Abstract：
BACKGROUND:Recent evidence indicates that individuals who are homozygous for the short (s) allele in the promoter region of the serotonin transporter gene have higher rates of depression and other psychiatric disorders as a function of exposure to increasing levels of stressful life events than do individuals who have one or two copies of the long (l) allele. Despite the reliability of this association, the mechanism by which this polymorphism confers risk for psychopathology in the presence of stress is not understood. This study was designed to examine the formulation that individuals who are homozygous for the s allele are characterized by a greater biological reactivity to stress than are their counterparts who have one or two copies of the l allele. METHODS:Girls at high (n = 25) and low (n = 42) risk for depression by virtue of the presence or absence of a family history of this disorder were genotyped and exposed to a standardized laboratory stress task. Cortisol levels were assessed before the stressor, after the stressor, and during an extended recovery period. RESULTS:Girls who were homozygous for the s allele produced higher and more prolonged levels of cortisol in response to the stressor than did girls with an l allele. CONCLUSIONS:These findings indicate that the 5-HTTLPR polymorphism is associated with biological stress reactivity, which may increase susceptibility to depression in the face of stressful life events.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Gotlib IH,Joormann J,Minor KL,Hallmayer Jdoi
10.1016/j.biopsych.2007.10.008subject
Has Abstractpub_date
2008-05-01 00:00:00pages
847-51issue
9eissn
0006-3223issn
1873-2402pii
S0006-3223(07)00991-2journal_volume
63pub_type
杂志文章abstract：:The N400 component of event-related potentials (ERPs) was investigated in medicated schizophrenic patients and normal controls in a semantic categorization task. The subjects' task was to indicate whether pairs of words were semantically related or unrelated. The ERPs to the unrelated second words of the pairs contain...
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doi：10.1016/j.biopsych.2009.02.030
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pub_type： 临床试验,杂志文章
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更新日期：2005-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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更新日期：1998-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.06.001
更新日期：2004-08-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.02.008
更新日期：2010-06-15 00:00:00
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doi：10.1016/j.biopsych.2012.06.020
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：1995-02-15 00:00:00
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pub_type： 杂志文章
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更新日期：1989-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1994-03-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Cannabis remains the most widely used illicit substance by adolescents and is typically consumed by this population in the context of ongoing tobacco use. Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects o...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.02.014
更新日期：2007-01-01 00:00:00
