Abstract:
BACKGROUND:To test the hypothesis that depression is associated with an increased ratio of cholinergic to serotonergic neurotransmission, we compared the effects of pilocarpine, a muscarinic agonist, and ipsapirone, a serotonin (5-HT)1A agonist, on electroencephalographic (EEG) sleep in depressed and healthy subjects. We hypothesized, adopting the reciprocal interaction model, that the effects on REM sleep of these probes within the same individuals are negatively correlated and unmask neurobiological changes in depression. METHODS:Polysomnographic recordings were obtained in 12 unmedicated patients with a current major depression and 12 normal controls. They received placebo, pilocarpine 25 mg, or ipsapirone 10 mg (orally, 15 min before bedtime, after premedication with the peripheral anticholinergic probanthine 30 mg, double blind, counterbalanced) on three occasions. RESULTS:Pilocarpine shortened and ipsapirone prolonged REM latency equally in both groups. These effects were not correlated. Pilocarpine decreased slow-wave sleep and EEG delta power during the first nonREM episode more in controls than in patients, and enhanced EEG sigma power equally in both groups. Ipsapirone had no significant effects on EEG power. CONCLUSION:These data do not support the postulate of muscarinic receptor up-regulation and 5-HT1A receptor down-regulation in depression. The significance of blunted delta power suppression in patients following pilocarpine warrants further investigations.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Seifritz E,Gillin JC,Rapaport MH,Kelsoe JR,Bhatti T,Stahl SMdoi
10.1016/s0006-3223(97)00551-9subject
Has Abstractpub_date
1998-07-01 00:00:00pages
21-33issue
1eissn
0006-3223issn
1873-2402pii
S0006-3223(97)00551-9journal_volume
44pub_type
临床试验,杂志文章abstract::The purpose of this study was to evaluate blood magnesium (Mg) measures across the menstrual cycle in women with premenstrual syndrome (PMS) and control women. Longitudinal determinations of plasma, red blood cell (RBC) and mononuclear blood cell (MBC) Mg were made in 26 women with prospectively confirmed PMS and in a...
journal_title:Biological psychiatry
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doi:10.1016/0006-3223(94)90103-1
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abstract::Heterogeneity is a major obstacle in the search for biological substrates in schizophrenia. The positive and negative distinction, even if too simplistic, may improve our understanding of underlying processes. Frontostriatal deficits have been related to negative symptoms, while dysfunction of the dominant temporal lo...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/0006-3223(94)00205-H
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pub_type: 杂志文章,评审
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:
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journal_title:Biological psychiatry
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doi:10.1016/s0006-3223(99)00026-8
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doi:10.1016/j.biopsych.2019.09.023
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pub_type: 杂志文章
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journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/0006-3223(90)90591-o
更新日期:1990-04-01 00:00:00
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pub_type: 杂志文章
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doi:10.1016/0006-3223(89)90117-0
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(88)90022-4
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(94)00238-X
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doi:10.1016/0006-3223(92)90040-7
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(94)91214-9
更新日期:1994-09-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01115-5
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(95)00048-8
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1016/0006-3223(86)90006-5
更新日期:1986-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(89)90053-x
更新日期:1989-08-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(89)90160-1
更新日期:1989-01-15 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2007.01.004
更新日期:2008-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90008-n
更新日期:1992-01-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.02.006
更新日期:2008-09-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(97)00522-2
更新日期:1998-11-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
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journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2010.08.028
更新日期:2011-04-01 00:00:00