Abstract：
BACKGROUND:Disruptions of emotional information processing (i.e., attention to, memory for, and interpretation of emotional information) have been implicated in the onset and maintenance of depression. The research presented here investigated cognitive and psychophysiological features of a particularly promising correlate of depression: sustained processing of negative information 4--5 sec after an emotional stimulus. METHODS:Pupil dilation data and reaction times were collected from 24 unmedicated depressed and 25 nondepressed adults in response to emotional processing tasks (lexical decision and valence identification) that employed idiosyncratically generated personally relevant and normed stimuli. Pupil dilation was used to index sustained cognitive processing devoted to stimuli. RESULTS:Consistent with predictions, depressed individuals were especially slow to name the emotionality of positive information, and displayed greater sustained processing (pupil dilation) than nondepressed individuals when their attention was directed toward emotional aspects of information. Contrary to predictions, depressed participants did not dilate more to negative than positive stimuli, compared to nondepressed participants. CONCLUSIONS:These data suggest depressed individuals may not initially attend to emotional aspects of information but may continue to process them seconds after they have reacted to the information.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Siegle GJ,Granholm E,Ingram RE,Matt GEdoi
10.1016/s0006-3223(00)01024-6subject
Has Abstractpub_date
2001-04-01 00:00:00pages
624-36issue
7eissn
0006-3223issn
1873-2402pii
S0006322300010246journal_volume
49pub_type
杂志文章abstract：BACKGROUND:A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other ...
journal_title：Biological psychiatry
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
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abstract：BACKGROUND:The high-risk strategy is one of the most powerful approaches for identifying premorbid risk factors and reducing etiologic and phenotypic heterogeneity characteristic of the major psychiatric disorders. METHODS:This paper reviews the methods of high-risk research and findings from previous high-risk studie...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Biological psychiatry
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Biological psychiatry
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doi：
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更新日期：2003-10-15 00:00:00
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journal_title：Biological psychiatry
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doi：
更新日期：1984-07-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
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更新日期：2005-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(88)90033-9
更新日期：1988-02-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(94)90059-0
更新日期：1994-07-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/s0006-3223(99)00158-4
更新日期：1999-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90248-k
更新日期：1991-06-01 00:00:00
