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Association of 5-HT(2A) receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk.

Abstract：

BACKGROUND:The implication of serotonin in suicide and affective disease explains why the 5-HT(2A) receptor gene has been proposed as a candidate gene in these disorders, although with conflicting results. METHODS:We analysed the distribution of the 5-HT(2A)-1438A/G genetic polymorphism in 192 patients with major affective disorder (127 bipolar disorders and 65 unipolar disorders) compared to 142 healthy control subjects. RESULTS:We found a higher frequency of the A allele in affected patients than in control subjects (p =.034), this difference being particularly striking for the subgroup of patients with type I bipolar disorder (p =.015). Patients with no personal and/or familial history of suicide attempts mainly accounted for the excess of the A allele in affected patients. CONCLUSIONS:The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Bonnier B,Gorwood P,Hamon M,Sarfati Y,Boni C,Hardy-Bayle MC

doi

10.1016/s0006-3223(01)01228-8

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

762-5

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006322301012288

journal_volume

51

pub_type

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