Abstract：
BACKGROUND:Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, so it was expected that posttraumatic stress disorder (PTSD) would be associated with activation of this axis; however, studies have found both increased and decreased cortisol in PTSD. To address this question, we collected saliva cortisol at home in a subsample of a longitudinal epidemiologic sample. METHODS:Six hundred eighty-four persons randomly selected from the total sample of 913 were requested to collect saliva samples upon awakening and in the early evening. Of these, 538 responded with samples, 516 of whom met inclusion criteria. These were 68 exposed to trauma with lifetime PTSD, 265 exposed to trauma with no PTSD, and 183 never exposed to trauma. RESULTS:In a comparison of these three groups, lifetime PTSD revealed elevated evening saliva cortisol compared with exposed/no PTSD. When lifetime comorbidity with major depressive disorder (MDD) was included in the analysis, only persons with comorbid PTSD and MDD showed this evening elevation in cortisol. Persons with PTSD alone (never MDD) showed normal saliva cortisol levels, as did subjects with lifetime MDD alone. CONCLUSIONS:Neither exposure to trauma nor PTSD alone is associated with alterations in saliva cortisol; however, elevated cortisol is found in PTSD comorbid with lifetime MDD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Young EA,Breslau Ndoi
10.1016/j.biopsych.2004.05.011subject
Has Abstractpub_date
2004-08-01 00:00:00pages
205-9issue
3eissn
0006-3223issn
1873-2402pii
S0006322304005621journal_volume
56pub_type
杂志文章abstract：BACKGROUND:Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrat...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.07.008
更新日期：2017-01-15 00:00:00
abstract：BACKGROUND:Proton magnetic resonance spectroscopy was used to determine the effects of intravenous cocaine or placebo administration on human basal ganglia water and metabolite resonances. METHODS:Long echo time, proton magnetic resonance spectra of water and intracellular metabolites were continuously acquired from a...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(00)00897-0
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Bipolar disorder is associated with functional and structural abnormalities in the brain circuits involved in processing emotional stimuli. Although impairments of cognitive function have been found to persist in bipolar patients during periods of euthymic mood, it is not known whether abnormalities in emoti...
journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2002-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2016.04.003
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder characterized by deficits in attention, increased motor impulsivity, and hyperactivity. Preliminary work in mice and humans has suggested the X-linked gene STS (which encodes the enzyme steroid sulfatase) as a mediator o...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.01.001
更新日期：2009-08-15 00:00:00
abstract：BACKGROUND:Suvorexant is an orexin receptor antagonist for treatment of insomnia. We report results from two pivotal phase 3 trials. METHODS:Two randomized, double-blind, placebo-controlled, parallel-group, 3-month trials in nonelderly (18-64 years) and elderly (≥65 years) patients with insomnia. Suvorexant doses of 4...
journal_title：Biological psychiatry
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2016-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(97)00355-7
更新日期：1998-05-01 00:00:00
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journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2014-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2019-01-15 00:00:00
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doi：10.1016/0006-3223(92)90309-n
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.03.007
更新日期：2012-08-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-12-15 00:00:00
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pub_type： 杂志文章
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更新日期：1996-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.04.023
更新日期：2007-10-15 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2001-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
