Abstract:
BACKGROUND:Anterior cingulate cortex has been implicated in the pathogenesis of major depressive disorder (MDD). With single voxel proton magnetic resonance spectroscopy, we reported reductions in anterior cingulate glutamatergic concentrations (grouped value of glutamate and glutamine) in 14 pediatric MDD patients versus 14 case-matched healthy control subjects. These changes might reflect a change in glutamate, glutamine, or their combination. METHODS:Fitting to individually quantify anterior cingulate glutamate and glutamine was performed in these subjects with a new basis set created from data acquired on a 1.5 Tesla General Electric Signa (GE Healthcare, Waukesha, Wisconsin) magnetic resonance imaging scanner with LCModel (Version 6.1-0; Max-Planck-Institute, Gottingen, Germany). RESULTS:Reduced anterior cingulate glutamate was observed in MDD patients versus control subjects (8.79 +/- 1.68 vs. 11.46 +/- 1.55, respectively, p = .0002; 23% decrease). Anterior cingulate glutamine did not differ significantly between patients with MDD and control subjects. CONCLUSIONS:These findings provide confirmatory evidence of anterior cingulate glutamate alterations in pediatric MDD.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Rosenberg DR,Macmaster FP,Mirza Y,Smith JM,Easter PC,Banerjee SP,Bhandari R,Boyd C,Lynch M,Rose M,Ivey J,Villafuerte RA,Moore GJ,Renshaw Pdoi
10.1016/j.biopsych.2005.05.007subject
Has Abstractpub_date
2005-11-01 00:00:00pages
700-4issue
9eissn
0006-3223issn
1873-2402pii
S0006-3223(05)00583-4journal_volume
58pub_type
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journal_title:Biological psychiatry
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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