CSF beta-endorphin-like immunoreactivity in delirium.

Abstract:

:Cerebrospinal fluid beta-endorphin-like immunoreactivity (CSF BLI) was determined for 69 patients who met DSM-III criteria for delirium and for 8 controls. The CSF BLI was significantly lower in the delirious patient group than in the controls (12.5 +/- 3.0 pg/ml versus 15.0 +/- 3.4 pg/ml, p less than 0.05). CSF BLI had no correlation with age or neuroleptic drug dosage, but did have a significant positive correlation with cognitive functioning as evaluated by the Mini-Mental State. Our findings suggest a role for beta-endorphinergic dysfunction in the development of delirium.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Koponen H,Stenbäck U,Mattila E,Reinikainen K,Soininen H,Riekkinen PJ

doi

10.1016/0006-3223(89)90273-4

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

938-44

issue

7

eissn

0006-3223

issn

1873-2402

pii

0006-3223(89)90273-4

journal_volume

25

pub_type

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