当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease.

Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease.

Abstract：

:Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer's disease, there is a need for new and more effective treatments. Galantamine is a novel treatment for Alzheimer's disease that inhibits acetylcholinesterase and modulates nicotinic receptors. In randomized, double-blind, placebo-controlled studies of up to 6 months duration, galantamine significantly improved cognitive function. Galantamine also had beneficial effects on instrumental and basic activities of daily living, and postponed the progression of behavioral symptoms. Patients who completed one of the 6-month, placebo-controlled studies were eligible to enter a 6-month, open-extension study of the 24-mg/day dose of galantamine. At the end of 12 months, cognitive function and activities of daily living were preserved in those patients who had been treated throughout the study with galantamine 24 mg/day. At 12 months, this group of patients had significantly better cognitive functions than patients who had been treated with a placebo for 6 months before receiving galantamine. These studies indicate that galantamine postpones the progression of symptoms in Alzheimer's disease. Since galantamine shows the greatest benefits when treatment is started early, its long-term benefits may result from an effect on the underlying disease process; such an effect might be mediated by galantamine's concomitant action on nicotinic receptors.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Coyle J,Kershaw P

doi

10.1016/s0006-3223(00)01101-x

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

289-99

issue

3

eissn

0006-3223

issn

1873-2402

pii

S000632230001101X

journal_volume

49

pub_type

杂志文章,评审

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Learning deficiencies in Borna disease virus-infected but clinically healthy rats.

    abstract：:Borna disease (BD) virus, a still unclassified neurotropic agent, causes either fatal encephalomyelitis or persistent asymptomatic infection in a variety of animal species. We monitored the neuronal functions of intracerebrally infected but healthy rats with three types of learning experiments. Spatial discrimination ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(89)90122-4

    authors： Dittrich W,Bode L,Ludwig H,Kao M,Schneider K

    更新日期：1989-12-01 00:00:00

  • A Common Polymorphism in a Williams Syndrome Gene Predicts Amygdala Reactivity and Extraversion in Healthy Adults.

    abstract：BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced so...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.12.007

    authors： Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri AR

    更新日期：2017-02-01 00:00:00

  • Biological stress responses in high and low trait anxious students.

    abstract：:In an investigation of biological indicators of stress in normal humans, undergraduate psychology students were differentiated on trait anxiety and assessed under baseline, preexam (stress), and postexam conditions. Assessment at each condition involved drawing 20 ml of blood, followed by self-reporting for selected q...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90209-4

    authors： Davis DD,Dunlop SR,Shea P,Brittain H,Hendrie HC

    更新日期：1985-08-01 00:00:00

  • The impact of alcoholism on sleep evoked Delta frequency responses.

    abstract：BACKGROUND:K-complexes (KCs) are evoked delta frequency electroencephalogram (EEG) responses during sleep that occur when large numbers of healthy cortical cells burst fire in a synchronized manner. The KC amplitude and incidence are sensitive measures of normal healthy brain aging. Given the known neurodegenerative co...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.10.010

    authors： Colrain IM,Crowley KE,Nicholas CL,Padilla M,Baker FC

    更新日期：2009-07-15 00:00:00

  • Brainstem correlates of defensive states in humans.

    abstract：BACKGROUND:Brainstem auditory evoked potentials (BAEP) reflect the activation of brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These electrophysiological correlates of neural processing are highly automatic and not influenced by cognitive factors or task demands; however, data f...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.09.009

    authors： Baas JM,Milstein J,Donlevy M,Grillon C

    更新日期：2006-04-01 00:00:00

  • A Stress-Induced Shift From Trace to Delay Conditioning Depends on the Mineralocorticoid Receptor.

    abstract：BACKGROUND:Fear learning in stressful situations is highly adaptive for survival by steering behavior in subsequent situations, but fear learning can become disproportionate in vulnerable individuals. Despite the potential clinical significance, the mechanism by which stress modulates fear learning is poorly understood...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2015.02.014

    authors： Vogel S,Klumpers F,Kroes MC,Oplaat KT,Krugers HJ,Oitzl MS,Joëls M,Fernández G

    更新日期：2015-12-15 00:00:00

  • The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: an evolutionary perspective.

    abstract：BACKGROUND:We recently described a preliminary association between the hypofunctional seven-repeat allele of the dopamine-4 receptor gene (DRD4) and increased maximal lifetime body mass index in women with seasonal affective disorder (SAD). In this study, we examined whether binge eating behavior mediated this putative...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.08.013

    authors： Levitan RD,Masellis M,Basile VS,Lam RW,Kaplan AS,Davis C,Muglia P,Mackenzie B,Tharmalingam S,Kennedy SH,Macciardi F,Kennedy JL

    更新日期：2004-11-01 00:00:00

  • Chronic antidepressant treatment impairs the acquisition of fear extinction.

    abstract：BACKGROUND:Like fear conditioning, the acquisition phase of extinction involves new learning that is mediated by the amygdala. During extinction training, the conditioned stimulus is repeatedly presented in the absence of the unconditioned stimulus, and the expression of previously learned fear gradually becomes suppre...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.10.012

    authors： Burghardt NS,Sigurdsson T,Gorman JM,McEwen BS,LeDoux JE

    更新日期：2013-06-01 00:00:00

  • Cerebrospinal fluid neuropeptides in dementia.

    abstract：:Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH) and somatostatin (SRIF) were measured in 77 female inpatients with moderate to extreme dementia and in 17 elderly female controls. Both multi-infarct (MID) and Alzheimer-type (SDAT) demented patients had eq...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90132-j

    authors： Banki CM,Karmacsi L,Bissette G,Nemeroff CB

    更新日期：1992-09-01 00:00:00

  • Myelin and axon abnormalities in schizophrenia measured with magnetic resonance imaging techniques.

    abstract：BACKGROUND:In schizophrenia (SZ), disturbances in integration of activity among brain regions seem to be as important as abnormal activity of any single region. Brain regions are connected through white matter (WM) tracts, and diffusion tensor imaging has provided compelling evidence for WM abnormalities in SZ. However...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.03.003

    authors： Du F,Cooper AJ,Thida T,Shinn AK,Cohen BM,Ongür D

    更新日期：2013-09-15 00:00:00

  • Fearful imagery in social phobia: generalization, comorbidity, and physiological reactivity.

    abstract：BACKGROUND:Social phobia has been characterized as a disorder of exaggerated fear of social threat and heightened sensitivity to imagery of social failure. METHODS:To assess the physiological basis of this description, social phobia patients (n=75) and demographically matched control participants (n=75) imagined neutr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.09.023

    authors： McTeague LM,Lang PJ,Laplante MC,Cuthbert BN,Strauss CC,Bradley MM

    更新日期：2009-03-01 00:00:00

  • The Functional Brain Organization of an Individual Allows Prediction of Measures of Social Abilities Transdiagnostically in Autism and Attention-Deficit/Hyperactivity Disorder.

    abstract：BACKGROUND:Autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD) are associated with complex changes as revealed by functional magnetic resonance imaging. To date, neuroimaging-based models are not able to characterize individuals with sufficient sensitivity and specificity. Further, although evi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.02.019

    authors： Lake EMR,Finn ES,Noble SM,Vanderwal T,Shen X,Rosenberg MD,Spann MN,Chun MM,Scheinost D,Constable RT

    更新日期：2019-08-15 00:00:00

  • Hypothesis testing: is clozapine's superior efficacy dependent on moderate D2 receptor occupancy?

    abstract：BACKGROUND:How clozapine exerts superior antipsychotic efficacy in treatment-resistant schizophrenia is not known. Moderate (rather than "full") occupancy of D2 postsynaptic receptors may be crucial, perhaps by achieving a more effective D1/D2 or serotonin-2a/D2 ratio. The objective of this study was to test the modera...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0006-3223(98)00226-1

    authors： Carpenter WT Jr,Zito JM,Vitrai J,Volavka J

    更新日期：1998-01-15 00:00:00

  • Modification of ligand binding to membranes by a soluble acceptor. Alpha-1-acid glycoprotein attenuates 3H-imipramine binding to cerebral membranes.

    abstract：:The effect of individual plasma proteins on the binding of 3H-imipramine (3H-IMI) was investigated, using rat cerebral membranes as the binding site source. Addition of alpha-1-acid glycoprotein (aAGLP) to an incubation medium containing 4 nm 3H-IMI resulted in a concentration-dependent inhibition of 3H-IMI binding, w...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(86)90261-1

    authors： Barkai AI,Baron M,Kowalik S,Cooper TB

    更新日期：1986-08-01 00:00:00

  • Elevated C-reactive protein, depression, somatic diseases, and all-cause mortality: a mendelian randomization study.

    abstract：BACKGROUND:Elevated levels of plasma C-reactive protein (CRP) have been associated with many diseases including depression, but it remains unclear whether this association is causal. We tested the hypothesis that CRP is causally associated with depression, and compared these results to those for cancer, ischemic heart ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.10.009

    authors： Wium-Andersen MK,Orsted DD,Nordestgaard BG

    更新日期：2014-08-01 00:00:00

  • Characterization of Single Gene Copy Number Variants in Schizophrenia.

    abstract：BACKGROUND:Genetic studies of schizophrenia have implicated numerous risk loci including several copy number variants (CNVs) of large effect and hundreds of loci of small effect. In only a few cases has a specific gene been clearly identified. Rare CNVs affecting a single gene offer a potential avenue to discovering sc...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.09.023

    authors： Szatkiewicz JP,Fromer M,Nonneman RJ,Ancalade N,Johnson JS,Stahl EA,Rees E,Bergen SE,Hultman CM,Kirov G,O'Donovan M,Owen M,Holmans P,Sklar P,Sullivan PF,Purcell SM,Crowley JJ,Ruderfer DM

    更新日期：2020-04-15 00:00:00

  • HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression.

    abstract：BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.10.008

    authors： Gotlib IH,Joormann J,Minor KL,Hallmayer J

    更新日期：2008-05-01 00:00:00

  • Reduced Brain Cannabinoid Receptor Availability in Schizophrenia.

    abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.08.021

    authors： Ranganathan M,Cortes-Briones J,Radhakrishnan R,Thurnauer H,Planeta B,Skosnik P,Gao H,Labaree D,Neumeister A,Pittman B,Surti T,Huang Y,Carson RE,D'Souza DC

    更新日期：2016-06-15 00:00:00

  • Effects of local application of dopaminergic drugs into the medial prefrontal cortex of rats on latent inhibition.

    abstract：:The involvement of the dopamine (DA) innervation of the medial prefrontal cortex (PFC) in attention was studied in a latent inhibition (LI) paradigm in rats. LI becomes evident by a retardation of conditioning to a stimulus after nonreinforced preexposure to that stimulus. LI is thought to reflect an animal's ability ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/S0006-3223(95)00595-1

    authors： Broersen LM,Heinsbroek RP,de Bruin JP,Olivier B

    更新日期：1996-12-01 00:00:00

  • Polygenic Risk Scores for Developmental Disorders, Neuromotor Functioning During Infancy, and Autistic Traits in Childhood.

    abstract：BACKGROUND:Impaired neuromotor development is often one of the earliest observations in children with autism spectrum disorder (ASD). We investigated whether a genetic predisposition to developmental disorders was associated with nonoptimal neuromotor development during infancy and examined the genetic correlation betw...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.06.006

    authors： Serdarevic F,Tiemeier H,Jansen PR,Alemany S,Xerxa Y,Neumann A,Robinson E,Hillegers MHJ,Verhulst FC,Ghassabian A

    更新日期：2020-01-15 00:00:00

  • Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD).

    abstract：BACKGROUND:Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated. METHODS:The first consecutive 1000 adult bipolar patients enrolled in the National Institute of Mental Hea...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.01.022

    authors： Perlis RH,Miyahara S,Marangell LB,Wisniewski SR,Ostacher M,DelBello MP,Bowden CL,Sachs GS,Nierenberg AA,STEP-BD Investigators.

    更新日期：2004-05-01 00:00:00

  • Enhanced orbitofrontal cortex function and lack of attentional bias to cocaine cues in recreational stimulant users.

    abstract：BACKGROUND:Although cocaine is known to be a highly addictive drug, there appears to be a select subset of individuals who are able to use the substance recreationally without developing dependence. These individuals do not report experiencing feelings of craving for cocaine, an important distinction from dependent use...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.05.019

    authors： Smith DG,Simon Jones P,Bullmore ET,Robbins TW,Ersche KD

    更新日期：2014-01-15 00:00:00

  • Convergence of Sex Differences and the Neuroimmune System in Autism Spectrum Disorder.

    abstract：:The male bias in autism spectrum disorder incidence is among the most extreme of all neuropsychiatric disorders, yet the origins of the sex difference remain obscure. Developmentally, males are exposed to high levels of testosterone and its byproduct, estradiol. Together these steroids modify the course of brain devel...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2016.10.004

    authors： McCarthy MM,Wright CL

    更新日期：2017-03-01 00:00:00

  • Frontoparietal Activation During Response Inhibition Predicts Remission to Antidepressants in Patients With Major Depression.

    abstract：BACKGROUND:Despite cognitive function impairment in depression, its relationship to treatment outcome is not well understood. Here, we examined whether pretreatment activation of cortical circuitry during test of cognitive functions predicts outcomes for three commonly used antidepressants. METHODS:Eighty medication-f...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2015.02.037

    authors： Gyurak A,Patenaude B,Korgaonkar MS,Grieve SM,Williams LM,Etkin A

    更新日期：2016-02-15 00:00:00

  • Event-related potentials in adolescents with schizophrenia and their siblings: a comparison with attention-deficit/hyperactivity disorder.

    abstract：BACKGROUND:Identifying trait markers specific to schizophrenia might uncover mechanisms underlying illness susceptibility. Previous research shows the N2 and P3 event-related potentials are abnormal in schizophrenia; specificity of these potential trait markers has not been well established. METHODS:Electroencephalogr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.biopsych.2007.09.018

    authors： Groom MJ,Bates AT,Jackson GM,Calton TG,Liddle PF,Hollis C

    更新日期：2008-04-15 00:00:00

  • Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience.

    abstract：:The intuitive association between self-focused rumination in major depressive disorder (MDD) and the self-referential operations performed by the brain's default-mode network (DMN) has prompted interest in examining the role of the DMN in MDD. In this article, we present meta-analytic findings showing reliably increas...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2015.02.020

    authors： Hamilton JP,Farmer M,Fogelman P,Gotlib IH

    更新日期：2015-08-15 00:00:00

  • Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia.

    abstract：BACKGROUND:Previous studies suggest circadian rhythm disturbances in children with attention-deficit/hyperactivity disorder (ADHD) and sleep-onset insomnia (SOI). We investigate here sleep and rhythms in activity and melatonin in adults with ADHD. METHODS:Sleep logs and actigraphy data were collected during 1 week in ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.12.032

    authors： Van Veen MM,Kooij JJ,Boonstra AM,Gordijn MC,Van Someren EJ

    更新日期：2010-06-01 00:00:00

  • Kinetics and Dose Dependency of Intranasal Oxytocin Effects on Amygdala Reactivity.

    abstract：BACKGROUND:Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2017.04.015

    authors： Spengler FB,Schultz J,Scheele D,Essel M,Maier W,Heinrichs M,Hurlemann R

    更新日期：2017-12-15 00:00:00

  • Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus.

    abstract：BACKGROUND:In view of the effects of stress on synaptic plasticity, the regulation of synaptophysin and synaptotagmin expression by immobilization was analyzed by in situ hybridization. METHODS:Rats were exposed to immobilization stress, which induced typical behavioral alterations, such as reduced locomotor activity ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01229-x

    authors： Thome J,Pesold B,Baader M,Hu M,Gewirtz JC,Duman RS,Henn FA

    更新日期：2001-11-15 00:00:00

  • Rapid dynamic CT scanning in primary degenerative dementia and age-matched controls.

    abstract：:Dynamic computed tomography (CT) scanning of the brain was performed in 26 patients with primary degenerative dementia (PDD) and in 15 age-matched controls without evidence of a dementing illness. Changes in CT density values over time were obtained for 16 regions of interest (ROIs) that were carefully chosen to avoid...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(90)90410-4

    authors： Dysken MW,Nelson MJ,Hoover KM,Kuskowski M,McGeachie R

    更新日期：1990-09-01 00:00:00