Urinary tryptamine excretion in chronic schizophrenics with low platelet MAO activity.

abstract：BACKGROUND:Recent postmortem studies demonstrate disrupted neurochemistry of the noradrenergic locus coeruleus (LC) in major depression (MD). Increased levels of tyrosine hydroxylase and decreased levels of norepinephrine transporter implicate a norepinephrine deficiency in the LC in MD. Here we describe a study of alp...

journal_title：Biological psychiatry

authors： Ordway GA,Schenk J,Stockmeier CA,May W,Klimek V

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have ...

journal_title：Biological psychiatry

authors： Gotlib IH,Joormann J,Minor KL,Hallmayer J

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Recently, it has been reported that serum interleukin-1 beta (IL-1 beta), but not soluble IL-2 receptor (sIL-2R), concentrations were significantly higher in patients with posttraumatic stress disorder (PTSD) than in normal volunteers, and that psychological stress in humans is associated with increased secr...

journal_title：Biological psychiatry

authors： Maes M,Lin AH,Delmeire L,Van Gastel A,Kenis G,De Jongh R,Bosmans E

更新日期：1999-04-01 00:00:00

abstract：:[3H]imipramine binding to platelets was measured in 17 drug-free panic disorder patients and 14 healthy controls. No difference in Bmax or Kd values was found between the two groups. Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder pati...

journal_title：Biological psychiatry

authors： Uhde TW,Berrettini WH,Roy-Byrne PP,Boulenger JP,Post RM

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Schizophrenia patients exhibit impairment in prepulse inhibition (PPI) of the acoustic startle response (ASR), suggesting a sensorimotor gating deficit. The serotonin-2A receptor (5-HT(2A)R) has been implicated in both the pathogenesis of schizophrenia and the PPI deficits of schizophrenia patients. Moreover...

journal_title：Biological psychiatry

authors： Quednow BB,Kühn KU,Mössner R,Schwab SG,Schuhmacher A,Maier W,Wagner M

更新日期：2008-09-01 00:00:00

abstract：:Despite the proven efficacy of acetylcholinesterase inhibitors in Alzheimer's disease, there is a need for new and more effective treatments. Galantamine is a novel treatment for Alzheimer's disease that inhibits acetylcholinesterase and modulates nicotinic receptors. In randomized, double-blind, placebo-controlled st...

journal_title：Biological psychiatry

authors： Coyle J,Kershaw P

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Elevated endogenous levels of corticosteroids cause neural dysfunction and loss, especially within the hippocampus, as well as cognitive impairment in hippocampus-mediated tasks. Because Cushing's syndrome patients suffer from hypercortisolism, they represent a unique opportunity to study the impact of eleva...

journal_title：Biological psychiatry

authors： Grillon C,Smith K,Haynos A,Nieman LK

更新日期：2004-12-01 00:00:00

abstract：:The author presents six cases of pseudodementia of varying degrees of severity that illustrate the difficulty in making purely clinical diagnoses of pseudodementia and demonstrate the usefulness of ECT in this condition in treatment-resistant patients. In addition, issues of cerebral laterality are raised by one case ...

journal_title：Biological psychiatry

authors： Allen RM

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Traditionally, norepinephrine has been associated with stress responses, whereas dopamine has been associated with reward. Both of these catecholamines are found within the bed nucleus of the stria terminalis (BNST), a brain relay nucleus in the extended amygdala between cortical/limbic centers, and the hypo...

journal_title：Biological psychiatry

authors： Park J,Wheeler RA,Fontillas K,Keithley RB,Carelli RM,Wightman RM

更新日期：2012-02-15 00:00:00

abstract：:The concentration of kynurenine, a neuroactive tryptophan metabolite, in blood plasma after pharmacologically induced anxiety was studied. Anxiety was provoked in 15 healthy volunteers by an anxiogenic dose of caffeine. Kynurenine concentration was markedly increased at the peak of anxiety and returned to normal after...

journal_title：Biological psychiatry

authors： Orlikov A,Ryzov I

更新日期：1991-02-15 00:00:00

abstract：BACKGROUND:Fragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period. ...

journal_title：Biological psychiatry

authors： Bray S,Hirt M,Jo B,Hall SS,Lightbody AA,Walter E,Chen K,Patnaik S,Reiss AL

更新日期：2011-11-01 00:00:00

abstract：:A group of 231 psychiatric patients were evaluated (with the Wechsler Adult Intelligence Scale and the Halstead-Reitan Neuropsychological Test Battery) before and after electroconvulsive therapy. Improvement during the course of therapy was shown in 96% of the measures and significant improvement (p less than 0.05) oc...

journal_title：Biological psychiatry

authors： Malloy FW,Small IF,Miller MJ,Milstein V,Stout JR

更新日期：1982-01-01 00:00:00

abstract：:The locus coeruleus (LC) is the major noradrenergic nucleus in the brain and innervates large segments of the neuraxis. LC neurons are thought to regulate states of attention and vigilance as well as activity of the sympathetic nervous system. These neurons also have been implicated in the actions of stress, antidepre...

journal_title：Biological psychiatry

authors： Nestler EJ,Alreja M,Aghajanian GK

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the amygdala, and hippocampus. Although the contributions of the media...

journal_title：Biological psychiatry

authors： Agustín-Pavón C,Braesicke K,Shiba Y,Santangelo AM,Mikheenko Y,Cockroft G,Asma F,Clarke H,Man MS,Roberts AC

更新日期：2012-08-15 00:00:00

abstract：BACKGROUND:The single most important risk factor for Alzheimer's pathology is age. Elderly individuals are also at increased risk for suicide, but comprehensive studies of the association between Alzheimer's pathology and suicide are lacking. We designed the current study to determine if Alzheimer's disease changes are...

journal_title：Biological psychiatry

authors： Rubio A,Vestner AL,Stewart JM,Forbes NT,Conwell Y,Cox C

更新日期：2001-01-15 00:00:00

abstract：:Using magnetic resonance imaging (MRI), we measured the volumes of various brain structures and cerebrospinal fluid (CSF) in 19 men with dementia of the Alzheimer type (DAT) and 18 healthy age-matched control men. The mean (+/- S.D) Mini-Mental State exam score (MMSE) of the DAT men was 16 +/- 7; 9 were mildly (MMSE >...

journal_title：Biological psychiatry

authors： Murphy DG,DeCarli CD,Daly E,Gillette JA,McIntosh AR,Haxby JV,Teichberg D,Schapiro MB,Rapoport SI,Horwitz B

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Major depressive disorder is associated with dysregulated basal cortisol levels and small hippocampal (HC) volume. However, it is still debated whether these phenomena are a consequence of the illness or whether they may represent a vulnerability marker existing before the illness onset. Here, we aimed to ex...

journal_title：Biological psychiatry

authors： Dedovic K,Engert V,Duchesne A,Lue SD,Andrews J,Efanov SI,Beaudry T,Pruessner JC

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Comparing prefrontal cortical activity during particular phases of working memory in healthy subjects and individuals diagnosed with schizophrenia might help to define the phase-specific deficits in cortical function that contribute to cognitive impairments associated with schizophrenia. This study featured ...

journal_title：Biological psychiatry

authors： Driesen NR,Leung HC,Calhoun VD,Constable RT,Gueorguieva R,Hoffman R,Skudlarski P,Goldman-Rakic PS,Krystal JH

更新日期：2008-12-15 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are potent regulators of gene expression with proposed roles in brain development and function. We hypothesized that miRNA expression profiles are altered in individuals with severe psychiatric disorders. METHODS:With real-time quantitative polymerase chain reaction, we compared the expre...

journal_title：Biological psychiatry

authors： Moreau MP,Bruse SE,David-Rus R,Buyske S,Brzustowicz LM

更新日期：2011-01-15 00:00:00

abstract：:A decreased secretion of arginine vasopressin (AVP) has been implicated in depression. In order to further investigate this hypothesis, we studied the plasma level of the specific peptidergic carrier of AVP, vasopressin neurophysin (hNpI), in 26 depressed inpatients and 16 matched normal controls. On the other hand, A...

journal_title：Biological psychiatry

authors： Laruelle M,Seghers A,Goffinet S,Bouchez S,Legros JJ

更新日期：1990-06-01 00:00:00

abstract：:The present study was undertaken to investigate if acute anxiety can affect plasma concentrations of homovanillic acid (pHVA). Since elevated pHVA levels have been associated with severity of schizophrenic symptoms, the results of this study will help determine if the pHVA elevations are directly related to psychosis ...

journal_title：Biological psychiatry

authors： Zemishlany Z,Davidson M

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:This study assessed whether reduced regional cerebral blood flow (rCBF; hypoperfusion) in cocaine-dependent (CD) patients is associated with platelet abnormalities and whether these platelet abnormalities predict improvement in hypoperfusion after 1 month of abstinence. METHODS:We correlated platelet number...

journal_title：Biological psychiatry

authors： Kosten TR,Tucker K,Gottschalk PC,Rinder CS,Rinder HM

更新日期：2004-01-01 00:00:00

abstract：:A cellular model for bipolar illness is presented. It is propounded that alterations in the activity of the membrane sodium- and potassium-activated adenosine triphosphatase pump (Na,K-ATPase) may be responsible for alterations in neuronal excitability and activity. Specifically, a reduction in Na,K-ATPase activity ca...

journal_title：Biological psychiatry

authors： el-Mallakh RS,Wyatt RJ

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Why do we jump the gun or speak out of turn? Waiting impulsivity has a preclinical basis as a predictor for the development of addiction. Here, we mapped the intrinsic neural correlates of waiting and dissociated it from stopping, both fundamental mechanisms of behavioral control. METHODS:We used a recently...

journal_title：Biological psychiatry

authors： Morris LS,Kundu P,Baek K,Irvine MA,Mechelmans DJ,Wood J,Harrison NA,Robbins TW,Bullmore ET,Voon V

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Women are overrepresented in samples of patients with rapid cycling bipolar disorder (RCBD). To explore whether menstrually related mood changes might account for this gender difference, we studied the relationship between menstrual cycle phase and mood in a sample of premenopausal women with rapid cycling b...

journal_title：Biological psychiatry

authors： Leibenluft E,Ashman SB,Feldman-Naim S,Yonkers KA

更新日期：1999-08-15 00:00:00

abstract：BACKGROUND:Neurobiologic abnormalities in the thalamus have been implicated in the pathophysiology of obsessive-compulsive disorder. We recently reported increased thalamic volume in treatment-naive pediatric obsessive-compulsive disorder patients versus case-matched healthy comparison subjects that decreased to levels...

journal_title：Biological psychiatry

authors： Rosenberg DR,Benazon NR,Gilbert A,Sullivan A,Moore GJ

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:The antidepressant-like effects of brain-derived neurotrophic factor (BDNF) infusions in brain, and the upregulation of BDNF mRNA and its receptor in rats exposed to electroconvulsive seizure (ECS) and antidepressants, suggested a role for increased BDNF protein. METHODS:We measured BDNF protein levels with...

journal_title：Biological psychiatry

authors： Altar CA,Whitehead RE,Chen R,Wörtwein G,Madsen TM

更新日期：2003-10-01 00:00:00

abstract：:The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...

journal_title：Biological psychiatry

authors： Zohar J,Bannet J,Drummer D,Fisch R,Epstein RP,Belmaker RH

更新日期：1983-05-01 00:00:00

abstract：:Proton spectra in the regions of the right and left basal ganglia were studied in 14 medicated patients with chronic schizophrenia using proton magnetic resonance spectroscopy (1H MRS). Ratios of N-acetyl-aspartate (NAA) to choline-containing compounds (Cho) were significantly reduced in the bilateral basal ganglia re...

journal_title：Biological psychiatry

authors： Fujimoto T,Nakano T,Takano T,Takeuchi K,Yamada K,Fukuzako T,Akimoto H

更新日期：1996-07-01 00:00:00

abstract：:The densities of platelet 3H-imipramine sites were determined by repetitive measures of 11 normal controls over the course of 1 year. A significant seasonal variation was found, with a circannual peak on February 17 and a nadir on August 18. The estimated amplitude of this rhythm was +/- 599.54 fmol/mg, which fluctuat...

journal_title：Biological psychiatry

authors： DeMet EM,Chicz-DeMet A,Fleischmann J

更新日期：1989-09-01 00:00:00