Peripheral thyroid hormone levels in treatment resistant depression.

abstract：BACKGROUND:Mismatch negativity (MMN) is a negative-going event-related potential (ERP) component that occurs in response to intermittent changes in constant auditory backgrounds. A consistent finding across a large number of studies has been impaired MMN generation in schizophrenia, which has been interpreted as eviden...

journal_title：Biological psychiatry

authors： Magno E,Yeap S,Thakore JH,Garavan H,De Sanctis P,Foxe JJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Deletions encompassing a four-gene region on chromosome 15 (BP1-BP2 at 15q11.2), seen at a population frequency of 1 in 500, are associated with increased risk for schizophrenia, epilepsy, and other common neurodevelopmental disorders. However, little is known in terms of how these common deletions impact co...

journal_title：Biological psychiatry

authors： Woo YJ,Kanellopoulos AK,Hemati P,Kirschen J,Nebel RA,Wang T,Bagni C,Abrahams BS

更新日期：2019-08-15 00:00:00

abstract：BACKGROUND:Impaired neuromotor development is often one of the earliest observations in children with autism spectrum disorder (ASD). We investigated whether a genetic predisposition to developmental disorders was associated with nonoptimal neuromotor development during infancy and examined the genetic correlation betw...

journal_title：Biological psychiatry

authors： Serdarevic F,Tiemeier H,Jansen PR,Alemany S,Xerxa Y,Neumann A,Robinson E,Hillegers MHJ,Verhulst FC,Ghassabian A

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND:The aim of this study was to extend our previous work on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in major depression to patients with schizophrenia. METHODS:Thirty-five inpatients with schizophrenia were randomly assigned to either right prefrontal rTMS or sham treatm...

journal_title：Biological psychiatry

authors： Klein E,Kolsky Y,Puyerovsky M,Koren D,Chistyakov A,Feinsod M

更新日期：1999-11-15 00:00:00

abstract：BACKGROUND:Previous studies have shown that cocaine abusers have cerebral perfusion deficits that may diminish cognitive functioning. This study examined whether cocaine-dependent patients have perfusion abnormalities associated with poor decision-making ability as measured by the Iowa Gambling Task (IGT). METHODS:Sev...

journal_title：Biological psychiatry

authors： Tucker KA,Potenza MN,Beauvais JE,Browndyke JN,Gottschalk PC,Kosten TR

更新日期：2004-10-01 00:00:00

abstract：:The smooth pursuit responses to 5 degrees and 20 degrees/sec constant-velocity stimuli were recorded from 23 patients with schizophrenia, 16 affective disorder patients, and 21 normals using low-noise infrared oculography. Pursuit gain, catch-up saccade (CUS) rate and amplitude, and their interrelationships were exami...

journal_title：Biological psychiatry

authors： Abel LA,Friedman L,Jesberger J,Malki A,Meltzer HY

更新日期：1991-06-01 00:00:00

abstract：:In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...

journal_title：Biological psychiatry

authors： Lauer CJ,Riemann D,Wiegand M,Berger M

更新日期：1991-05-15 00:00:00

abstract：BACKGROUND:Plasma homovanillic acid (HVA) changes in response to a challenge of several days with haloperidol have been found to be predictive of the therapeutic response to haloperidol over a longer period of treatment. METHODS:Twenty-six elderly women who gave informed consent were divided into two groups, with or w...

journal_title：Biological psychiatry

authors： Andia I,Zumarraga M,Zabalo MJ,Bulbena A,Davila R

更新日期：1998-01-01 00:00:00

abstract：:Pre-treatment and posttreatment dexamethasone suppression test (DST) results in physically healthy elderly major depressives without dementia demonstrated an association between treatment and DST normalization. Sixty percent of subjects were nonsuppressors at baseline compared to 17% after intensive treatment. DST res...

journal_title：Biological psychiatry

authors： Meyers BS,Alpert S,Gabriele M,Kakuma T,Kalayam B,Alexopoulos GS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Working memory impairments are commonly found in attention-deficit/hyperactivity disorder (ADHD) and often improve with psychostimulant treatment. Little is known about how these medications affect the function of frontoparietal brain regions engaged for working memory. This study used functional magnetic re...

journal_title：Biological psychiatry

authors： Wong CG,Stevens MC

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Recent findings indicate that inhibitors of fatty acid amide hydrolase (FAAH) counteract the rewarding effects of nicotine in rats. Inhibition of FAAH increases levels of several endogenous substances in the brain, including the endocannabinoid anandamide and the noncannabinoid fatty acid ethanolamides oleoy...

journal_title：Biological psychiatry

authors： Mascia P,Pistis M,Justinova Z,Panlilio LV,Luchicchi A,Lecca S,Scherma M,Fratta W,Fadda P,Barnes C,Redhi GH,Yasar S,Le Foll B,Tanda G,Piomelli D,Goldberg SR

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The goal of this study was to identify chromosomal regions likely to contain susceptibility loci for obsessive-compulsive disorder (OCD). METHODS:We conducted a genome-wide linkage scan, with average marker spacing less than 10 centimorgans (cM), in 121 subjects from 26 families ascertained through probands...

journal_title：Biological psychiatry

authors： Hanna GL,Veenstra-Vanderweele J,Cox NJ,Van Etten M,Fischer DJ,Himle JA,Bivens NC,Wu X,Roe CA,Hennessy KA,Dickel DE,Leventhal BL,Cook EH Jr

更新日期：2007-10-15 00:00:00

abstract：:Unlike disorders of other fields of medicine (eg., diabetes, heart disease), schizophrenia has been only marginally impacted by the study of animal models. This gap reflects the incomplete understanding of the causes and mechanisms of schizophrenia and the resulting lack of defined targets for model development. Howev...

journal_title：Biological psychiatry

authors： Kilts CD

更新日期：2001-12-01 00:00:00

abstract：:Auditory evoked potentials were recorded using a paired click, conditioning-testing paradigm in 10 schizophrenics and in 10 normal subjects with no family history of psychotic disorder. The paradigm is used to demonstrate central nervous system gating of responsiveness to auditory stimuli by examining the extent to wh...

journal_title：Biological psychiatry

authors： Nagamoto HT,Adler LE,Waldo MC,Freedman R

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Metyrapone blocks cortisol synthesis which results in removal of negative feedback, a stimulation of hypothalamic corticotropin releasing factor (CRF) and a reduction in delta sleep. We previously reported a diminished delta sleep and hypothalamic-pituitary-adrenal (HPA) response to metyrapone in men with po...

journal_title：Biological psychiatry

authors： Otte C,Lenoci M,Metzler T,Yehuda R,Marmar CR,Neylan TC

更新日期：2007-04-15 00:00:00

abstract：BACKGROUND:This pilot study was designed to evaluate ABT-089, a neuronal nicotinic receptor partial agonist, as treatment for adult attention-deficit/hyperactivity disorder (ADHD). METHODS:Adults with ADHD received placebo, 2 mg, 4 mg, or 20 mg of ABT-089 for 2 weeks each in a randomized, double-blind, placebo-control...

journal_title：Biological psychiatry

authors： Wilens TE,Verlinden MH,Adler LA,Wozniak PJ,West SA

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN). METHODS:To assess possibly trait-related disturbances but avoid confounding effects of malnutrition, 10 women...

journal_title：Biological psychiatry

authors： Frank GK,Bailer UF,Henry SE,Drevets W,Meltzer CC,Price JC,Mathis CA,Wagner A,Hoge J,Ziolko S,Barbarich-Marsteller N,Weissfeld L,Kaye WH

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Although cocaine is known to be a highly addictive drug, there appears to be a select subset of individuals who are able to use the substance recreationally without developing dependence. These individuals do not report experiencing feelings of craving for cocaine, an important distinction from dependent use...

journal_title：Biological psychiatry

authors： Smith DG,Simon Jones P,Bullmore ET,Robbins TW,Ersche KD

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:Several studies have found that alpha-tocopherol (vitamin E) can effectively treat tardive dyskinesia (TD). A limitation of these trials is their short treatment durations (maximum of 12 weeks), which do not allow us to address the effects of long-term treatment. METHODS:To participate, patients had to have...

journal_title：Biological psychiatry

authors： Adler LA,Edson R,Lavori P,Peselow E,Duncan E,Rosenthal M,Rotrosen J

更新日期：1998-06-15 00:00:00

abstract：:Magnetic resonance spectroscopy allows investigation of in vivo neurochemical pathology of schizophrenia. "First generation" studies, focusing on phosphorus and proton magnetic resonance spectroscopy, have suggested alterations in membrane phospholipid metabolism and reductions in N-acetyl aspartate in the frontal and...

journal_title：Biological psychiatry

authors： Keshavan MS,Stanley JA,Pettegrew JW

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability, and predictors of mood and anxiety diso...

journal_title：Biological psychiatry

authors： Roberts JE,Tonnsen BL,McCary LM,Ford AL,Golden RN,Bailey DB Jr

更新日期：2016-05-15 00:00:00

abstract：BACKGROUND:Panic is characterized as a disorder of interoceptive physiologic hyperarousal, secondary to persistent anticipation of panic attacks. The novel aim of this research was to investigate whether severity of agoraphobia within panic disorder covaries with the intensity of physiological reactions to imagery of p...

journal_title：Biological psychiatry

authors： McTeague LM,Lang PJ,Laplante MC,Bradley MM

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Recent studies raise questions on the relationship between adolescent fears and risk for major depression. METHODS:An epidemiologic sample of 776 young people received psychiatric assessments in 1983, 1985-1986, and 1992. Prospective associations were examined between fears in adolescence and future episode...

journal_title：Biological psychiatry

authors： Pine DS,Cohen P,Brook J

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Previous work has implicated noradrenergic beta-receptors in the consolidation and reconsolidation of conditioned fear. Less is known, however, about their role in fear expression and extinction. The beta-receptor blocker propranolol has been used clinically to reduce anxiety. With an auditory fear condition...

journal_title：Biological psychiatry

authors： Rodriguez-Romaguera J,Sotres-Bayon F,Mueller D,Quirk GJ

更新日期：2009-05-15 00:00:00

abstract：:Acute Intermittent Porphyria (AIP) is an autosomal dominant metabolic disorder that has various psychiatric manifestations. This is a report of a case who had six brief psychotic episodes of varying nature within a 2-month period. The psychotic manifestations included catatonic stupor, hypomania, and delirium in diffe...

journal_title：Biological psychiatry

authors： Santosh PJ,Malhotra S

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures. METHODS:We used...

journal_title：Biological psychiatry

authors： Bearden CE,Thompson PM,Dalwani M,Hayashi KM,Lee AD,Nicoletti M,Trakhtenbroit M,Glahn DC,Brambilla P,Sassi RB,Mallinger AG,Frank E,Kupfer DJ,Soares JC

更新日期：2007-07-01 00:00:00

abstract：:The role of developmental theory and developmental psychopathology in understanding the development, maintenance, and course of social anxiety disorder (SAD) is explored in this article. Following a brief examination of the phenomenology of SAD in youth, we provide an overview of the tenets of developmental psychology...

journal_title：Biological psychiatry

authors： Ollendick TH,Hirshfeld-Becker DR

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Head growth rates are often accelerated in autism. This study is aimed at defining the clinical, morphological, and biochemical correlates of head circumference in autistic patients. METHODS:Fronto-occipital head circumference was measured in 241 nonsyndromic autistic patients, 3 to 16 years old, diagnosed ...

journal_title：Biological psychiatry

authors： Sacco R,Militerni R,Frolli A,Bravaccio C,Gritti A,Elia M,Curatolo P,Manzi B,Trillo S,Lenti C,Saccani M,Schneider C,Melmed R,Reichelt KL,Pascucci T,Puglisi-Allegra S,Persico AM

更新日期：2007-11-01 00:00:00

abstract：:Accumulating evidence supports the view that deregulation of the immune system represents an important vulnerability factor for psychosis. In a subgroup of psychotic patients, the high comorbidity with autoimmune and chronic inflammatory conditions suggests a common underlying immune abnormality leading to both condit...

journal_title：Biological psychiatry

authors： Bergink V,Gibney SM,Drexhage HA

更新日期：2014-02-15 00:00:00

abstract：:Postmortem volumetry of cortex, white matter, and basal ganglia was performed in 23 brains of schizophrenic patients and 23 brains of controls closely matched for gender, age, and hemisphere. Stereological methods were applied to serial coronal sections of complete hemispheres. We found no significant volume changes o...

journal_title：Biological psychiatry

authors： Heckers S,Heinsen H,Heinsen Y,Beckmann H

更新日期：1991-03-15 00:00:00