Abstract:
BACKGROUND:Pediatric Bipolar Disorder (BD) has been associated with a number of neurocognitive deficits not dissimilar to ADHD. This study compared neuropsychological profiles of 4 groups of adolescents (14-17 years): 41 Normal Controls (NC), 30 ADHD, 12 BD and 12 combined (BD+ADHD). METHODS:Participants were identified according to a standardized protocol (WASHU-KSADS mood section, K-SADS-PL and Conners Scales) and completed tests of processing speed, memory, executive functioning, set shifting, and inhibition. ADHD adolescents on stimulant medication did not take it on the day. RESULTS:After controlling for covariates, the ADHD-only and combined groups were most impaired, including processing and naming speed, working memory, and response inhibition. The ADHD-only group showed specific impairment in naming objects, numbers and letters than the NC and showed greater deficits than the BD-only group on tests of naming speed. The combined group showed greatest deficits in verbal memory and inhibitory control. Other than working memory, there were no differences between the BD-only and NC groups. Removal of BD-NOS did not impact on the results. CONCLUSIONS:This study failed to find broad neurocognitive deficits in BD-only adolescents. Only those with comorbid ADHD showed cognitive deficits, highlighting the impact ADHD may have on neurocognitive functioning of BD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Rucklidge JJdoi
10.1016/j.biopsych.2006.03.067subject
Has Abstractpub_date
2006-11-01 00:00:00pages
921-8issue
9eissn
0006-3223issn
1873-2402pii
S0006-3223(06)00551-8journal_volume
60pub_type
杂志文章abstract:BACKGROUND:Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS:We used a recently...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.06.009
更新日期:2016-03-15 00:00:00
abstract:BACKGROUND:Patients with autism have been often reported to have a smaller corpus callosum (CC) than control subjects. METHODS:We conducted a meta-analysis of the literature, analyzed the CC in 694 subjects of the Autism Brain Imaging Data Exchange project, and performed computer simulations to study the effect of dif...
journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析
doi:10.1016/j.biopsych.2015.02.010
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Affective disorders are associated with prominent psychomotor abnormalities that may be related to changes in arousal or motivation due to altered catecholamine function. METHODS:We investigated relationships between performance on psychomotor tests of motor speed (reaction time and tapping speed) and visua...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00172-3
更新日期:1999-04-15 00:00:00
abstract::Previous studies have suggested that tardive dyskinesia may occur more frequently in patients who smoke. Further evidence of an interaction between smoking and movement disorders includes the low lifetime exposure to cigarettes found in Parkinson's disease patients. In this study 126 patients with chronic psychiatric ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90163-g
更新日期:1991-07-15 00:00:00
abstract:BACKGROUND:The stomach-derived hormone ghrelin drives higher-order feeding processes related to food reward and food seeking via central nervous system signaling at its receptor (GHSR1A). The specific nuclei mediating these effects are only partially understood. Here, we use a rat model to examine whether ghrelin signa...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.07.002
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Abnormal sensory gating in schizophrenia has frequently been reported; however, only limited data on unmedicated patients and patients at risk to develop a psychosis have, as yet, been available. METHODS:P50 and N100 suppression were assessed with an auditory double-click paradigm in five groups: 18 at-risk...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.02.006
更新日期:2008-09-01 00:00:00
abstract::The effect of nortriptyline was assessed on the EEG sleep of 20 inpatients with major depressive syndrome. While 25 mg of nortriptyline had an immediate effect on REM sleep variables, relatively little influence on sleep continuity measures was noted. Subsequent administration of 75 and 100 mg of nortriptyline produce...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(98)00287-x
更新日期:1999-01-01 00:00:00
abstract::The interaction between various neuroleptics and antiparkinsonian drugs was analyzed by measuring the neuroleptic plasma level before and after withdrawal of antiparkinsonian drugs. The population completing the study consisted of 32 chronic schizophrenics treated with chlorpromazine (8), levomepromazine (14), thiorid...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90079-f
更新日期:1992-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00390-8
更新日期:1996-08-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.02.017
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:There is a need for improved treatments for ethanol withdrawal in humans. Previously, ethanol withdrawal has been shown to enhance the acoustic startle response in rats. Because many ethanol withdrawal symptoms are caused by autonomic hyperactivity, we examined the effects of two antihypertensives, the imida...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(00)00229-8
更新日期:2000-05-15 00:00:00
abstract::We examined the circadian rhythm of core body temperature (CBT) in 22 school refusal patients, ages between 12 and 18 years, who did not have any physical or psychiatric disorders, but had indefinite complaints, and were suspected to have a circadian rhythm disturbance. To obtain normal data for analysis, CBT in 9 hea...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/S0006-3223(96)00179-5
更新日期:1997-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析
doi:10.1016/j.biopsych.2006.08.025
更新日期:2007-04-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2017.12.010
更新日期:2018-07-15 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) in the adolescent demonstrates a unique clinical profile, and pathogenic serotonergic dysregulation is hypothesized. Parenteral clomipramine (CMI) is known to distinguish adult MDD from control, but neurochallenge data are lacking in adolescent MDD. METHODS:Thirteen drug-free...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/s0006-3223(97)00447-2
更新日期:1998-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.04.006
更新日期:2012-09-01 00:00:00
abstract::The total number of neurons was estimated in eight brains from chronic schizophrenic men and compared with 16 gender- and age-matched controls. The average total neocortical nerve cell number was 22.12.10(9) in schizophrenics and 22.06.10(9) in controls. The estimate of total cell numbers can not demonstrate more subt...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(93)90065-l
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Affective facial processing is an important component of interpersonal relationships. The neural substrate has been examined following treatment with antidepressant medication but not with psychological therapies. The present study investigated the neural correlates of implicit processing of sad facial expre...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.04.033
更新日期:2008-09-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90073-u
更新日期:1991-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00063-1
更新日期:1995-12-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Postmortem studies examining discrete regions show reduced cortical thickness in schizophrenia. Computational image analysis methods allow spatially detailed cortical thickness measurements across the entire cortex in 3D, but have not addressed thickness changes in cingulate or other cortices bordering the m...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.03.043
更新日期:2005-07-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.12.032
更新日期:2010-06-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.10.003
更新日期:2013-02-15 00:00:00
abstract::Natural lithium (Li) salts, including those used routinely in manic depressive illness, consist of two stable nonradioactive isotopes: lithium-7 (Li-7) (92.6%) and lithium-6 (Li-6) (7.4%). Female rats (3 months old) were treated with either Li-7 chloride or Li-6 chloride or were untreated prior to and during gestation...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(86)90308-2
更新日期:1986-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01074-5
更新日期:2001-10-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2009.05.027
更新日期:2009-11-15 00:00:00