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Failure of glucose infusion to suppress the exaggerated GH response to GHRH in patients with anorexia nervosa.

Abstract：

:The growth hormone (GH) response to GH-releasing hormone (GHRH) is characteristically exaggerated in anorexia nervosa (AN). Hyperglycemia suppresses the GH response to GHRH in normal subjects. To test whether this inhibitory action of hyperglycemia is preserved in AN, we performed a GHRH (GHRH 1-40, 1 micrograms/kg) test under basal conditions (saline infusion) and during steady-state hyperglycemia (200 mg/dl, induced by the intravenous administration of 8 mg/min.kg of glucose) in 6 adolescent girls with acute-stage AN (as diagnosed by psychopathological, hormonal, and nutritional criteria) and in 5 age-matched female controls. In control subjects, GHRH stimulated GH release during saline, but not glucose, infusion. In the anorectic patients, the GH response to GHRH was exaggerated during both saline infusion (2.97 +/- 0.79 versus 0.52 +/- 0.22 micrograms.120 min.ml-1, p less than 0.02) and under hyperglycemic conditions (4.61 +/- 0.56 versus 0.33 +/- 0.10, p less than 0.001). We conclude that the inhibitory action of hyperglycemia on GHRH-induced GH release is lost in the acute phase of AN.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Rolla M,Andreoni A,Belliti D,Ferdeghini M,Ferrannini E

doi

10.1016/0006-3223(90)90651-h

subject

Has Abstract

pub_date

1990-01-15 00:00:00

pages

215-22

issue

2

eissn

0006-3223

issn

1873-2402

pii

0006-3223(90)90651-H

journal_volume

27

pub_type

杂志文章

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