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Thyrotropin response to thyrotropin-releasing hormone in patients with dementia of the Alzheimer type.

Abstract：

:Eleven patients with senile dementia of the Alzheimer type and 11 age-matched control subjects were given the thyrotropin-releasing hormone (TRH) test. The two groups did not differ with respect to peak thyrotropin (TSH) response or TSH levels at baseline, 20, 30, and 45 min after TRH injection. There were significant differences between the groups on Hamilton Depression Rating Scale scores (p < 0.03), although neither group met clinical criteria for depression. Items that were significantly different pertained to depressed mood, loss of interest, loss of insight, suicidal ideation, and obsessional symptoms.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Albert M,Jenike M,Nixon R,Nobel K

doi

10.1016/0006-3223(93)90293-m

subject

Has Abstract

pub_date

1993-02-15 00:00:00

pages

267-71

issue

4

eissn

0006-3223

issn

1873-2402

pii

0006-3223(93)90293-M

journal_volume

33

pub_type

杂志文章

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