disorder (BED) but not obesity. No controlled studies have tested whether adding obesity medication to CBT facilitates weight loss. We performed a randomized, placebo-controlled study of orlistat administered with guided self-help CBT (CBTgsh)....
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.biopsych.2005.03.001
更新日期：2005-05-15 00:00:00
abstract：:The volume of the entorhinal region is significantly reduced in postmortem brains of schizophrenics compared with controls (p less than 0.017). In addition, a significant reduction of neurons (p less than 0.017), but no significant increase in absolute glial cell numbers, is found. These results are consistent with th...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90162-x
更新日期：1988-09-01 00:00:00
abstract：:We compared the EEG-monitored sleep of 8 women with anorexia nervosa and 16 normal weight women with bulimia to that of 14 normal women. The patients with anorexia nervosa spent less time asleep and spent less of their sleep time in Stage 1. The sleep of the normal weight patients with bulimia was remarkably similar t...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(85)90191-x
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND:The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2003.11.002
更新日期：2004-01-15 00:00:00
abstract：:The current concept that blunted adrenocorticotropic hormone (ACTH) response to human corticotropin-releasing-hormone (h-CRH) in depression is primarily determined by elevated circulating plasma cortisol levels is still unproven. We tested this hypothesis by comparing ACTH release following intravenous administration ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90254-5
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous administration of the N-methyl-D-aspartate antagonist ketamine produced rapid antidepressant effects in patients with treatment...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2011.12.010
更新日期：2012-06-01 00:00:00
abstract：:Taken as a whole the data presented provide support for Klein's conceptualization of etiologically distinct subtypes of depression. A basic limbic system derangement in endogenous depression is suggested by the higher incidence of DST nonsuppression. Beck's theory that all depressions result from a primary cognitive d...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：BACKGROUND:Accumulating evidence suggests the involvement of inflammatory processes and cytokines in particular in the pathophysiology of major depression (MDD) and resistance to antidepressant treatment. Furthermore, amygdala and anterior cingulate cortex (ACC) responsiveness to emotional stimuli has been suggested as...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.11.004
更新日期：2010-03-15 00:00:00
abstract：BACKGROUND:The incubation of cue-induced drug craving in rodents provides a model of persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal, incubated cocaine craving depends on strengthening of nucleus accumbens (NAc) core synapses through incorporation of Ca2+-permeable alpha-ami...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.04.003
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Growing evidence supports a pivotal role for the amygdala in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ). However, the occurrence of morphologic changes in the amygdala is currently controversial. METHODS:Total number and numeric density of neurons, neuronal somata size, and volume of t...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.04.023
更新日期：2007-10-15 00:00:00
abstract：:Animal models of mental illness provide a foundation for evaluating hypotheses for the mechanistic causes of mental illness. Neurophysiological investigations of neural network activity in rodent models of mental dysfunction are reviewed from the conceptual framework of the discoordination hypothesis, which asserts th...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.03.013
更新日期：2015-06-15 00:00:00
abstract：BACKGROUND:Patients with bipolar disorder have been reported to have abnormal cortical function during mania. In this study, we sought to investigate neural activity in the frontal lobe during mania, using functional magnetic resonance imaging (fMRI). Specifically, we sought to evaluate activation in the lateral orbito...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2005.09.012
更新日期：2005-11-15 00:00:00
abstract：BACKGROUND:Few studies have examined the involvement of the central dopaminergic system in the pathophysiology of mood disorders. The study of prolactin (PRL) secretion may be an informative indirect method for the assessment of the dopaminergic system in children with major depressive disorder (MDD). METHODS:Plasma P...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00005-0
更新日期：1999-08-15 00:00:00
abstract：BACKGROUND:The medial prefrontal cortex (mPFC) subserves complex cognition and is impaired by stress. Corticotropin-releasing factor (CRF), through CRF receptor 1 (CRFR1), constitutes a key element of the stress response. However, its contribution to the effects of stress in the mPFC remains unclear. METHODS:Mice were...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.03.2106
更新日期：2016-11-15 00:00:00
abstract：:Mutations in mitochondrial DNA (mtDNA) are implicated in the pathophysiology of affective disorders. To determine whether the 4977-base-pair deletion in mtDNA is more frequent in affective disorders, we quantitated the concentration of this deletion in leukocyte mtDNA in 34 probands with affective disorders (20 bipola...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/S0006-3223(96)00377-0
更新日期：1997-09-01 00:00:00
abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90061-4
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment. METHODS:In this multicenter, double-blind study, outpatients with recurrent unipolar major depression were randomly assigned to receive venlafaxine ER (75-3...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.biopsych.2007.04.040
更新日期：2007-12-15 00:00:00
abstract：:Psychiatric disorders show high rates of comorbidity and nonspecificity of presenting clinical symptoms, while demonstrating substantial heterogeneity within diagnostic categories. Notably, many of these psychiatric disorders first manifest in youth. We review progress and next steps in efforts to parse heterogeneity ...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2019.12.015
更新日期：2020-07-01 00:00:00
abstract：:Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer's disease, there is a need for new and more effective treatments. Galantamine is a novel treatment for Alzheimer's disease that inhibits acetylcholinesterase and modulates nicotinic receptors. In randomized, double-blind, placebo-controlled st...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(00)01101-x
更新日期：2001-02-01 00:00:00
