Synaptic adaptations in the nucleus accumbens caused by experiences linked to relapse.


BACKGROUND:Excitatory synaptic transmission in the nucleus accumbens (NAc) regulates the reinstatement of drug seeking, an animal model of relapse in human drug addicts. However, the functional adaptations at NAc synapses that mediate reinstatement are not clearly understood. METHODS:We assessed the behavioral responses of mice to cocaine administration by measuring locomotor stimulation and the acquisition, extinction, and reinstatement of conditioned place preference. Synaptic function was then examined by preparing acute brain slices and performing whole cell voltage-clamp recordings from individual medium spiny neurons in the NAc shell. RESULTS:We find that reduced excitatory synaptic strength in the NAc shell is a common functional adaptation induced by multiple experiences known to cause reinstatement, including stress and drug re-exposure. The same synaptic adaptation is observed shortly after reinstatement of conditioned place preference by a cocaine priming injection. CONCLUSIONS:This common synaptic modification associated with stress, drug re-exposure, and reinstatement defines a potential synaptic gateway to relapse.


Biol Psychiatry


Biological psychiatry


Rothwell PE,Kourrich S,Thomas MJ




Has Abstract


2011-06-01 00:00:00














  • Neural correlates of negative emotionality in borderline personality disorder: an activation-likelihood-estimation meta-analysis.

    abstract:BACKGROUND:Emotional vulnerabilities at the core of borderline personality disorder (BPD) involve a dysfunction of frontolimbic systems subserving negative emotionality. The specific regions identified in individual studies, however, vary widely and provide an incomplete understanding of the functional brain abnormalit...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,meta分析


    authors: Ruocco AC,Amirthavasagam S,Choi-Kain LW,McMain SF

    更新日期:2013-01-15 00:00:00

  • Volumetric magnetic resonance imaging in men with dementia of the Alzheimer type: correlations with disease severity.

    abstract::Using magnetic resonance imaging (MRI), we measured the volumes of various brain structures and cerebrospinal fluid (CSF) in 19 men with dementia of the Alzheimer type (DAT) and 18 healthy age-matched control men. The mean (+/- S.D) Mini-Mental State exam score (MMSE) of the DAT men was 16 +/- 7; 9 were mildly (MMSE >...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Murphy DG,DeCarli CD,Daly E,Gillette JA,McIntosh AR,Haxby JV,Teichberg D,Schapiro MB,Rapoport SI,Horwitz B

    更新日期:1993-11-01 00:00:00

  • A fenfluramine-activated FDG-PET study of borderline personality disorder.

    abstract:BACKGROUND:Impulsive aggression in patients with personality disorders is associated with diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to serotonergic agonists, and decreased glucose utilization in the prefrontal cortex. We tested the hypothesis that impulsive aggression in bo...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Soloff PH,Meltzer CC,Greer PJ,Constantine D,Kelly TM

    更新日期:2000-03-15 00:00:00

  • No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes.

    abstract:BACKGROUND:A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Johnson EC,Border R,Melroy-Greif WE,de Leeuw CA,Ehringer MA,Keller MC

    更新日期:2017-11-15 00:00:00

  • Reduced anterior cingulate glutamate in pediatric major depression: a magnetic resonance spectroscopy study.

    abstract:BACKGROUND:Anterior cingulate cortex has been implicated in the pathogenesis of major depressive disorder (MDD). With single voxel proton magnetic resonance spectroscopy, we reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in 14 pediatric MDD patients ver...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rosenberg DR,Macmaster FP,Mirza Y,Smith JM,Easter PC,Banerjee SP,Bhandari R,Boyd C,Lynch M,Rose M,Ivey J,Villafuerte RA,Moore GJ,Renshaw P

    更新日期:2005-11-01 00:00:00

  • Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified.

    abstract:BACKGROUND:Childhood-onset schizophrenia (COS), defined as onset of psychotic symptoms by age 12 years, is a rare and severe form of the disorder that seems to be clinically and neurobiologically continuous with the adult disorder. METHODS:We studied a rare cohort consisting of 98 probands; 71 of these probands receiv...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Addington AM,Gornick M,Sporn AL,Gogtay N,Greenstein D,Lenane M,Gochman P,Baker N,Balkissoon R,Vakkalanka RK,Weinberger DR,Straub RE,Rapoport JL

    更新日期:2004-05-15 00:00:00

  • Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

    abstract:BACKGROUND:Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the amygdala, and hippocampus. Although the contributions of the media...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Agustín-Pavón C,Braesicke K,Shiba Y,Santangelo AM,Mikheenko Y,Cockroft G,Asma F,Clarke H,Man MS,Roberts AC

    更新日期:2012-08-15 00:00:00

  • The serotonin transporter in the midbrain of suicide victims with major depression.

    abstract:BACKGROUND:The involvement of serotonin in depression and suicide has been proposed, because major depression is successfully treated by medications that specifically block the serotonin transporter, and there is evidence for a decrease in serotonin transporters in major depression and suicide. The midbrain dorsal raph...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Bligh-Glover W,Kolli TN,Shapiro-Kulnane L,Dilley GE,Friedman L,Balraj E,Rajkowska G,Stockmeier CA

    更新日期:2000-06-15 00:00:00

  • Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial.

    abstract:BACKGROUND:Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS:This 10-week, acute, randomized, controlled, masked trial compared adjunc...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rush AJ,Marangell LB,Sackeim HA,George MS,Brannan SK,Davis SM,Howland R,Kling MA,Rittberg BR,Burke WJ,Rapaport MH,Zajecka J,Nierenberg AA,Husain MM,Ginsberg D,Cooke RG

    更新日期:2005-09-01 00:00:00

  • Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers.

    abstract:BACKGROUND:There is evidence of abnormal cerebral dopamine transmission in nicotine-dependent smokers, but it is unclear whether dopaminergic abnormalities are due to acute nicotine abuse or whether they persist with abstinence. We addressed this question by conducting longitudinal positron emission tomography (PET) ex...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rademacher L,Prinz S,Winz O,Henkel K,Dietrich CA,Schmaljohann J,Mohammadkhani Shali S,Schabram I,Stoppe C,Cumming P,Hilgers RD,Kumakura Y,Coburn M,Mottaghy FM,Gründer G,Vernaleken I

    更新日期:2016-08-01 00:00:00

  • Which Dopamine Polymorphisms Are Functional? Systematic Review and Meta-analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1, and VMAT2.

    abstract:BACKGROUND:Many polymorphisms in dopamine genes are reported to affect cognitive, imaging, or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the polymorphism on the gene product itself. However, the supporting evidence is not always clear. METHODS...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,meta分析


    authors: Tunbridge EM,Narajos M,Harrison CH,Beresford C,Cipriani A,Harrison PJ

    更新日期:2019-10-15 00:00:00

  • Slowness of movement in melancholic depression.

    abstract::We studied 10 subjects each with melancholic depression evidencing significant motor retardation (RM), Parkinson's disease (PD) with bradykinesia, and normal healthy controls (NC), matched closely for age and gender, on measurements of motor function and depression, and their performance of simple and complex ballisti...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Sachdev P,Aniss AM

    更新日期:1994-02-15 00:00:00

  • Daily stressors, past depression, and metabolic responses to high-fat meals: a novel path to obesity.

    abstract:BACKGROUND:Depression and stress promote obesity. This study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on obesity-related metabolic responses to high-fat meals. METHODS:This double-blind, randomized, crossover study included serial assessments of resting energy expenditur...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Kiecolt-Glaser JK,Habash DL,Fagundes CP,Andridge R,Peng J,Malarkey WB,Belury MA

    更新日期:2015-04-01 00:00:00

  • Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse.

    abstract:BACKGROUND:Previous studies indicate that adverse childhood events are associated with persistent changes in corticotropin-releasing factor neuronal systems. Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma. METHODS:Standard and low-dose dexameth...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Newport DJ,Heim C,Bonsall R,Miller AH,Nemeroff CB

    更新日期:2004-01-01 00:00:00

  • Platelet alpha-2-adrenergic dysfunction in negative symptom schizophrenia: a preliminary study.

    abstract::The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a sign...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rosen J,Silk KR,Rice HE,Smith CB

    更新日期:1985-05-01 00:00:00

  • Time-of-day variations of indicators of attention: performance, physiologic parameters, and self-assessment of sleepiness.

    abstract:BACKGROUND:A study was performed to analyze time-of-day variations of different indicators of attention and their interrelations. METHODS:After a sufficiently long all-night sleep 12 healthy non-sleep-deprived subjects ran through a test battery (Stanford Sleepiness Scale, Visual Analogue Scale, Critical Flicker Fusio...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Kraemer S,Danker-Hopfe H,Dorn H,Schmidt A,Ehlert I,Herrmann WM

    更新日期:2000-12-01 00:00:00

  • Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder.

    abstract:BACKGROUND:22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these re...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Lin A,Vajdi A,Kushan-Wells L,Helleman G,Hansen LP,Jonas RK,Jalbrzikowski M,Kingsbury L,Raznahan A,Bearden CE

    更新日期:2020-08-01 00:00:00

  • Efficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/hyperactivity disorder.

    abstract:BACKGROUND:This multicenter, randomized, fixed-dose, double-blind, placebo-controlled study evaluated efficacy of extended-release dexmethylphenidate (d-MPH-ER) in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS:Randomized adults with ADHD (n=221) received once-daily d-MPH-ER 20 mg, 30 mg, or 40 m...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Spencer TJ,Adler LA,McGough JJ,Muniz R,Jiang H,Pestreich L,Adult ADHD Research Group.

    更新日期:2007-06-15 00:00:00

  • Proton magnetic resonance spectroscopy of basal ganglia in chronic schizophrenia.

    abstract::Proton spectra in the regions of the right and left basal ganglia were studied in 14 medicated patients with chronic schizophrenia using proton magnetic resonance spectroscopy (1H MRS). Ratios of N-acetyl-aspartate (NAA) to choline-containing compounds (Cho) were significantly reduced in the bilateral basal ganglia re...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Fujimoto T,Nakano T,Takano T,Takeuchi K,Yamada K,Fukuzako T,Akimoto H

    更新日期:1996-07-01 00:00:00

  • The developmental psychopathology of social anxiety disorder.

    abstract::The role of developmental theory and developmental psychopathology in understanding the development, maintenance, and course of social anxiety disorder (SAD) is explored in this article. Following a brief examination of the phenomenology of SAD in youth, we provide an overview of the tenets of developmental psychology...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Ollendick TH,Hirshfeld-Becker DR

    更新日期:2002-01-01 00:00:00

  • Estimating the Heritability of Developmental Change in Neural Connectivity, and Its Association With Changing Symptoms of Attention-Deficit/Hyperactivity Disorder.

    abstract:BACKGROUND:Twin studies show that age-related change in symptoms of attention-deficit/hyperactivity disorder (ADHD) is heritable. However, we do not know the heritability of the development of the neural substrates underlying the disorder. Here, we estimated the heritability of developmental change in white matter trac...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Sudre G,Bouyssi-Kobar M,Norman L,Sharp W,Choudhury S,Shaw P

    更新日期:2020-06-13 00:00:00

  • Efficacy of gamma-hydroxybutyrate versus placebo in treating narcolepsy-cataplexy: double-blind subjective measures.

    abstract::The efficacy of gamma-hydroxybutyrate (GHB) versus placebo for treating narcolepsy was evaluated in 20 patients with narcolepsy, 10 men and 10 women, using a double-blind counterbalanced crossover design. Each patient completed a daily sleep-wake log and questionnaire during a 14-day baseline, a 29-day placebo period,...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Scrima L,Hartman PG,Johnson FH Jr,Hiller FC

    更新日期:1989-08-01 00:00:00

  • Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective.

    abstract::The history of psychiatric research is filled with widely accepted etiologic and pathophysiologic theories that eventually were proven wrong. The prevailing pathophysiologic theories of schizophrenia have emphasized the role of abnormal neurodevelopment in determining the onset and course of the illness. Relatively li...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Lieberman JA

    更新日期:1999-09-15 00:00:00

  • Using Clinical Characteristics to Identify Which Patients With Major Depressive Disorder Have a Higher Genetic Load for Three Psychiatric Disorders.

    abstract:BACKGROUND:Limited successes of gene finding for major depressive disorder (MDD) may be partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar disorder, and schizophrenia (SCZ) is increased in phenotypically more homogenous MDD patients identified by specific clinical characteristic...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Verduijn J,Milaneschi Y,Peyrot WJ,Hottenga JJ,Abdellaoui A,de Geus EJC,Smit JH,Breen G,Lewis CM,Boomsma DI,Beekman ATF,Penninx BWJH

    更新日期:2017-02-15 00:00:00

  • Quantitative craniofacial anomalies in a racially mixed schizophrenia sample.

    abstract:BACKGROUND:The observation that some patients with schizophrenia display subtly anomalous craniofacial features dates back to the early 1900s and has recently been hypothesized to reflect disrupted prenatal development also involving the brain. Most studies to date have used observer ratings rather than physical measur...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,随机对照试验


    authors: Donovan-Lepore AM,Jaeger J,Czobor P,Abdelmessih S,Berns SM

    更新日期:2006-02-15 00:00:00

  • Biological stress responses in high and low trait anxious students.

    abstract::In an investigation of biological indicators of stress in normal humans, undergraduate psychology students were differentiated on trait anxiety and assessed under baseline, preexam (stress), and postexam conditions. Assessment at each condition involved drawing 20 ml of blood, followed by self-reporting for selected q...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Davis DD,Dunlop SR,Shea P,Brittain H,Hendrie HC

    更新日期:1985-08-01 00:00:00

  • Perfusion abnormalities and decision making in cocaine dependence.

    abstract:BACKGROUND:Previous studies have shown that cocaine abusers have cerebral perfusion deficits that may diminish cognitive functioning. This study examined whether cocaine-dependent patients have perfusion abnormalities associated with poor decision-making ability as measured by the Iowa Gambling Task (IGT). METHODS:Sev...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Tucker KA,Potenza MN,Beauvais JE,Browndyke JN,Gottschalk PC,Kosten TR

    更新日期:2004-10-01 00:00:00

  • Functional imaging as a predictor of schizophrenia.

    abstract:BACKGROUND:Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS:We studied young individuals with at least two relatives with the di...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Whalley HC,Simonotto E,Moorhead W,McIntosh A,Marshall I,Ebmeier KP,Owens DG,Goddard NH,Johnstone EC,Lawrie SM

    更新日期:2006-09-01 00:00:00

  • Central tryptamine turnover in depression, schizophrenia, and anorexia: measurement of indoleacetic acid in cerebrospinal fluid.

    abstract::There has been a continuing interest in the possible role of the trace amine tryptamine in the etiology of neuropsychiatric disorders. We have therefore examined cerebrospinal fluid (CSF) levels of indole-3-acetic acid (IAA), the major metabolite of tryptamine, in a large group of normals and in several patient popula...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Anderson GM,Gerner RH,Cohen DJ,Fairbanks L

    更新日期:1984-10-01 00:00:00

  • Whole blood serotonin relates to violence in an epidemiological study.

    abstract:BACKGROUND:Clinical and animal studies suggest that brain serotonergic systems may regulate aggressive behavior; however, the serotonin/violence hypothesis has not been assessed at the epidemiological level. For study of an epidemiological sample we examined blood serotonin, because certain physiological and behavioral...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Moffitt TE,Brammer GL,Caspi A,Fawcett JP,Raleigh M,Yuwiler A,Silva P

    更新日期:1998-03-15 00:00:00