Abstract:
BACKGROUND:In schizophrenia (SZ), disturbances in integration of activity among brain regions seem to be as important as abnormal activity of any single region. Brain regions are connected through white matter (WM) tracts, and diffusion tensor imaging has provided compelling evidence for WM abnormalities in SZ. However, diffusion tensor imaging alone cannot currently pinpoint the biological basis of these abnormalities. METHODS:In this study, we combined a myelin-specific and an axon-specific magnetic resonance imaging approach to examine potentially distinct abnormalities of WM components in SZ. Magnetization transfer ratio (MTR) provides information on myelin content, whereas diffusion tensor spectroscopy provides information on metabolite diffusion within axons. We collected data from a 1 × 3 × 3 cm voxel within the right prefrontal cortex WM at 4 Tesla and studied 23 patients with SZ and 22 age- and sex-matched healthy control participants. RESULTS:The MTR was significantly reduced in SZ, suggesting reduced myelin content. By contrast, the apparent diffusion coefficient of N-acetylaspartate (NAA) was significantly elevated, suggesting intra-axonal abnormalities. Greater abnormality of both MTR and the apparent diffusion coefficient of NAA correlated with more adverse outcomes in the patient group. CONCLUSIONS:The results suggest that WM abnormalities in SZ include both abnormal myelination and abnormal NAA diffusion within axons. These processes might be associated with abnormal signal transduction and abnormal information processing in SZ.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Du F,Cooper AJ,Thida T,Shinn AK,Cohen BM,Ongür Ddoi
10.1016/j.biopsych.2013.03.003subject
Has Abstractpub_date
2013-09-15 00:00:00pages
451-7issue
6eissn
0006-3223issn
1873-2402pii
S0006-3223(13)00222-9journal_volume
74pub_type
杂志文章abstract::The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...
journal_title:Biological psychiatry
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.06.027
更新日期:2008-11-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
更新日期:1975-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
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更新日期:2017-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.07.024
更新日期:2007-08-15 00:00:00