Abstract：
:The human brain comprises a multiscale network with multiple levels of organization. Neurons with dendritic and axonal connections form the microscale fabric of brain circuitry, and macroscale brain regions and white matter connections form the infrastructure for system-level brain communication and information integration. In this review, we discuss the emerging trend of multiscale neuroscience, the multidisciplinary field that brings together data from these different levels of nervous system organization to form a better understanding of between-scale relationships of brain structure, function, and behavior in health and disease. We provide a broad overview of this developing field and discuss recent findings of exemplary multiscale neuroscience studies that illustrate the importance of studying cross-scale interactions among the genetic, molecular, cellular, and macroscale levels of brain circuitry and connectivity and behavior. We particularly consider a central, overarching goal of these multiscale neuroscience studies of human brain connectivity: to obtain insight into how disease-related alterations at one level of organization may underlie alterations observed at other scales of brain network organization in mental disorders. We conclude by discussing the current limitations, challenges, and future directions of the field.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
van den Heuvel MP,Scholtens LH,Kahn RSdoi
10.1016/j.biopsych.2019.05.015subject
Has Abstractpub_date
2019-10-01 00:00:00pages
512-522issue
7eissn
0006-3223issn
1873-2402pii
S0006-3223(19)31384-8journal_volume
86pub_type
杂志文章,评审abstract：:Social phobia (or "social anxiety disorder") is a prevalent condition that has been the subject of increased scrutiny in recent years. The purpose of this paper is to review the neurobiology of social phobia. It is apparent from the extant literature that this disorder is poorly understood from a neurobiological persp...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(98)00265-0
更新日期：1998-12-15 00:00:00
abstract：:The sleep parameters of never-depressed borderline subjects and age- and sex-matched normal controls were compared by continuous 48-hr ambulatory electroencephalographic (EEG) monitoring. Borderline subjects had a significantly shorter rapid eye movement latency, normal architecture of rapid eye movements sleep, and h...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0006-3223(93)90321-4
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Cognitive abnormalities are increasingly recognized as a feature of bipolar I disorder (BDI,) but there is limited information regarding the pattern and severity of cognitive impairment during remission and its relationship with clinical variables. METHODS:Forty-four remitted BDI patients recruited from a r...
journal_title：Biological psychiatry
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doi：10.1016/j.biopsych.2005.04.056
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Decreased hippocampal volume is observed in patients with Cushing's syndrome and other conditions associated with elevated cortisol levels, stress, or both. Reversibility of hippocampal neuronal atrophy resulting from stress occurs in animals. Our study investigated the potential for reversibility of human h...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(99)00203-6
更新日期：1999-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.biopsych.2003.10.004
更新日期：2004-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00004-9
更新日期：1999-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/0006-3223(90)90591-o
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journal_title：Biological psychiatry
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doi：10.1016/0006-3223(92)90338-z
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00302-8
更新日期：1998-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2010-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(00)01003-9
更新日期：2000-12-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90034-0
更新日期：1988-02-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2006-10-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
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doi：
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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pub_type： 杂志文章,meta分析,评审
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更新日期：2010-09-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2014-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
