Abstract：
BACKGROUND:Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN). METHODS:To assess possibly trait-related disturbances but avoid confounding effects of malnutrition, 10 women who were recovered from AN (REC AN) were compared with 12 healthy control women (CW). Positron emission tomography with [(11)C]raclopride was used to assess DA D2/D3 receptor binding. RESULTS:The women who were recovered from AN had significantly higher [(11)C]raclopride binding potential in the antero-ventral striatum than CW. For REC AN, [(11)C]raclopride binding potential was positively related to harm avoidance in the dorsal caudate and dorsal putamen. CONCLUSIONS:These data lend support for the possibility that decreased intrasynaptic DA concentration or increased D2/D3 receptor density or affinity is associated with AN and might contribute to the characteristic harm avoidance or increased physical activity found in AN. Most intriguing is the possibility that individuals with AN might have a DA related disturbance of reward mechanisms contributing to altered hedonics of feeding behavior and their ascetic, anhedonic temperament.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Frank GK,Bailer UF,Henry SE,Drevets W,Meltzer CC,Price JC,Mathis CA,Wagner A,Hoge J,Ziolko S,Barbarich-Marsteller N,Weissfeld L,Kaye WHdoi
10.1016/j.biopsych.2005.05.003subject
Has Abstractpub_date
2005-12-01 00:00:00pages
908-12issue
11eissn
0006-3223issn
1873-2402pii
S0006-3223(05)00576-7journal_volume
58pub_type
临床试验,杂志文章abstract：BACKGROUND:This study has two goals: 1) to establish a generalizable model of the symptoms observed in outpatients with major depressive disorder (MDD); and 2) to compare symptom coverage of the Inventory of Depressive Symptomatology, Clinician-Rated (IDS-C) and Self-Report (IDS-SR) to that of the Hamilton Depression R...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-3223(98)00235-2
更新日期：1998-11-15 00:00:00
abstract：:The categorical approach to defining schizophrenia spectrum disorders requires meeting established criteria. To advance early identification and intervention in young people, the field has progressed to studying help-seeking individuals who are at clinical high risk based on subthreshold psychosis spectrum symptoms, a...
journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2020-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(03)00114-8
更新日期：2003-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2020.04.001
更新日期：2020-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(03)00009-x
更新日期：2003-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2007-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2005-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-09-01 00:00:00
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更新日期：2000-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(97)00277-1
更新日期：1998-04-01 00:00:00
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更新日期：1986-08-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1996-10-15 00:00:00
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更新日期：1993-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0006-3223(91)90163-g
更新日期：1991-07-15 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-10-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-06-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-11-15 00:00:00
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更新日期：1989-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-08-15 00:00:00
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更新日期：1993-07-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：1989-01-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2011-02-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2014-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2009-10-15 00:00:00
