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Right prefrontal slow repetitive transcranial magnetic stimulation in schizophrenia: a double-blind sham-controlled pilot study.

Abstract：

BACKGROUND:The aim of this study was to extend our previous work on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in major depression to patients with schizophrenia. METHODS:Thirty-five inpatients with schizophrenia were randomly assigned to either right prefrontal rTMS or sham treatment and were rated before and after treatment for positive, negative, and depressive symptoms. RESULTS:Thirty-one subjects (rTMS = 16, sham = 15) completed a 2-week treatment protocol. No serious adverse effects were reported; however, rTMS was not superior to sham treatment on any of the clinical ratings. CONCLUSIONS:In contrast to our previous positive findings in major depression, right prefrontal slow rTMS does not appear to have a beneficial effect for actively psychotic patients with schizophrenia.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Klein E,Kolsky Y,Puyerovsky M,Koren D,Chistyakov A,Feinsod M

doi

10.1016/s0006-3223(99)00182-1

subject

Has Abstract

pub_date

1999-11-15 00:00:00

pages

1451-4

issue

10

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(99)00182-1

journal_volume

46

pub_type

临床试验,杂志文章,随机对照试验

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