Abstract:
BACKGROUND:Affective facial processing is an important component of interpersonal relationships. The neural substrate has been examined following treatment with antidepressant medication but not with psychological therapies. The present study investigated the neural correlates of implicit processing of sad facial expressions in depression pretreatment and posttreatment with cognitive behavioral therapy (CBT). METHODS:The patient group consisted of 16 medication-free subjects (mean age 40 years) with a DSM-IV diagnosis of acute unipolar major depression, and the comparison group were 16 matched healthy volunteers. Subjects participated in a prospective study with functional magnetic resonance imaging (fMRI) at weeks 0 and 16. During the fMRI scans, subjects performed an affect recognition task with facial stimuli morphed to display varying intensities of sadness. Patients received 16 sessions of CBT. Functional magnetic resonance imaging data were analyzed for the mean activation and differential response to variable intensity (load-response) of facial affect processing. RESULTS:During an acute depressive episode, patients showed elevated amygdala-hippocampal activity relative to healthy individuals. Baseline dorsal anterior cingulate activity in patients showed a significant relationship with subsequent clinical response. CONCLUSIONS:These data provide further support for elevated amygdala activity in depression and suggest that anterior cingulate activity may be a predictor of treatment response to both pharmacotherapy and CBT.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Fu CH,Williams SC,Cleare AJ,Scott J,Mitterschiffthaler MT,Walsh ND,Donaldson C,Suckling J,Andrew C,Steiner H,Murray RMdoi
10.1016/j.biopsych.2008.04.033subject
Has Abstractpub_date
2008-09-15 00:00:00pages
505-12issue
6eissn
0006-3223issn
1873-2402pii
S0006-3223(08)00565-9journal_volume
64pub_type
杂志文章abstract::Several studies have demonstrated that the great majority of Alzheimer's disease (AD) patients suffer "noncognitive" neuropsychiatric symptoms. Depression is one of the most frequent neuropsychiatric comorbidities of AD. Affecting up to 50% of AD patients, depression in AD is associated with serious negative consequen...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
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journal_title:Biological psychiatry
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journal_title:Biological psychiatry
pub_type: 杂志文章,多中心研究
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更新日期:2004-09-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2005.10.010
更新日期:2006-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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更新日期:2018-02-01 00:00:00
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doi:10.1016/0006-3223(92)90143-n
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-08-01 00:00:00
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更新日期:2001-04-15 00:00:00
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pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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更新日期:1998-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.biopsych.2007.04.040
更新日期:2007-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01323-3
更新日期:2002-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90222-8
更新日期:1991-02-15 00:00:00
abstract::The long-term test-retest reliability of event-related potentials (ERP) measures was examined in a group of 44 controls and 71 chronic alcoholics, retested after an average of 14 months. Correlational analyses revealed moderately significant test-retest correlations for visual and auditory target N1, N2, and P3 amplit...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90060-d
更新日期:1992-12-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90050-a
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a psychiatric condition that typically manifests in compulsive urges to perform irrational or excessive avoidance behaviors. A recent account has suggested that compulsivity in OCD might arise from excessive stimulus-response habit formation, rendering behavior insensit...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.02.002
更新日期:2014-04-15 00:00:00