Abstract:
BACKGROUND:Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the amygdala, and hippocampus. Although the contributions of the medial PFC, amygdala, and hippocampus to fear and anxiety have been studied extensively with animal models, the selective roles of the ventral PFC-including the ventrolateral prefrontal cortex (vlPFC) and orbitofrontal cortex-are poorly understood. METHODS:We investigated the effects of selective excitotoxic lesions of either the vlPFC or anterior orbitofrontal cortex (antOFC) on anxious behavior and Pavlovian conditioned autonomic and behavioral fear responses in the New World primate, the common marmoset. RESULTS:Both vlPFC and antOFC lesions resulted in stronger, less adaptable conditioned fear responses. They also heightened the anxiety responses of a marmoset to a human intruder. In contrast, only a lesion of the vlPFC affected the coping style that a marmoset displayed in the presence of the human intruder, increasing the likelihood of proactive mobbing. CONCLUSIONS:These results suggest that both the antOFC and vlPFC can downregulate fear and anxiety and, together, provide necessary but independent contributions to the top-down control of negative emotion.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Agustín-Pavón C,Braesicke K,Shiba Y,Santangelo AM,Mikheenko Y,Cockroft G,Asma F,Clarke H,Man MS,Roberts ACdoi
10.1016/j.biopsych.2012.03.007subject
Has Abstractpub_date
2012-08-15 00:00:00pages
266-72issue
4eissn
0006-3223issn
1873-2402pii
S0006-3223(12)00225-9journal_volume
72pub_type
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