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Noradrenergic function in generalized anxiety disorder, major depressive disorder, and healthy subjects.

Abstract：

:Plasma norepinephrine (NE), free 3-methoxy-4-hydroxyphenethylene glycol (MHPG), and binding of tritiated yohimbine to platelet membranes were measured in 14 patients with generalized anxiety disorder (GAD), who were matched for age and sex with 14 patients with unipolar major depressive disorder (MDD) and 14 normal subjects. Plasma NE and MHPG levels were increased and the number of alpha2-adrenoreceptors (Bmax) was decreased in GAD patients compared with MDD and normal subjects. No differences were found between MDD patients and normal subjects for plasma NE, MHPG, and alpha2-adrenoreceptor binding. Plasma NE and MHPG were significantly correlated in MDD patients and tended toward a significant positive correlation in GAD patients. Plasma MHPG and affinity of binding platelet alpha2-adrenoreceptors (Kd) were significantly correlated in normal subjects. Thus, noradrenergic activity seems to be increased in patients with GAD, but not in patients with MDD. In GAD patients, higher levels of catecholamines may lead to a down-regulation of presynaptic alpha2-adrenoreceptors.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Sevy S,Papadimitriou GN,Surmont DW,Goldman S,Mendlewicz J

doi

10.1016/0006-3223(89)90158-3

subject

Has Abstract

pub_date

1989-01-15 00:00:00

pages

141-52

issue

2

eissn

0006-3223

issn

1873-2402

pii

0006-3223(89)90158-3

journal_volume

25

pub_type

杂志文章

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