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Use of bupropion in combination with serotonin reuptake inhibitors.

Abstract：

:Incomplete symptom remission and sexual side effects are common problems for which bupropion often is added to treatment with selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRIs and SNRIs) for patients with major depressive disorder (MDD). This article reviews the literature on combining bupropion with SSRIs or SNRIs. We used MEDLINE to select studies that included patients diagnosed with MDD treated with any combination of bupropion and an SSRI or SNRI, either to enhance antidepressant response or to ameliorate antidepressant-associated sexual dysfunction. Bibliographies of located articles were searched for additional studies. Controlled and open-label studies support the effectiveness of bupropion in reversing antidepressant-associated sexual dysfunction, whereas open trials suggest that combination treatment with bupropion and an SSRI or SNRI is effective for the treatment of MDD in patients refractory to the SSRI, SNRI, or bupropion alone. The available data suggest that, although not an approved indication, the combination of bupropion and either an SSRI or an SNRI is generally well tolerated, can boost antidepressant response, and can reduce SSRI or SNRI-associated sexual side effects. Additional randomized controlled studies are needed to answer important questions, such as those regarding optimal dose and duration of treatment.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Zisook S,Rush AJ,Haight BR,Clines DC,Rockett CB

doi

10.1016/j.biopsych.2005.06.027

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

203-10

issue

3

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(05)00820-6

journal_volume

59

pub_type

杂志文章,评审

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