当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants.

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants.

Abstract：

BACKGROUND:Because researchers have reported that antidepressants increase the expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus, we investigated whether serum BDNF levels may be used as a putative biological marker for major depressive disorders (MDD). METHODS:We measured serum BDNF in the following three groups: antidepressant-naive patients with MDD (n = 16), antidepressant-treated patients with MDD (n = 17), and normal control subjects (n = 50). Patients were evaluated using the Hamilton Rating Scale for Depression (HAM-D). Serum BDNF was assayed with the sandwich ELISA method. RESULTS:We found that serum BDNF was significantly lower in the antidepressant-naive group (mean, 17.6 ng/mL; SD, 9.6) than in the treated (mean, 30.6 ng/mL; SD, 12.3; p =.001) or in the control group (mean, 27.7 ng/mL; SD, 11.4; p =.002). There was a significant negative correlation (r = -.350, z = -2.003, p =.045) between serum BDNF and HAM-D scores in all patients. In a preliminary examination, reduced BDNF values of three drug-naive patients recovered to basal levels after antidepressant treatment. CONCLUSIONS:Our study suggests that low BDNF levels may play a pivotal role in the pathophysiology of MDD and that antidepressants may increase BDNF in depressed patients.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Shimizu E,Hashimoto K,Okamura N,Koike K,Komatsu N,Kumakiri C,Nakazato M,Watanabe H,Shinoda N,Okada S,Iyo M

doi

10.1016/s0006-3223(03)00181-1

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

70-5

issue

1

eissn

0006-3223

issn

1873-2402

pii

S0006322303001811

journal_volume

54

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Pupillary and reaction time measures of sustained processing of negative information in depression.

    abstract：BACKGROUND:Disruptions of emotional information processing (i.e., attention to, memory for, and interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological features of a particularly promising correl...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(00)01024-6

    authors： Siegle GJ,Granholm E,Ingram RE,Matt GE

    更新日期：2001-04-01 00:00:00

  • Markers of Psychosis Risk in the General Population.

    abstract：:The categorical approach to defining schizophrenia spectrum disorders requires meeting established criteria. To advance early identification and intervention in young people, the field has progressed to studying help-seeking individuals who are at clinical high risk based on subthreshold psychosis spectrum symptoms, a...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/j.biopsych.2020.02.002

    authors： Taylor JH,Calkins ME,Gur RE

    更新日期：2020-08-15 00:00:00

  • Preliminary evidence of riluzole efficacy in antidepressant-treated patients with residual depressive symptoms.

    abstract：BACKGROUND:Excessive glutamatergic neurotransmission may contribute to the pathophysiology of major depressive disorder (MDD). Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity. METHODS:Ten patients with treatment-resistant depression had r...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2006.08.037

    authors： Sanacora G,Kendell SF,Levin Y,Simen AA,Fenton LR,Coric V,Krystal JH

    更新日期：2007-03-15 00:00:00

  • Determination of the optimal concentration of lithium for the prophylaxis of manic-depressive disorder.

    abstract：:A group of 29 bipolar manic-depressives completed a 12-month double-blind cross-over trial of low-dose and high-dose lithium prophylaxis. Twelve patients relapsed, and significantly more of the relapses occurred during the low-dose 6-month phase of the trial. There was a trend for relapse to occur within 2 months of a...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Waters B,Lapierre Y,Gagnon A,Cahudhry R,Tremblay A,Sarantidis D,Gray R

    更新日期：1982-11-01 00:00:00

  • Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses.

    abstract：BACKGROUND:Neurons in the basal ganglia are connected to areas of prefrontal cerebral cortex involved in higher cognitive functions, and these connections occur primarily via the thalamus. In patients with bipolar disorder, regardless of age, neuroimaging studies have consistently reported an increased number of white ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.01.002

    authors： Haznedar MM,Roversi F,Pallanti S,Baldini-Rossi N,Schnur DB,Licalzi EM,Tang C,Hof PR,Hollander E,Buchsbaum MS

    更新日期：2005-04-01 00:00:00

  • The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar disorder I and its clinical correlates.

    abstract：BACKGROUND:Cognitive abnormalities are increasingly recognized as a feature of bipolar I disorder (BDI,) but there is limited information regarding the pattern and severity of cognitive impairment during remission and its relationship with clinical variables. METHODS:Forty-four remitted BDI patients recruited from a r...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2005.04.056

    authors： Frangou S,Donaldson S,Hadjulis M,Landau S,Goldstein LH

    更新日期：2005-12-01 00:00:00

  • The response of lymphocyte beta-adrenergic receptors to chronic propranolol treatment in depressed patients, schizophrenic patients, and normal controls.

    abstract：:The ability of beta-adrenergic receptors to adapt to reductions in stimulation might be impaired in depressed or schizophrenic patients. To test this hypothesis 12 normal controls, 12 depressed patients resistant to tricyclic antidepressants, and 8 chronic schizophrenic patients were treated with propranolol 160 mg/da...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Zohar J,Bannet J,Drummer D,Fisch R,Epstein RP,Belmaker RH

    更新日期：1983-05-01 00:00:00

  • The TRH-stimulation test in DSM-III personality disorder.

    abstract：:The authors examined thyrotropin-releasing hormone (TRH) stimulation testing in the neuroendocrine evaluation of DSM-III major depressive disorder in 26 consecutive medication-free, medically healthy patients meeting a primary DSM-III diagnosis of axis II personality disorder. Thyroid-stimulating hormone (TSH) respons...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(93)90077-q

    authors： Kavoussi RJ,Coccaro EF,Klar H,Lesser J,Siever LJ

    更新日期：1993-08-15 00:00:00

  • Personality traits of agreeableness and extraversion are associated with ADH4 variation.

    abstract：BACKGROUND:Personality traits are associated with substance dependence (SD); genetic factors may influence both. Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study. METHODS:We assessed dimensi...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.05.017

    authors： Luo X,Kranzler HR,Zuo L,Wang S,Gelernter J

    更新日期：2007-03-01 00:00:00

  • Chronic antidepressant treatment impairs the acquisition of fear extinction.

    abstract：BACKGROUND:Like fear conditioning, the acquisition phase of extinction involves new learning that is mediated by the amygdala. During extinction training, the conditioned stimulus is repeatedly presented in the absence of the unconditioned stimulus, and the expression of previously learned fear gradually becomes suppre...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.10.012

    authors： Burghardt NS,Sigurdsson T,Gorman JM,McEwen BS,LeDoux JE

    更新日期：2013-06-01 00:00:00

  • The effects of psychotherapy on neural responses to rewards in major depression.

    abstract：BACKGROUND:Unipolar major depressive disorder (MDD) is characterized by anomalous neurobiological responses to pleasant stimuli, a pattern that may be linked to symptoms of anhedonia. However, the potential for psychotherapy to normalize neurobiological responses to pleasant stimuli has not been evaluated. METHODS:Twe...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.06.021

    authors： Dichter GS,Felder JN,Petty C,Bizzell J,Ernst M,Smoski MJ

    更新日期：2009-11-01 00:00:00

  • EEG-monitored sleep in anorexia nervosa and bulimia.

    abstract：:We compared the EEG-monitored sleep of 8 women with anorexia nervosa and 16 normal weight women with bulimia to that of 14 normal women. The patients with anorexia nervosa spent less time asleep and spent less of their sleep time in Stage 1. The sleep of the normal weight patients with bulimia was remarkably similar t...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(85)90191-x

    authors： Walsh BT,Goetz R,Roose SP,Fingeroth S,Glassman AH

    更新日期：1985-09-01 00:00:00

  • Unaffected family members and schizophrenia patients share brain structure patterns: a high-dimensional pattern classification study.

    abstract：BACKGROUND:A number of studies have provided evidence for genetic modulation of brain structure in unaffected family members (FM) of schizophrenia patients using conventional volumetric analysis. High-dimensional pattern classification methods have been reported to have the capacity to determine subtle and spatially co...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2007.03.015

    authors： Fan Y,Gur RE,Gur RC,Wu X,Shen D,Calkins ME,Davatzikos C

    更新日期：2008-01-01 00:00:00

  • Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings.

    abstract：BACKGROUND:Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.02.024

    authors： Zhou K,Asherson P,Sham P,Franke B,Anney RJ,Buitelaar J,Ebstein R,Gill M,Brookes K,Buschgens C,Campbell D,Chen W,Christiansen H,Fliers E,Gabriëls I,Johansson L,Marco R,Mulas F,Müller U,Mulligan A,Neale BM,Rijsdij

    更新日期：2008-10-01 00:00:00

  • HPA axis dysregulation in mice overexpressing corticotropin releasing hormone.

    abstract：BACKGROUND:Hypersecretion of corticotropin-releasing hormone (CRH) in the brain has been implicated in stress-related human pathologies. We developed a transgenic mouse line overexpressing CRH (CRH-OE) exclusively in neural tissues to assess the effect of long-term CRH overproduction on regulation of the hypothalamic-p...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(02)01334-3

    authors： Groenink L,Dirks A,Verdouw PM,Schipholt Ml,Veening JG,van der Gugten J,Olivier B

    更新日期：2002-06-01 00:00:00

  • The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases.

    abstract：BACKGROUND:We evaluated the comparative efficacy and safety of venlafaxine extended release (ER) and fluoxetine in the acute and continuation phases of treatment. METHODS:In this multicenter, double-blind study, outpatients with recurrent unipolar major depression were randomly assigned to receive venlafaxine ER (75-3...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.biopsych.2007.04.040

    authors： Keller MB,Trivedi MH,Thase ME,Shelton RC,Kornstein SG,Nemeroff CB,Friedman ES,Gelenberg AJ,Kocsis JH,Dunner DL,Dunlop BW,Hirschfeld RM,Rothschild AJ,Ferguson JM,Schatzberg AF,Zajecka JM,Pedersen R,Yan B,Ahmed S,Schm

    更新日期：2007-12-15 00:00:00

  • Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence.

    abstract：BACKGROUND:Comparing prefrontal cortical activity during particular phases of working memory in healthy subjects and individuals diagnosed with schizophrenia might help to define the phase-specific deficits in cortical function that contribute to cognitive impairments associated with schizophrenia. This study featured ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.07.029

    authors： Driesen NR,Leung HC,Calhoun VD,Constable RT,Gueorguieva R,Hoffman R,Skudlarski P,Goldman-Rakic PS,Krystal JH

    更新日期：2008-12-15 00:00:00

  • Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes.

    abstract：BACKGROUND:We investigated the impact of depression and inflammatory markers, assessed 2 months after acute coronary syndrome (ACS), on major adverse cardiac events over 2 years (MACEs; cardiac death, survived myocardial infarction, survived cardiac arrest, and nonelective revascularization). METHODS:Depression sympto...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.biopsych.2006.09.029

    authors： Frasure-Smith N,Lespérance F,Irwin MR,Sauvé C,Lespérance J,Théroux P

    更新日期：2007-08-15 00:00:00

  • Predictors of the course of tardive dyskinesia in patients receiving neuroleptics.

    abstract：:As many patients still require maintenance neuroleptic medication, it is important to determine what factors affect the course of tardive dyskinesia (TD) during ongoing neuroleptic treatment. In this study the data are from a series of annual examinations using the Abnormal Involuntary Movement Scale (AIMS) in a cohor...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90071-7

    authors： Bergen J,Kitchin R,Berry G

    更新日期：1992-10-01 00:00:00

  • A Connectome-wide Functional Signature of Transdiagnostic Risk for Mental Illness.

    abstract：BACKGROUND:High rates of comorbidity, shared risk, and overlapping therapeutic mechanisms have led psychopathology research toward transdiagnostic dimensional investigations of clustered symptoms. One influential framework accounts for these transdiagnostic phenomena through a single general factor, sometimes referred ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.03.012

    authors： Elliott ML,Romer A,Knodt AR,Hariri AR

    更新日期：2018-09-15 00:00:00

  • Trajectory and Predictors of Depression and Anxiety Disorders in Mothers With the FMR1 Premutation.

    abstract：BACKGROUND:Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability, and predictors of mood and anxiety diso...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.07.015

    authors： Roberts JE,Tonnsen BL,McCary LM,Ford AL,Golden RN,Bailey DB Jr

    更新日期：2016-05-15 00:00:00

  • Probing Brain Developmental Patterns of Myelination and Associations With Psychopathology in Youths Using Gray/White Matter Contrast.

    abstract：BACKGROUND:Cerebral myeloarchitecture shows substantial development across childhood and adolescence, and aberrations in these trajectories are relevant for a range of mental disorders. Differential myelination between intracortical and subjacent white matter can be approximated using signal intensities in T1-weighted ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2018.09.027

    authors： Norbom LB,Doan NT,Alnæs D,Kaufmann T,Moberget T,Rokicki J,Andreassen OA,Westlye LT,Tamnes CK

    更新日期：2019-03-01 00:00:00

  • IRB review of psychiatric medication discontinuation and symptom-provoking studies.

    abstract：:Federal regulations governing human subjects research call for additional protections for the "mentally disabled." However, there is currently no consensus definition of mental disability or guidelines for how these research subjects should be protected. This ambiguity complicates the work of institutional review boar...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(99)00168-7

    authors： Rosenstein DL

    更新日期：1999-10-15 00:00:00

  • Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N-Methyl-D-Aspartate Receptor Subunit.

    abstract：BACKGROUND:Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects indu...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.08.013

    authors： Tozzi A,de Iure A,Bagetta V,Tantucci M,Durante V,Quiroga-Varela A,Costa C,Di Filippo M,Ghiglieri V,Latagliata EC,Wegrzynowicz M,Decressac M,Giampà C,Dalley JW,Xia J,Gardoni F,Mellone M,El-Agnaf OM,Ardah MT,Puglisi-A

    更新日期：2016-03-01 00:00:00

  • Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system.

    abstract：BACKGROUND:Animal studies demonstrate that stress and negative affect enhance the release of the neuropeptide substance P (SP), which binds to the neurokinin 1 (NK1) receptor. This positron emission tomography (PET) study evaluated how the activity in the SP-NK1 receptor system in the amygdala was affected by fear prov...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2006.07.003

    authors： Michelgård A,Appel L,Pissiota A,Frans O,Långström B,Bergström M,Fredrikson M

    更新日期：2007-04-15 00:00:00

  • Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder.

    abstract：BACKGROUND:Current pathophysiologic models of attention-deficit/hyperactivity disorder (ADHD) suggest that impaired functional connectivity within brain attention networks may contribute to the disorder. In this electroencephalographic (EEG) study, we analyzed cross-frequency amplitude correlations to investigate diffe...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2009.11.022

    authors： Mazaheri A,Coffey-Corina S,Mangun GR,Bekker EM,Berry AS,Corbett BA

    更新日期：2010-04-01 00:00:00

  • Adrenocortical function and plasma norepinephrine in normal human subjects.

    abstract：:Abnormal adrenocortical regulation has been reported in patients with endogenous depression, including excessive cortisol production with loss of circadian periodicity and decreased suppression by dexamethasone. The inhibitory effect of the neurotransmitter norepinephrine (NE) on the hypothalamic-pituitary adrenal (HP...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Sotsky SM,Lake CR,Goodwin FK

    更新日期：1981-07-01 00:00:00

  • A time-dependent history of mood disorders in a murine model of neuropathic pain.

    abstract：BACKGROUND:Chronic pain is clinically associated with the development of affective disorders. However, studies in animal models of neuropathic pain are contradictory and the relationship with mood disorders remains unclear. In this study, we aimed to characterize the affective consequences of neuropathic pain over time...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.07.017

    authors： Yalcin I,Bohren Y,Waltisperger E,Sage-Ciocca D,Yin JC,Freund-Mercier MJ,Barrot M

    更新日期：2011-11-15 00:00:00

  • Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant.

    abstract：BACKGROUND:Evidence suggests that structural brain changes occur over time in bipolar disorder but few studies have examined this longitudinally. Additional work implicates brain-derived neurotrophic factor (BDNF) valine (val)(66)methionine (met) variant in these changes. The present study examined longitudinal trends ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2008.12.006

    authors： Mirakhur A,Moorhead TW,Stanfield AC,McKirdy J,Sussmann JE,Hall J,Lawrie SM,Johnstone EC,McIntosh AM

    更新日期：2009-08-01 00:00:00

  • The neuropsychological profile of psychotic major depression and its relation to cortisol.

    abstract：BACKGROUND:Our study described the neuropsychological profile of psychotic major depression (PMD) compared to nonpsychotic major depression (NPMD) patients and psychiatrically healthy controls (HC). We predicted that higher cortisol levels would be associated with greater cognitive deficits. METHODS:Twenty-nine PMDs, ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.11.010

    authors： Gomez RG,Fleming SH,Keller J,Flores B,Kenna H,DeBattista C,Solvason B,Schatzberg AF

    更新日期：2006-09-01 00:00:00