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Proton magnetic resonance spectroscopy of basal ganglia in chronic schizophrenia.

Abstract：

:Proton spectra in the regions of the right and left basal ganglia were studied in 14 medicated patients with chronic schizophrenia using proton magnetic resonance spectroscopy (1H MRS). Ratios of N-acetyl-aspartate (NAA) to choline-containing compounds (Cho) were significantly reduced in the bilateral basal ganglia regions compared to normal subjects. The relative level of Cho was increased in the left basal ganglia region in comparison to normal subjects. This finding suggests the presence of disturbances in phospholipid metabolism in the basal ganglia. The level of NAA was decreased in the bilateral basal ganglia regions, which may indicate neuronal dysfunction. The 1H MRS study demonstrated dysfunctions in the basal ganglia regions in medicated patients with chronic schizophrenia.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Fujimoto T,Nakano T,Takano T,Takeuchi K,Yamada K,Fukuzako T,Akimoto H

doi

10.1016/0006-3223(95)00316-9

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

14-8

issue

1

eissn

0006-3223

issn

1873-2402

pii

0006-3223(95)00316-9

journal_volume

40

pub_type

杂志文章

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