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Cortisol awakening response and hippocampal volume: vulnerability for major depressive disorder?

Abstract：

BACKGROUND:Major depressive disorder is associated with dysregulated basal cortisol levels and small hippocampal (HC) volume. However, it is still debated whether these phenomena are a consequence of the illness or whether they may represent a vulnerability marker existing before the illness onset. Here, we aimed to examine this notion of vulnerability by assessing whether abnormalities in basal cortisol secretion and HC volumes are already present in a sample of healthy young adults who showed varying levels of depressive tendencies, but at subclinical levels. METHODS:We recruited healthy young men and women from the local university. On the basis of depression scores derived from standard questionnaires, three groups were formed: a control group (n = 27), a subclinical group (n = 23), and a high-risk subclinical group (n = 9). The participants underwent a magnetic resonance imaging scan and collected saliva samples for the assessment of diurnal cortisol levels. RESULTS:Both the subclinical and the high-risk subclinical group failed to show a significant increase in cortisol levels after awakening. The high-risk subclinical group also showed a lower area-under-the-curve increase of cortisol levels after awakening compared with control subjects. In addition, this group also had smaller total HC volume compared with control subjects. CONCLUSIONS:The findings from this subclinical sample suggest that dysregulated cortisol awakening response and small HC volume may constitute vulnerability factors for major depressive disorder. Further investigations are needed to discern the mechanisms that may underlie these phenomena.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Dedovic K,Engert V,Duchesne A,Lue SD,Andrews J,Efanov SI,Beaudry T,Pruessner JC

doi

10.1016/j.biopsych.2010.07.025

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

847-53

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(10)00811-5

journal_volume

68

pub_type

杂志文章

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