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The question of PANDAS in adults.

Abstract：

BACKGROUND:Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a well-defined cause of obsessive-compulsive disorder in children. However, they have not been described or fully investigated in adults newly diagnosed with obsessive-compulsive disorder. METHODS:We describe an adult with onset of obsessive-compulsive disorder at 25 years of age after a severe antibiotic-responsive pharyngitis. He was evaluated with multiple psychiatric rating scales for obsessive-compulsive disorder and Tourette's syndrome, as well as with serologic assays and radiologic studies. RESULTS:In all respects except age our patient fulfilled established criteria for PANDAS. Assays for antibodies to group A beta-hematolytic streptococci, serum D8,17 lymphocytes, antistriatal (neuronal) antibodies, and anticytoskeletal antibodies all supported the hypothesis that a poststreptococcal process was active. Magnetic resonance imaging was abnormal and is described. CONCLUSIONS:The findings suggest that this patient's illness is similar to PANDAS in presentation and that poststreptococcal disease may result in adult-onset obsessive-compulsive disorder.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Bodner SM,Morshed SA,Peterson BS

doi

10.1016/s0006-3223(00)01127-6

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

807-10

issue

9

eissn

0006-3223

issn

1873-2402

pii

S0006322300011276

journal_volume

49

pub_type

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