Abstract：
:There is increasing evidence of a deficit or disturbance of neurons in the brains of schizophrenic patients--evidence that particularly implicates the frontal or temporal lobes. As yet there is no direct neurochemical correlate of the transmitter systems involved, although changes in some neurotransmitters in the temporal lobe have been reported. Radiolabeled nipecotic acid, a specific inhibitor of uptake sites to gamma-aminobutyric acid (GABA), has provided a marker of GABAergic neurons. The binding of this ligand to brain tissue taken at autopsy has demonstrated a decreased density of GABA uptake sites in the hippocampus in schizophrenia. This decrease was found to correlate in the left hemisphere with increased concentration of dopamine in the amygdala, providing a link between neuropathology, evidence of laterality, and the dopamine hypothesis of the disease.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Reynolds GP,Czudek C,Andrews HBdoi
10.1016/0006-3223(90)90039-5subject
Has Abstractpub_date
1990-05-01 00:00:00pages
1038-44issue
9eissn
0006-3223issn
1873-2402pii
0006-3223(90)90039-5journal_volume
27pub_type
杂志文章abstract：BACKGROUND:Head growth rates are often accelerated in autism. This study is aimed at defining the clinical, morphological, and biochemical correlates of head circumference in autistic patients. METHODS:Fronto-occipital head circumference was measured in 241 nonsyndromic autistic patients, 3 to 16 years old, diagnosed ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.04.039
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the amygdala, and hippocampus. Although the contributions of the media...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.03.007
更新日期：2012-08-15 00:00:00
abstract：BACKGROUND:Prior investigations of cross-informant agreement among parents, teachers, and clinicians about externalizing and internalizing problems have not directly addressed agreement about manic symptoms. METHODS:We identified three groups from a large cohort of youths, aged 8-12 years, treated on an inpatient unit...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00068-4
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive procedure that may be used to study individual differences in motor cortex excitability. Such differences are assumed to reflect serotonergic and other inputs to the motor cortex. METHODS:Here we investigate the impact of a functional polymorphism in ...
journal_title：Biological psychiatry
pub_type： 杂志文章,收录出版
doi：10.1016/j.biopsych.2009.02.005
更新日期：2009-08-01 00:00:00
abstract：:The dexamethasone suppression test (DST) and sleep EEG were compared in three different descriptive diagnostic schemes in 70 adult patients with nonpsychotic, unipolar major depressive disorder according to Research Diagnostic Criteria. Endogenous (E)/nonendogenous (NE), primary/secondary, and Winokur's family history...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:Olfactory sensitivity to two odorants, isoamyl acetate and androsterone, was assessed in 14 obsessive compulsive disorder (OCD) patients, nine major depressive disorder (MDD) patients, and 16 sex- and age-matched healthy controls. Tests were performed during a drug-free period, and 3 and 6 weeks after initiation of an...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)91142-8
更新日期：1994-05-15 00:00:00
abstract：BACKGROUND:Only about one third of patients at high risk for psychosis based on current clinical criteria convert to a psychotic disorder within a 2.5-year follow-up period. Targeting clinical high-risk (CHR) individuals for preventive interventions could expose many to unnecessary treatments, underscoring the need to ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2013.07.038
更新日期：2014-03-15 00:00:00
abstract：BACKGROUND:Striatal enlargement with chronic neuroleptic treatment in schizophrenic patients has been reported by several investigators. Longitudinal magnetic resonance imaging studies of patients suggest that changes in striatal volume may be caused by treatment with antipsychotic medication. METHODS:We have examined...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00029-8
更新日期：1998-10-15 00:00:00
abstract：BACKGROUND:Posttraumatic stress disorder (PTSD) is marked by intrusive, chronic, and distressing memories of highly emotional events. Previous research has highlighted the role of the amygdala and its interactions with the hippocampus in mediating the effect of enhanced memory for emotional information in healthy indiv...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2010.07.018
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Marked interindividual differences in vulnerability to nicotine dependence exist, but factors underlying such differences are not well understood. The midbrain alpha4beta2* subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediation of the reinforcing effects of nicotine responsibl...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.09.036
更新日期：2009-04-15 00:00:00
abstract：:Visibility of the nailfold vascular plexus has shown promise as a genetically transmitted marker for liability to schizophrenia. To assess whether this marker is specifically associated with negative or positive symptoms of schizophrenia, we reanalyzed patient data collected 20 years ago, well before interest in the n...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90195-r
更新日期：1991-04-15 00:00:00
abstract：:The pharmacokinetics of dexamethasone (DEX) were studied in 9 drug-free melancholically depressed patients and 10 healthy control subjects matched by sex and age. Each subject received 1 mg of DEX administered orally and by the (i.v.) route at 11:00 PM and serial blood samples were collected over the next 17 hours unt...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(96)00094-7
更新日期：1997-03-01 00:00:00
abstract：:Pre-treatment and posttreatment dexamethasone suppression test (DST) results in physically healthy elderly major depressives without dementia demonstrated an association between treatment and DST normalization. Sixty percent of subjects were nonsuppressors at baseline compared to 17% after intensive treatment. DST res...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90263-d
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Reduction of P300 amplitude in children and adolescents at high risk for developing alcoholism has frequently been reported. It has been hypothesized that this reduction represents a developmental delay in reaching age-appropriate levels in P300 amplitude. Using latent growth analysis of longitudinal data ob...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00032-3
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Accumulating evidence suggests the involvement of inflammatory processes and cytokines in particular in the pathophysiology of major depression (MDD) and resistance to antidepressant treatment. Furthermore, amygdala and anterior cingulate cortex (ACC) responsiveness to emotional stimuli has been suggested as...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.11.004
更新日期：2010-03-15 00:00:00
abstract：BACKGROUND:Previous studies indicate that adverse childhood events are associated with persistent changes in corticotropin-releasing factor neuronal systems. Our aim was to determine whether altered glucocorticoid feedback mediates the neuroendocrine sequelae of childhood trauma. METHODS:Standard and low-dose dexameth...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00692-9
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Reinforcement of behavioral responses involves a complex cerebral circuit engaging specific neuronal networks that are modulated by cortical oversight systems affiliated with emotion, memory, judgment, and decision making (collectively referred to in this study as the "extended reward and oversight system" o...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.01.018
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Transcription factors of the Nur family (Nurr1, Nur77, and Nor-1) are orphan nuclear receptors closely associated with dopamine neurotransmission in the central nervous system. Nur77 expression is strongly modulated by antipsychotic and ant-parkinsonian drugs in dopaminoceptive brain areas. However, the role...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.04.023
更新日期：2006-09-15 00:00:00
abstract：:Concentrations of the three main monoamines (5-HT, NA, and DA), their metabolites (5-HIAA, DOPAC, and HVA), and the serotonin precursor 5-hydroxy-L-tryptophan were simultaneously measured in frontal cortex, gyrus cinguli, and hypothalamus from 23 controls and 18 suicide victims. Overall suicides did not show significa...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(96)00239-9
更新日期：1997-05-15 00:00:00
abstract：:The effects of naltrexone on both mood and cognition were examined in overweight male subjects. Subjects were randomly prescribed, in a double-blind fashion, either placebo or naltrexone for 8 weeks. The results of the study showed that a chronic administration of a high dose of naltrexone (300 mg/day) does not signif...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0006-3223(86)90050-8
更新日期：1986-03-01 00:00:00
abstract：BACKGROUND:Abnormalities at several levels of the hypothalamic-pituitary-adrenal axis, which may promote glucocorticoid dependent neurodegeneration, have been reported in patients with Alzheimer's disease. In this study we have explored the possibility that peripheral cortisol metabolism is enhanced and glucocorticoid ...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(00)01015-5
更新日期：2001-03-15 00:00:00
abstract：BACKGROUND:It is widely considered that exposure to maternal cigarette smoking in pregnancy has risk effects on offspring attention-deficit/hyperactivity disorder (ADHD). This view is supported by consistent observations of association. It is, however, impossible to be certain of adequate control for confounding factor...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.05.032
更新日期：2009-10-15 00:00:00
abstract：:The intuitive association between self-focused rumination in major depressive disorder (MDD) and the self-referential operations performed by the brain's default-mode network (DMN) has prompted interest in examining the role of the DMN in MDD. In this article, we present meta-analytic findings showing reliably increas...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.02.020
更新日期：2015-08-15 00:00:00
abstract：BACKGROUND:To determine the effects of depressive symptom severity on the circulating soluble adhesion molecule response to an acute exercise challenge in patients with heart failure (HF) compared with control subjects. METHODS:Thirty-eight male HF patients and 19 male control subjects (mean age +/- SEM: 55.5 +/- 1.9)...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2008.11.013
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:The relationship between vitamin status and cognitive functioning has been addressed in several recent studies with inconclusive results. The purpose of this study was to examine separate and combined effects of serum vitamin B12 and folic acid on episodic memory functioning in very old age. METHODS:Four st...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(98)00234-0
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Marijuana use by teenagers often predates the use of harder drugs, but the neurobiological underpinnings of such vulnerability are unknown. Animal studies suggest enhanced heroin self-administration (SA) and dysregulation of the endogenous opioid system in the nucleus accumbens shell (NAcsh) of adults follow...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2012.04.026
更新日期：2012-11-15 00:00:00
abstract：BACKGROUND:The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological systems (e.g., inflammation, oxidative stress) and induces peripher...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2019.02.006
更新日期：2019-06-15 00:00:00
abstract：:Mismatch negativity (MMN), in the deviant-minus-standard event-related potential (ERP) difference-waveform, may represent a working memory trace of the tone difference. Most but not all studies find MMN reduced in schizophrenic patients. This report investigates if differences may be attributable to experimental condi...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(96)00214-4
更新日期：1997-06-15 00:00:00
abstract：BACKGROUND:Binge eating is associated with obesity and has been conceptualized as "food addiction." However, this view has received only inconsistent support in humans, and limited evidence relates key neurocircuitry to the disorder. Moreover, relatively few studies have used pharmacologic functional magnetic resonance...
journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2012.10.022
更新日期：2013-05-01 00:00:00
abstract：:Our previous studies have shown that in psychotics, the plasma serine level is abnormally high and that plasma serine hydroxymethyltransferase (which cleaves serine to glycine) activity is abnormally low as compared with that in nonpsychotic subjects. In this study, psychotic and nonpsychotic subjects ingested a large...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(85)90133-7
更新日期：1985-01-01 00:00:00
