当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Effect of tetrahydroaminoacridine on sleep in healthy subjects.

Effect of tetrahydroaminoacridine on sleep in healthy subjects.

Abstract：

:The present study investigated the impact of the cholinesterase inhibitor tetrahydroaminoacridine (THA; tacrine) on sleep in healthy subjects. According to the reciprocal interaction model of non-rapid eye movement (NREM) and REM sleep regulation, which postulates a primary role in cholinergic neurotransmission for the initiation and maintenance of REM sleep, it was expected that THA would lead to an earlier onset of REM sleep. In 12 healthy subjects aged from 21 to 50 years two different doses (20 mg, 40 mg) were administered 1 hour prior to bed time and compared to placebo. Only the higher dose of THA significantly shortened REM latency. No other significant effects on sleep architecture were observed, although administration of 40 mg tacrine was associated with a decrease in sleep efficiency and a prolongation of sleep latency. Blood plasma levels of tacrine and its metabolite 1-hydroxytacrine measured prior to sleep and during the first 90 min of sleep were significantly correlated with the onset of REM sleep in relation to the timing of drug administration (only for the 20 mg dose). The reversible cholinesterase inhibitor THA exerts effects on REM latency comparable to those observed with other cholinomimetic agents.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Riemann D,Lis S,Fritsch-Montero R,Meier T,Krieger S,Hohagen F,Berger M

doi

10.1016/0006-3223(95)00224-3

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

796-802

issue

9

eissn

0006-3223

issn

1873-2402

pii

0006-3223(95)00224-3

journal_volume

39

pub_type

临床试验,杂志文章,随机对照试验

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Monoamine metabolism during chronic benzodiazepine treatment and withdrawal.

    abstract：:Long-term normal-dose benzodiazepine treatment in seven patients was associated with reduced urinary excretion of MOPEG (4-hydroxy-3-methoxy-phenylglycol). Following the discontinuation of the drugs a characteristic withdrawal reaction occurred, with an increase towards normal values of the MOPEG excretion levels and ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Petursson H,Bond PA,Smith B,Lader MH

    更新日期：1983-02-01 00:00:00

  • The P3 auditory event-related brain potential indexes major personality traits.

    abstract：BACKGROUND:The amplitude of the auditory P3 event-related potential is reduced in patients with axes I and II disorders. Data regarding P3 amplitude and normal personality traits in healthy individuals have been inconsistent, however, although more extreme variants of dimensional traits such as neuroticism and extraver...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(00)01067-2

    authors： Gurrera RJ,O'Donnell BF,Nestor PG,Gainski J,McCarley RW

    更新日期：2001-06-01 00:00:00

  • Low birth weight and neurocognitive status at six years of age.

    abstract：:We examined the relationship between low birth weight (LBW) (< or = 2500 g) and specific neurocognitive abilities at 6 years of age in a large-scale nonconcurrent prospective study. In 1990-1992, we randomly selected and evaluated LBW and normal birth weight (NBW) children from the 1983-1985 newborn lists of two major...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0006-3223(95)00399-1

    authors： Breslau N,Chilcoat H,DelDotto J,Andreski P,Brown G

    更新日期：1996-09-01 00:00:00

  • Greater cortical gray matter density in lithium-treated patients with bipolar disorder.

    abstract：BACKGROUND:The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures. METHODS:We used...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.10.027

    authors： Bearden CE,Thompson PM,Dalwani M,Hayashi KM,Lee AD,Nicoletti M,Trakhtenbroit M,Glahn DC,Brambilla P,Sassi RB,Mallinger AG,Frank E,Kupfer DJ,Soares JC

    更新日期：2007-07-01 00:00:00

  • Cord Serum Cytokines at Birth and Children's Anxiety-Depression Trajectories From 3 to 8 Years: The EDEN Mother-Child Cohort.

    abstract：BACKGROUND:Recent research suggests that immune dysregulation in pregnancy could be a risk factor for anxiety and depression symptoms in offspring. Whereas animal studies have demonstrated the importance of the link between perinatal cytokines and abnormal behaviors in offspring, human epidemiological studies in this a...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2020.10.009

    authors： Galera C,Barbosa S,Collet O,Khalfallah O,Aouizerate B,Sutter-Dalley AL,Koehl M,Capuron L,Van der Waerden J,Melchior M,Côté S,Heude B,Glaichenhaus N,Davidovic L,EDEN Mother–Child Cohort Study Group.

    更新日期：2020-10-24 00:00:00

  • Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease.

    abstract：:Psychiatric and neurologic disorders ranging from mental retardation to addiction are accompanied by structural and functional alterations of synaptic connections in the brain. Such alterations include abnormal density and morphology of dendritic spines, synapse loss, and aberrant synaptic signaling and plasticity. Re...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2003.10.006

    authors： Blanpied TA,Ehlers MD

    更新日期：2004-06-15 00:00:00

  • Early and late components of error monitoring in violent offenders with psychopathy.

    abstract：BACKGROUND:One of the most recognizable features of psychopathy is the reduced ability to successfully learn and adapt overt behavior. This might be due to deficient processing of error information indicating the need to adapt controlled behavior. METHODS:Event-related potentials (ERPs) and behavioral components of er...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.08.011

    authors： Brazil IA,de Bruijn ER,Bulten BH,von Borries AK,van Lankveld JJ,Buitelaar JK,Verkes RJ

    更新日期：2009-01-15 00:00:00

  • From early to late adulthood. Changes in EEG sleep of depressed patients and healthy volunteers.

    abstract：:In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(91)90355-p

    authors： Lauer CJ,Riemann D,Wiegand M,Berger M

    更新日期：1991-05-15 00:00:00

  • Fluoxetine and neuroleptic malignant syndrome.

    abstract：:The authors present a case report of neuroleptic malignant syndrome (NMS) in a patient commencing treatment with fluoxetine alone who had previously been treated with several antipsychotic and antidepressant combinations. On reviewing the literature on the pathogenesis of NMS, the authors hypothesize a facilitative ro...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(90)90485-k

    authors： Halman M,Goldbloom DS

    更新日期：1990-09-15 00:00:00

  • Abnormalities of brain structure and density in schizophrenia.

    abstract：:Quantitative and qualitative measures of brain morphology were derived through CT scans using computer-assisted methodology in patients with schizophrenia or schizo-affective psychosis and headache controls. Schizophrenics had significantly higher density of white matter, together with greater right vs. left asymmetry...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Largen JW Jr,Smith RC,Calderon M,Baumgartner R,Lu RB,Schoolar JC,Ravichandran GK

    更新日期：1984-07-01 00:00:00

  • Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents.

    abstract：BACKGROUND:Binge eating and other forms of disordered eating behavior (DEB) are associated with failed inhibitory control. This study investigated the neural correlates of failed inhibitory control as a potential biomarker for DEB. METHODS:The study used prospective longitudinal data from the European IMAGEN study ado...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.01.027

    authors： Bartholdy S,O'Daly OG,Campbell IC,Banaschewski T,Barker G,Bokde ALW,Bromberg U,Büchel C,Quinlan EB,Desrivières S,Flor H,Frouin V,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,Paillère Martinot ML,Nees F,Orfano

    更新日期：2019-06-01 00:00:00

  • Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay.

    abstract：BACKGROUND:A number of investigators have reported finding elevated basal and stimulated intracellular calcium levels in the platelets or lymphocytes of bipolar disorder patients. METHODS:Intracellular calcium was measured by a micro fura-2 fluorometric method in the platelets and lymphocytes of 30 affective disorder ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00308-4

    authors： Hough C,Lu SJ,Davis CL,Chuang DM,Post RM

    更新日期：1999-07-15 00:00:00

  • Amygdala responses to human faces in obsessive-compulsive disorder.

    abstract：BACKGROUND:To assess the amygdala response to emotional faces in obsessive-compulsive disorder (OCD) using functional magnetic resonance imaging (fMRI). METHODS:Ten subjects with current OCD and 10 healthy control subjects underwent fMRI, during which they viewed pictures of fearful, happy, and neutral human faces, as...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.09.029

    authors： Cannistraro PA,Wright CI,Wedig MM,Martis B,Shin LM,Wilhelm S,Rauch SL

    更新日期：2004-12-15 00:00:00

  • Connectomic disturbances in attention-deficit/hyperactivity disorder: a whole-brain tractography analysis.

    abstract：BACKGROUND:Few studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturban...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.12.013

    authors： Hong SB,Zalesky A,Fornito A,Park S,Yang YH,Park MH,Song IC,Sohn CH,Shin MS,Kim BN,Cho SC,Han DH,Cheong JH,Kim JW

    更新日期：2014-10-15 00:00:00

  • Depression in Alzheimer's disease: heterogeneity and related issues.

    abstract：:Several studies have demonstrated that the great majority of Alzheimer's disease (AD) patients suffer "noncognitive" neuropsychiatric symptoms. Depression is one of the most frequent neuropsychiatric comorbidities of AD. Affecting up to 50% of AD patients, depression in AD is associated with serious negative consequen...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(03)00543-2

    authors： Lee HB,Lyketsos CG

    更新日期：2003-08-01 00:00:00

  • Vulnerability factors among children at risk for anxiety disorders.

    abstract：BACKGROUND:The high-risk strategy is one of the most powerful approaches for identifying premorbid risk factors and reducing etiologic and phenotypic heterogeneity characteristic of the major psychiatric disorders. METHODS:This paper reviews the methods of high-risk research and findings from previous high-risk studie...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(99)00172-9

    authors： Merikangas KR,Avenevoli S,Dierker L,Grillon C

    更新日期：1999-12-01 00:00:00

  • Localized enlargement of the frontal cortex in early autism.

    abstract：BACKGROUND:Evidence from behavioral, imaging, and postmortem studies indicates that the frontal lobe, as well as other brain regions such as the cerebellum and limbic system, develops abnormally in children with autism. It is not yet clear to what extent the frontal lobe is affected; that is, whether all regions of fro...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2004.11.005

    authors： Carper RA,Courchesne E

    更新日期：2005-01-15 00:00:00

  • Smaller orbital frontal cortex volumes associated with functional disability in depressed elders.

    abstract：BACKGROUND:Depression is associated with significant functional impairment. Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living. METHODS:The ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01490-7

    authors： Taylor WD,Steffens DC,McQuoid DR,Payne ME,Lee SH,Lai TJ,Krishnan KR

    更新日期：2003-01-15 00:00:00

  • Influence of vincamine and piracetam on sleep--waking pattern of the cat.

    abstract：:The effect of Vincamine and Piracetam, two geriatric drugs, on sleep behavior of the laboratory cat was studied. The animals were chronically prepared for recording of the EEG of the cerebral cortex, the lateral geniculate body, and the hippocampus, and for recording of eye movements, the muscular tonus and respiratio...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Glatt A,Klebs K,Koella WP

    更新日期：1978-08-01 00:00:00

  • Cardiovascular effects of mixed amphetamine salts extended release in the treatment of school-aged children with attention-deficit/hyperactivity disorder.

    abstract：BACKGROUND:The cardiovascular safety of mixed amphetamine salts extended release (MAS XR) was evaluated in 2968 children 6-12 years of age with attention-deficit/hyperactivity disorder (ADHD). METHODS:In this prospective, open-label, noncomparative, community-based study, subjects whose symptoms of ADHD were well cont...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.05.002

    authors： Donner R,Michaels MA,Ambrosini PJ

    更新日期：2007-03-01 00:00:00

  • Differential sex-independent amygdala response to infant crying and laughing in parents versus nonparents.

    abstract：BACKGROUND:Animal and human studies implicate forebrain neural circuits in maternal behavior. Here, we hypothesized that human brain response to emotional stimuli relevant for social interactions between infants and adults are modulated by sex- and experience-dependent factors. METHODS:We used functional magnetic reso...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00697-8

    authors： Seifritz E,Esposito F,Neuhoff JG,Lüthi A,Mustovic H,Dammann G,von Bardeleben U,Radue EW,Cirillo S,Tedeschi G,Di Salle F

    更新日期：2003-12-15 00:00:00

  • Limbic/mesolimbic connections and the pathogenesis of schizophrenia.

    abstract：:The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/0006-3223(91)90295-w

    authors： Csernansky JG,Murphy GM,Faustman WO

    更新日期：1991-08-15 00:00:00

  • Long-term social recognition memory is mediated by oxytocin-dependent synaptic plasticity in the medial amygdala.

    abstract：BACKGROUND:Recognition of specific individuals is fundamental to mammalian social behavior and is mediated in most mammals by the main and accessory olfactory systems. Both these systems innervate the medial amygdala (MeA), where activity of the neuropeptide oxytocin is thought to mediate social recognition memory (SRM...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.03.022

    authors： Gur R,Tendler A,Wagner S

    更新日期：2014-09-01 00:00:00

  • A fenfluramine-activated FDG-PET study of borderline personality disorder.

    abstract：BACKGROUND:Impulsive aggression in patients with personality disorders is associated with diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to serotonergic agonists, and decreased glucose utilization in the prefrontal cortex. We tested the hypothesis that impulsive aggression in bo...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(99)00202-4

    authors： Soloff PH,Meltzer CC,Greer PJ,Constantine D,Kelly TM

    更新日期：2000-03-15 00:00:00

  • ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: results of a pilot study.

    abstract：BACKGROUND:This pilot study was designed to evaluate ABT-089, a neuronal nicotinic receptor partial agonist, as treatment for adult attention-deficit/hyperactivity disorder (ADHD). METHODS:Adults with ADHD received placebo, 2 mg, 4 mg, or 20 mg of ABT-089 for 2 weeks each in a randomized, double-blind, placebo-control...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2005.10.029

    authors： Wilens TE,Verlinden MH,Adler LA,Wozniak PJ,West SA

    更新日期：2006-06-01 00:00:00

  • Hypertonic hemolysis in patients with a mood disorder.

    abstract：:Hypertonic hemolysis was increased in patients with a manic episode (n = 6, mean NaCl concentration in mol/L at which 50% of the erythrocytes was hemolyzed (H50) 3.24 +/- 0.10), compared to healthy controls (n = 12, mean H50 3.43 +/- 0.13) (p < or = 0.02) and patients with a nonaffective psychotic disorder (n = 15, me...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(95)00106-9

    authors： Hoeksema T,Goekoop JG,Van Kempen GM

    更新日期：1996-01-01 00:00:00

  • Anxiety-like state associates with taste to produce conditioned taste aversion.

    abstract：BACKGROUND:The interactions among experience, emotion, and memory are considered to be instrumental in the ontogeny and maintenance of acquired emotional and behavioral disorders (e.g., phobias). Here we address the question whether an anxiety-like state can associate with taste to produce conditioned taste aversion (C...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.08.024

    authors： Guitton MJ,Dudai Y

    更新日期：2004-12-01 00:00:00

  • Harnessing Gut Microbes for Mental Health: Getting From Here to There.

    abstract：:There has been an explosion of interest in the study of microorganisms inhabiting the gastrointestinal tract (gut microbiota) and their impact on host health and physiology. Accumulating data suggest that altered communication between gut microbiota and host systems could participate in disorders such as obesity, diab...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2017.08.014

    authors： Bruce-Keller AJ,Salbaum JM,Berthoud HR

    更新日期：2018-02-01 00:00:00

  • Deficit psychopathology and a paradigm shift in schizophrenia research.

    abstract：:Despite recognition that schizophrenia must have syndrome status in the absence of proof of a single etiopathophysiologic process, a century of work has been based on designs that conceptualize schizophrenia as a single disease entity. Reducing heterogeneity at several levels of functioning is desirable. In this artic...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(99)00088-8

    authors： Carpenter WT Jr,Arango C,Buchanan RW,Kirkpatrick B

    更新日期：1999-08-01 00:00:00

  • Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events.

    abstract：BACKGROUND:Recently, it has been reported that serum interleukin-1 beta (IL-1 beta), but not soluble IL-2 receptor (sIL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00131-0

    authors： Maes M,Lin AH,Delmeire L,Van Gastel A,Kenis G,De Jongh R,Bosmans E

    更新日期：1999-04-01 00:00:00