当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: results of a pilot study.

ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: results of a pilot study.

Abstract：

BACKGROUND:This pilot study was designed to evaluate ABT-089, a neuronal nicotinic receptor partial agonist, as treatment for adult attention-deficit/hyperactivity disorder (ADHD). METHODS:Adults with ADHD received placebo, 2 mg, 4 mg, or 20 mg of ABT-089 for 2 weeks each in a randomized, double-blind, placebo-controlled, 4 x 4 Latin square design for a total of 8 weeks. In addition to the primary outcome, the Conner's Adult ADHD Rating Scale (CAARS), secondary rating scales, and neuropsychological and safety assessments were completed. RESULTS:A total of 11 adults with well-characterized ADHD completed this crossover study. ABT-089 b.i.d. was superior to placebo for the CAARS Total Symptom Score, which was the primary endpoint (placebo: 38.0 +/- 1.9; 2 mg b.i.d.: 32.2 +/- 1.9, one-tail p = .021; 4 mg b.i.d.: 33.2 +/- 1.9, p = .047; 20 mg b.i.d.: 33.5 +/- 1.9, p = .056). ABT-089 was also superior to placebo for the CAARS ADHD Index and Hyperactive/Impulsive scores and the Clinical Global Impression-ADHD Severity score. On the clinical efficacy endpoints, CAARS Total Symptom Score and CAARS Hyperactive/Impulsive score, a shallow inverted U-shaped dose-response curve was observed; however, the dose-response curve for attention and memory effects as measured by computerized cognitive testing seemed dose-linear. No clinically meaningful findings in safety assessments or side effect profile were observed. CONCLUSIONS:Data from this pilot study suggest that ABT-089 might be effective in treating adult ADHD and that it is well tolerated. On the basis of these promising results, larger, parallel-group ABT-089 studies of longer duration are warranted.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Wilens TE,Verlinden MH,Adler LA,Wozniak PJ,West SA

doi

10.1016/j.biopsych.2005.10.029

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

1065-70

issue

11

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(05)01442-3

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary report.

    abstract：BACKGROUND:In the Systematic Treatment Enhancement Program for Bipolar Disorder, we showed that valproate is associated with new-onset menstrual-cycle irregularities and hyperandrogenism in 10.5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation. ME...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.05.027

    authors： Joffe H,Cohen LS,Suppes T,Hwang CH,Molay F,Adams JM,Sachs GS,Hall JE

    更新日期：2006-12-15 00:00:00

  • Timing is everything: the onset of depression and acute coronary syndrome outcome.

    abstract：BACKGROUND:Conflicting findings have emerged from studies examining the impact of depression on death and readmission following a coronary event, possibly reflecting differences in the measurement of "depression" and the onset of depression in relation to the coronary event. The aim of this study was to examine the rel...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.05.021

    authors： Parker GB,Hilton TM,Walsh WF,Owen CA,Heruc GA,Olley A,Brotchie H,Hadzi-Pavlovic D

    更新日期：2008-10-15 00:00:00

  • Are there differences in the symptoms that respond to a selective serotonin or norepinephrine reuptake inhibitor?

    abstract：BACKGROUND:We examined two previously published studies comparing a norepinephrine (NE) selective agent, reboxetine, and a serotonin (5-HT) selective agent, fluoxetine, to determine if these agents have different effects on individual depressive symptoms. METHODS:Both studies were 8-week, double-blind, comparison stud...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2005.03.030

    authors： Nelson JC,Portera L,Leon AC

    更新日期：2005-06-15 00:00:00

  • Serum thyroxine change and clinical recovery in psychiatric inpatients.

    abstract：:Serum free thyroxine (FT4), total thyroxine (TT4), and Brief Psychiatric Rating Scale (BPRS) measurements were obtained following hospital admission and at 2-week intervals during hospitalization in 80 male psychiatric inpatients with a variety of major psychotic and affective disorders. A strong correlation between t...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(89)90148-0

    authors： Southwick S,Mason JW,Giller EL,Kosten TR

    更新日期：1989-01-01 00:00:00

  • Effect of phenytoin on mood and declarative memory during prescription corticosteroid therapy.

    abstract：BACKGROUND:In humans and animals, corticosteroid excess is associated with impairment in declarative memory and changes in hippocampal structure. In animals, phenytoin pretreatment blocks the effects of stress on memory and hippocampal histology, although no studies have examined the use of phenytoin to prevent cortico...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2004.11.021

    authors： Brown ES,Stuard G,Liggin JD,Hukovic N,Frol A,Dhanani N,Khan DA,Jeffress J,Larkin GL,McEwen BS,Rosenblatt R,Mageto Y,Hanczyc M,Cullum CM

    更新日期：2005-03-01 00:00:00

  • Differential effect of haloperidol and clozapine on plasma homovanillic acid in elderly schizophrenic patients with or without tardive dyskinesia.

    abstract：BACKGROUND:Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment. METHODS:Twenty-six elderly women who gave informed consent were divided into two groups, with or w...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0006-3223(97)00257-6

    authors： Andia I,Zumarraga M,Zabalo MJ,Bulbena A,Davila R

    更新日期：1998-01-01 00:00:00

  • Early and late components of error monitoring in violent offenders with psychopathy.

    abstract：BACKGROUND:One of the most recognizable features of psychopathy is the reduced ability to successfully learn and adapt overt behavior. This might be due to deficient processing of error information indicating the need to adapt controlled behavior. METHODS:Event-related potentials (ERPs) and behavioral components of er...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.08.011

    authors： Brazil IA,de Bruijn ER,Bulten BH,von Borries AK,van Lankveld JJ,Buitelaar JK,Verkes RJ

    更新日期：2009-01-15 00:00:00

  • Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease.

    abstract：BACKGROUND:Reduction of precuneus choline acetyltransferase activity co-occurs with greater beta-amyloid (Aβ) in Alzheimer's disease (AD). Whether this cholinergic deficit is associated with alteration in nerve growth factor (NGF) signaling and its relation to Aβ plaque and neurofibrillary tangle (NFT) pathology during...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.12.016

    authors： Perez SE,He B,Nadeem M,Wuu J,Scheff SW,Abrahamson EE,Ikonomovic MD,Mufson EJ

    更新日期：2015-04-15 00:00:00

  • Aversive stimuli drive drug seeking in a state of low dopamine tone.

    abstract：BACKGROUND:Stressors negatively impact emotional state and drive drug seeking, in part, by modulating the activity of the mesolimbic dopamine system. Unfortunately, the rapid regulation of dopamine signaling by the aversive stimuli that cause drug seeking is not well characterized. In a series of experiments, we scruti...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.09.004

    authors： Twining RC,Wheeler DS,Ebben AL,Jacobsen AJ,Robble MA,Mantsch JR,Wheeler RA

    更新日期：2015-05-15 00:00:00

  • Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment.

    abstract：:Parental stress exposures are implicated in the risk for offspring neurodevelopmental and neuropsychiatric disorders, prompting critical examination of preconception and prenatal periods as vulnerable to environmental insults such as stress. Evidence from human studies and animal models demonstrates the influence that...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2017.10.005

    authors： Chan JC,Nugent BM,Bale TL

    更新日期：2018-05-15 00:00:00

  • Effect of chronic antipsychotic treatment on brain structure: a serial magnetic resonance imaging study with ex vivo and postmortem confirmation.

    abstract：BACKGROUND:There is increasing evidence that antipsychotic (APD) may affect brain structure directly. To examine this, we developed a rodent model that uses clinically relevant doses and serial magnetic resonance imaging (MRI), followed by postmortem histopathological analysis to study the effects of APD on brain struc...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.11.010

    authors： Vernon AC,Natesan S,Modo M,Kapur S

    更新日期：2011-05-15 00:00:00

  • Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder.

    abstract：BACKGROUND:Anatomic magnetic resonance imaging (MRI) studies of attention-deficit/hyperactivity disorder (ADHD) have been limited by use of callosal rather than sulcal/gyral landmarks in defining cerebral lobes and functionally relevant sublobar regions (e.g., prefrontal cortex). We present an investigation of cerebral...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01412-9

    authors： Mostofsky SH,Cooper KL,Kates WR,Denckla MB,Kaufmann WE

    更新日期：2002-10-15 00:00:00

  • Dopaminergic function in panic disorder: comparison with major and minor depression.

    abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90061-4

    authors： Pitchot W,Ansseau M,Gonzalez Moreno A,Hansenne M,von Frenckell R

    更新日期：1992-12-01 00:00:00

  • Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia.

    abstract：BACKGROUND:Neurocognitive deficits are recognized as a cardinal feature of schizophrenia, but the determinants of these deficits remain unknown. Recent reports have suggested that a functional polymorphism, Val(158)Met in exon III of the catechol-O-methyltransferase gene, shares approximately 4% variance with performan...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01416-6

    authors： Bilder RM,Volavka J,Czobor P,Malhotra AK,Kennedy JL,Ni X,Goldman RS,Hoptman MJ,Sheitman B,Lindenmayer JP,Citrome L,McEvoy JP,Kunz M,Chakos M,Cooper TB,Lieberman JA

    更新日期：2002-10-01 00:00:00

  • The HPA axis response to insulin hypoglycemia in depression.

    abstract：:Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, demonstrated by failure to suppress cortisol secretion after dexamethasone, is found in approximately 50% of patients with major depression (MD). In this study, we examined the response of adrenocorticotrophic hormone (ACTH) and cortisol to insulin-induced ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(87)90226-5

    authors： Lopez JF,Kathol RG,Jaeckle RS,Meller W

    更新日期：1987-02-01 00:00:00

  • Developing novel treatments for mood disorders: accelerating discovery.

    abstract：:This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad stroke...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(02)01470-1

    authors： Tamminga CA,Nemeroff CB,Blakely RD,Brady L,Carter CS,Davis KL,Dingledine R,Gorman JM,Grigoriadis DE,Henderson DC,B Innis RB,Killen J,Laughren TP,McDonald WM,M Murphy GM Jr,Paul SM,Rudorfer MV,Sausville E,Schatzberg AF

    更新日期：2002-09-15 00:00:00

  • Neural responses to sad facial expressions in major depression following cognitive behavioral therapy.

    abstract：BACKGROUND:Affective facial processing is an important component of interpersonal relationships. The neural substrate has been examined following treatment with antidepressant medication but not with psychological therapies. The present study investigated the neural correlates of implicit processing of sad facial expre...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.04.033

    authors： Fu CH,Williams SC,Cleare AJ,Scott J,Mitterschiffthaler MT,Walsh ND,Donaldson C,Suckling J,Andrew C,Steiner H,Murray RM

    更新日期：2008-09-15 00:00:00

  • Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice.

    abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is th...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.05.011

    authors： Pinhal CM,van den Boom BJG,Santana-Kragelund F,Fellinger L,Bech P,Hamelink R,Feng G,Willuhn I,Feenstra MGP,Denys D

    更新日期：2018-12-15 00:00:00

  • Neurochemical abnormalities in anorexia nervosa: similarities to affective disorders.

    abstract：:Certain investigators have asserted that the illness of anorexia nervosa is a form of hypothalamic disturbance. The relationship between 24-hr urine 3-methoxy-4-hydroxyphenylglycol (MHPG) and dexamethasone suppression tests was examined in 13 female patients with AN diagnosed by RDC. Patients showed a consistent assoc...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Gwirtsman HE,Gerner RH

    更新日期：1981-10-01 00:00:00

  • Predictors of the course of tardive dyskinesia in patients receiving neuroleptics.

    abstract：:As many patients still require maintenance neuroleptic medication, it is important to determine what factors affect the course of tardive dyskinesia (TD) during ongoing neuroleptic treatment. In this study the data are from a series of annual examinations using the Abnormal Involuntary Movement Scale (AIMS) in a cohor...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90071-7

    authors： Bergen J,Kitchin R,Berry G

    更新日期：1992-10-01 00:00:00

  • Multiscale Neuroscience of Psychiatric Disorders.

    abstract：:The human brain comprises a multiscale network with multiple levels of organization. Neurons with dendritic and axonal connections form the microscale fabric of brain circuitry, and macroscale brain regions and white matter connections form the infrastructure for system-level brain communication and information integr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2019.05.015

    authors： van den Heuvel MP,Scholtens LH,Kahn RS

    更新日期：2019-10-01 00:00:00

  • Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events.

    abstract：BACKGROUND:Recently, it has been reported that serum interleukin-1 beta (IL-1 beta), but not soluble IL-2 receptor (sIL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secr...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(98)00131-0

    authors： Maes M,Lin AH,Delmeire L,Van Gastel A,Kenis G,De Jongh R,Bosmans E

    更新日期：1999-04-01 00:00:00

  • Chronic antidepressant treatment impairs the acquisition of fear extinction.

    abstract：BACKGROUND:Like fear conditioning, the acquisition phase of extinction involves new learning that is mediated by the amygdala. During extinction training, the conditioned stimulus is repeatedly presented in the absence of the unconditioned stimulus, and the expression of previously learned fear gradually becomes suppre...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.10.012

    authors： Burghardt NS,Sigurdsson T,Gorman JM,McEwen BS,LeDoux JE

    更新日期：2013-06-01 00:00:00

  • Effect of neuroleptic withdrawal on plasma prolactin: a possible marker of receptor adaptation.

    abstract：:Stable schizophrenic and schizoaffective outpatients underwent abrupt withdrawal from a fixed dose of neuroleptic. Prolactin concentrations were determined preceding and following drug withdrawal. Basal prolactin concentrations were significantly lower 3, 4, or 5 days following drug withdrawal than on subsequent days....

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(89)90016-4

    authors： Kirkpatrick B,Buchanan RW,Maeda K,Carpenter WT Jr,Jauch D,Tamminga CA

    更新日期：1989-06-01 00:00:00

  • Neonatal lesions of the ventral hippocampal formation alter GABA-A receptor subunit mRNA expression in adult rat frontal pole.

    abstract：BACKGROUND:Gamma-aminobutyric acid (GABA)-ergic function is altered in schizophrenia. Of particular interest is the altered central nervous system expression of GABA-A receptor subunits, as changes in subunit expression account for recognized differences in mammalian brain function making them inviting targets for nove...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.09.017

    authors： Mitchell CP,Grayson DR,Goldman MB

    更新日期：2005-01-01 00:00:00

  • Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia.

    abstract：BACKGROUND:The etiology of dementia that occurs in patients with schizophrenia is not well understood. Nicotinic acetylcholine receptors have been implicated in cognitive function, and deficits in these receptors have been reported in schizophrenia. METHODS:The present study investigates possible associations of nicot...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00348-2

    authors： Martin-Ruiz CM,Haroutunian VH,Long P,Young AH,Davis KL,Perry EK,Court JA

    更新日期：2003-12-01 00:00:00

  • Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations.

    abstract：:This paper is not a comprehensive review of the literature. Rather, it is a viewpoint based upon advances in other fields of medicine and genetics that may provide a model for guiding research in psychiatry. The paper discusses the major limitations of the medicines currently used to treat schizophrenia and bipolar il...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2006.02.022

    authors： Scolnick EM

    更新日期：2006-06-01 00:00:00

  • Elevated expression of integrin alpha(IIb) beta(IIIa) in drug-naïve, first-episode schizophrenic patients.

    abstract：BACKGROUND:Patients with schizophrenia have an increased risk over the general public of developing cardiovascular illness. It is unknown if there are functional changes in platelet surface receptors in schizophrenia. We therefore analyzed the surface expression of glycoprotein (GP)Ib, the integrin receptor alpha(IIb)b...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01400-2

    authors： Walsh MT,Ryan M,Hillmann A,Condren R,Kenny D,Dinan T,Thakore JH

    更新日期：2002-11-01 00:00:00

  • Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval.

    abstract：:Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to wh...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(89)90215-1

    authors： Nagamoto HT,Adler LE,Waldo MC,Freedman R

    更新日期：1989-03-01 00:00:00

  • Three and six-month outcome following courses of either ECT or rTMS in a population of severely depressed individuals--preliminary report.

    abstract：BACKGROUND:Recent studies have strengthened the claim that repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depression. The longitudinal outcome of TMS-treated patients, however, has not been described. We report on the 3- and 6-month outcomes of a group of patients treated with e...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0006-3223(01)01274-4

    authors： Dannon PN,Dolberg OT,Schreiber S,Grunhaus L

    更新日期：2002-04-15 00:00:00