Abstract:
:Platelet MAO activity in schizophrenics was significantly decreased, by about 15%, after 3 weeks of treatment with haloperidol. Treatment with thioridazine or butaperazine also tended to decrease platelet MAO activity. The neuroleptic-induced decrease began to appear within a few days of treatment and did not show tolerance over 1-2 months of treatment with haloperidol. Platelet MAO activity of schizophrenic patients measured during drug-free base-line was not significantly different from that of normal controls, but MAO activity of schizophrenics was significantly lower than normals after 3 weeks of treatment with neuroleptics. The extent of decrease in platelet MAO activity correlated negatively with base-line prolactin and its increase after 24 hr. With PEA as substrate, the decrease in activity correlated positively with steady state plasma haloperidol.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Ho BT,Smith RC,Kralik P,Allen R,Schoolar J,Khan M,DeJohn Csubject
Has Abstractpub_date
1982-08-01 00:00:00pages
885-95issue
8eissn
0006-3223issn
1873-2402journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Cortical glutamate levels are elevated in bipolar disorder, but the interpretation of this increase is unclear because glutamate has metabolic as well as neurotransmitter roles. We investigated this by measuring vesicular glutamate transporter 1 (VGluT1) expression, which reflects activity at glutamate synap...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.12.004
更新日期:2010-06-01 00:00:00
abstract::The present study was undertaken in order to further explore the relationship between monoamine levels and hypothalamic-pituitary-adrenocortical (HYPAC) functioning and suicidal behavior in depressed patients. One hundred and thirty-two depressed inpatients participated in the NIMH Collaborative Study on the Psychobio...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(86)90241-6
更新日期:1986-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0304-3959(84)90863-7
更新日期:1984-02-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:1990-01-15 00:00:00
abstract:BACKGROUND:Marked interindividual differences in vulnerability to nicotine dependence exist, but factors underlying such differences are not well understood. The midbrain alpha4beta2* subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediation of the reinforcing effects of nicotine responsibl...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.09.036
更新日期:2009-04-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
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更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Current smoking cessation therapies offer limited success, as relapse rates remain high. Nicotine, which is the major component of tobacco smoke, is thought to be primarily responsible for the addictive properties of tobacco. However, little is known about the molecular mechanisms underlying nicotine relapse...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2014.02.001
更新日期:2014-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.05.032
更新日期:2009-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.03.061
更新日期:2006-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.01.002
更新日期:2010-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Striatal enlargement with chronic neuroleptic treatment in schizophrenic patients has been reported by several investigators. Longitudinal magnetic resonance imaging studies of patients suggest that changes in striatal volume may be caused by treatment with antipsychotic medication. METHODS:We have examined...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00029-8
更新日期:1998-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(88)90254-5
更新日期:1988-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract::The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90143-n
更新日期:1992-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(02)01490-7
更新日期:2003-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2019.08.028
更新日期:2020-01-01 00:00:00
abstract::To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for ...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(03)00171-9
更新日期:2003-09-01 00:00:00
abstract::Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some conditions are defined by the presence of impairments in social interaction or maintaining interpersonal relationships;...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2012.03.033
更新日期:2012-07-15 00:00:00
abstract::The effects of changes in pCO2 in the development and resolution of normal (return to base line within 2 sec after S2) and abnormal (return to base line in more than 2 sec after S2) CNVs were studied. Decreased pCO2 produced by hyperventilation induced a significant reduction in the duration of the post-imperative neg...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND:Pediatric Bipolar Disorder (BD) has been associated with a number of neurocognitive deficits not dissimilar to ADHD. This study compared neuropsychological profiles of 4 groups of adolescents (14-17 years): 41 Normal Controls (NC), 30 ADHD, 12 BD and 12 combined (BD+ADHD). METHODS:Participants were identifi...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.03.067
更新日期:2006-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.06.036
更新日期:2007-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0006-3223(95)00224-3
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Although cocaine is known to be a highly addictive drug, there appears to be a select subset of individuals who are able to use the substance recreationally without developing dependence. These individuals do not report experiencing feelings of craving for cocaine, an important distinction from dependent use...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.05.019
更新日期:2014-01-15 00:00:00
abstract::This study examined the relationship between borderline and impulsive personality traits on the one hand, and monoamine function on the other in 15 women with bulimia nervosa and 15 women with recurrent suicidal behavior. Platelet serotonin (5-HT) and platelet monoamine oxidase (MAO) activity were used as peripheral m...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00384-3
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:The cardiovascular safety of mixed amphetamine salts extended release (MAS XR) was evaluated in 2968 children 6-12 years of age with attention-deficit/hyperactivity disorder (ADHD). METHODS:In this prospective, open-label, noncomparative, community-based study, subjects whose symptoms of ADHD were well cont...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.05.002
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Anxiety disorders are associated with disruptions in both emotional processing and decision making. As a result, anxious individuals often make decisions that favor harm avoidance. However, this bias could be driven by enhanced aversion to uncertainty about the decision outcome (e.g., risk) or aversion to ne...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2016.12.010
更新日期:2017-06-15 00:00:00
abstract:BACKGROUND:The current effective treatment options for posttraumatic stress disorder (PTSD) are limited, and therefore the need to explore new treatment strategies is critical. Pharmacological inhibition of the renin-angiotensin system is a common approach to treat hypertension, and emerging evidence highlights the imp...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.08.024
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined. METHODS:Postmortem samples from the orbitofrontal cortex (ORB) were colle...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.04.013
更新日期:2005-08-15 00:00:00
abstract:BACKGROUND:Hypersecretion of corticotropin-releasing hormone (CRH) in the brain has been implicated in stress-related human pathologies. We developed a transgenic mouse line overexpressing CRH (CRH-OE) exclusively in neural tissues to assess the effect of long-term CRH overproduction on regulation of the hypothalamic-p...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(02)01334-3
更新日期:2002-06-01 00:00:00