Cerebrospinal fluid probenecid studies: a reinterpretation.

abstract：:The involvement of the dopamine (DA) innervation of the medial prefrontal cortex (PFC) in attention was studied in a latent inhibition (LI) paradigm in rats. LI becomes evident by a retardation of conditioning to a stimulus after nonreinforced preexposure to that stimulus. LI is thought to reflect an animal's ability ...

journal_title：Biological psychiatry

authors： Broersen LM,Heinsbroek RP,de Bruin JP,Olivier B

更新日期：1996-12-01 00:00:00

abstract：:Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma rat...

journal_title：Biological psychiatry

authors： Branchey L,Branchey M,Worner TM,Zucker D,Shaw S,Lieber CS

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to describe the distribution of regional cerebral blood flow during the hypnotic state (HS) in humans, using positron-emission tomography (PET) and statistical parametric mapping. METHODS:The hypnotic state relied on revivification of pleasant autobiographical memories and w...

journal_title：Biological psychiatry

authors： Maquet P,Faymonville ME,Degueldre C,Delfiore G,Franck G,Luxen A,Lamy M

更新日期：1999-02-01 00:00:00

abstract：:Previous studies have demonstrated blunted beta-adrenergic responsivity in leukocytes from depressed patients. We sought to determine if this blunted cyclic adenosine monophosphate (AMP) response is specific for beta-adrenergic receptors (homologous), or whether other adenylyl cyclase-coupled receptors are also involv...

journal_title：Biological psychiatry

authors： Mann JJ,Halper JP,Wilner PJ,Sweeney JA,Mieczkowski TA,Chen JS,Stokes PE,Brown RP

更新日期：1997-11-15 00:00:00

abstract：BACKGROUND:Children with early-onset disruptive behavior disorder (DBD), especially those with callous-unemotional traits, are at risk of developing persistent and severe adult antisocial behavior. One possible underlying mechanism for persistence is deficient reward and loss sensitivity, i.e., deficient incentive proc...

journal_title：Biological psychiatry

authors： Cohn MD,Veltman DJ,Pape LE,van Lith K,Vermeiren RR,van den Brink W,Doreleijers TA,Popma A

更新日期：2015-11-01 00:00:00

abstract：:Psychiatric disorders show high rates of comorbidity and nonspecificity of presenting clinical symptoms, while demonstrating substantial heterogeneity within diagnostic categories. Notably, many of these psychiatric disorders first manifest in youth. We review progress and next steps in efforts to parse heterogeneity ...

journal_title：Biological psychiatry

authors： Kaczkurkin AN,Moore TM,Sotiras A,Xia CH,Shinohara RT,Satterthwaite TD

更新日期：2020-07-01 00:00:00

abstract：:The evidence that catecholestrogens are formed in the brain and exert behavioral effects in animal models suggest that these steroids might have psychotropic activities. In the present investigation, the formation and metabolism of catecholestrogens were studied in depressed patients. Twenty-four-hr urine samples were...

journal_title：Biological psychiatry

authors： Banger M,Hiemke C,Knuppen R,Ball P,Haupt M,Wiedemann K

更新日期：1990-10-15 00:00:00

abstract：BACKGROUND:Ovarian steroids modulate anxiety behavior, perhaps by regulating the serotonergic neurons in the midbrain raphe nucleus. The regulation of the brain-specific isoform of rat tryptophan hydroxylase (TPH2) by ovarian hormones has not yet been investigated. Therefore, we examined the effects of estrogen and pro...

journal_title：Biological psychiatry

authors： Hiroi R,McDevitt RA,Neumaier JF

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...

journal_title：Biological psychiatry

authors： Ranganathan M,Cortes-Briones J,Radhakrishnan R,Thurnauer H,Planeta B,Skosnik P,Gao H,Labaree D,Neumeister A,Pittman B,Surti T,Huang Y,Carson RE,D'Souza DC

更新日期：2016-06-15 00:00:00

abstract：:The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a sign...

journal_title：Biological psychiatry

authors： Rosen J,Silk KR,Rice HE,Smith CB

更新日期：1985-05-01 00:00:00

abstract：:Smooth pursuit eye movements (SPEM) for two stimulus velocities (sinusoidal and triangular) were studied by visual inspection in 12 unmedicated RDC-diagnosed schizophrenic patients and in 13 matched controls. SPEM was worse in the patient group and their performance deteriorated with repeated presentations of the task...

journal_title：Biological psychiatry

authors： Bartfai A,Levander SE,Sedvall G

更新日期：1983-09-01 00:00:00

abstract：:The uptake of L-tryptophan by chicken erythrocytes is stimulated by the presence of human plasma; however, there is no difference between the stimulation caused by plasmas of normal, chronic hospitalized nonschizophrenic, or chronic hospitalized schizophrenic subjects. Human plasma in general contains a complement-dep...

journal_title：Biological psychiatry

authors： Guchhait RB,Janson C,Price WH

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:Previous magnetic resonance imaging (MRI) studies indicate that compared with healthy volunteers, patients with bipolar disorder have structural and functional abnormalities in the prefrontal cortex. The aim of this study was to investigate differences in prefrontal subregions between bipolar patients and he...

journal_title：Biological psychiatry

authors： López-Larson MP,DelBello MP,Zimmerman ME,Schwiers ML,Strakowski SM

更新日期：2002-07-15 00:00:00

abstract：BACKGROUND:Bipolar disorder is associated with functional and structural abnormalities in the brain circuits involved in processing emotional stimuli. Although impairments of cognitive function have been found to persist in bipolar patients during periods of euthymic mood, it is not known whether abnormalities in emoti...

journal_title：Biological psychiatry

authors： Harmer CJ,Grayson L,Goodwin GM

更新日期：2002-02-15 00:00:00

abstract：BACKGROUND:Corticotropin-releasing hormone (CRH) hyperactivity in transgenic mice overexpressing CRH in the brain (CRH-OE(2122)) appears to be associated with chronic stress-like alterations, including increased CRH content in the hypothalamus, changes in hypothalamus-pituitary-adrenal axis regulation, and increased he...

journal_title：Biological psychiatry

authors： Dirks A,Groenink L,Schipholt MI,van der Gugten J,Hijzen TH,Geyer MA,Olivier B

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role in maintaining dendritic structure through its interaction with microtubules. In schizophrenia (Sz), numerous studies have revealed that the typically robust immunoreactivity (IR) of MAP2 is significantly reduced across several c...

journal_title：Biological psychiatry

authors： Shelton MA,Newman JT,Gu H,Sampson AR,Fish KN,MacDonald ML,Moyer CE,DiBitetto JV,Dorph-Petersen KA,Penzes P,Lewis DA,Sweet RA

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:A novel, high-affinity (.7-2.0 nmol) compound that selectively activates the alpha2, alpha 3, and alpha 5 (but not alpha1) gamma-aminobutyric acid-A (GABA(A)) receptor subtypes, TPA023B (2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl) imidazo[1,2-b][1,2,4]triazin-7-yl][1,1'-biphenyl]-2-carbonitrile) was pharma...

journal_title：Biological psychiatry

authors： Van Laere K,Bormans G,Sanabria-Bohórquez SM,de Groot T,Dupont P,De Lepeleire I,de Hoon J,Mortelmans L,Hargreaves RJ,Atack JR,Burns HD

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:There is a paucity of neuroimaging data in pediatric-onset obsessive-compulsive disorder (OCD). This multimodal neuroimaging study aimed to identify structural gray (GM) and white matter (WM) microstructure changes in pediatric OCD. METHODS:We obtained structural and diffusion tensor magnetic resonance imag...

journal_title：Biological psychiatry

authors： Zarei M,Mataix-Cols D,Heyman I,Hough M,Doherty J,Burge L,Winmill L,Nijhawan S,Matthews PM,James A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS:We studied young individuals with at least two relatives with the di...

journal_title：Biological psychiatry

authors： Whalley HC,Simonotto E,Moorhead W,McIntosh A,Marshall I,Ebmeier KP,Owens DG,Goddard NH,Johnstone EC,Lawrie SM

更新日期：2006-09-01 00:00:00

abstract：:The possibility of characterizing subgroups of depressive disorders by biological markers was studied by means of the dexamethasone suppression test (DST), the 24-hr urinary free cortisol (UFC), the growth hormone response to the insulin tolerance test (ITT), and polygraphic sleep recordings. Forty-five hospitalized p...

journal_title：Biological psychiatry

authors： Berger M,Doerr P,Lund R,Bronisch T,von Zerssen D

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Patients with autism show clinical features suggestive of abnormal processing of auditory and other sensory information. We hypothesized that low-functioning autistic subjects present abnormalities in discriminating simple auditory stimuli at sensory system preconscious stages of cortical processing. METHOD...

journal_title：Biological psychiatry

authors： Tecchio F,Benassi F,Zappasodi F,Gialloreti LE,Palermo M,Seri S,Rossini PM

更新日期：2003-09-15 00:00:00

abstract：BACKGROUND:Studies in elderly patients demonstrate antipsychotic efficacy and favorable safety profiles for olanzapine. We report results from two placebo-controlled, double-blind studies of olanzapine for treatment of dopamimetic drug-induced psychosis in patients with Parkinson's disease (PD). METHODS:Patients were ...

journal_title：Biological psychiatry

authors： Breier A,Sutton VK,Feldman PD,Kadam DL,Ferchland I,Wright P,Friedman JH

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Postmortem studies examining discrete regions show reduced cortical thickness in schizophrenia. Computational image analysis methods allow spatially detailed cortical thickness measurements across the entire cortex in 3D, but have not addressed thickness changes in cingulate or other cortices bordering the m...

journal_title：Biological psychiatry

authors： Narr KL,Toga AW,Szeszko P,Thompson PM,Woods RP,Robinson D,Sevy S,Wang Y,Schrock K,Bilder RM

更新日期：2005-07-01 00:00:00

abstract：:Cannabis use has been reported to increase the risk of developing schizophrenia and to worsen symptoms of the illness. Both of these outcomes might be attributable to the disruption by cannabis of the endogenous cannabinoid system's spatiotemporal regulation of the inhibitory circuitry in the prefrontal cortex that is...

journal_title：Biological psychiatry

authors： Volk DW,Lewis DA

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Noradrenergic function has been linked to posttraumatic stress disorder (PTSD) and might have a role in mediating sleep disturbances of the disorder. Our objective was to relate a peripheral manifestation of noradrenergic function, sympathetic nervous system activity as indexed by heart rate variability duri...

journal_title：Biological psychiatry

authors： Mellman TA,Knorr BR,Pigeon WR,Leiter JC,Akay M

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety. Within the 5-HT1A receptor gene, a powerful dual repressor element (DRE) is regulated ...

journal_title：Biological psychiatry

authors： Hadjighassem MR,Austin MC,Szewczyk B,Daigle M,Stockmeier CA,Albert PR

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Previous studies demonstrate that indirect activation of monoamine receptors by antidepressant treatment increases neurotrophic factors that activate the mitogen-activated protein kinase cascade; however, it is also possible that these monoamine receptors influence the mitogen-activated protein kinase pathwa...

journal_title：Biological psychiatry

authors： Tolbert LM,Russell DS,Duman RS

更新日期：2003-11-15 00:00:00

abstract：:Recall of dichotically presented digit strings was compared between normal controls and 18 chronic schizophrenic patients tested over 12 weeks on chlorpromazine, placebo, and chlorpromazine reinstatement. Patients were subgrouped according to (i) arousal as indexed by orienting responses in a tone-habituation sequence...

journal_title：Biological psychiatry

authors： Gruzelier JH,Hammond NV

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:This study assessed whether reduced regional cerebral blood flow (rCBF; hypoperfusion) in cocaine-dependent (CD) patients is associated with platelet abnormalities and whether these platelet abnormalities predict improvement in hypoperfusion after 1 month of abstinence. METHODS:We correlated platelet number...

journal_title：Biological psychiatry

authors： Kosten TR,Tucker K,Gottschalk PC,Rinder CS,Rinder HM

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Myotonic dystrophy (DM) is a genetic multisystemic disease with muscular, endocrine, ocular, cardiac and cognitive impairment. The molecular basis of the disease has been identified in an unstable base triplet (CTG)n repeat located in the 3' untranslated region of the miotonin protein-kinase (MT-PK) gene on ...

journal_title：Biological psychiatry

authors： Perini GI,Menegazzo E,Ermani M,Zara M,Gemma A,Ferruzza E,Gennarelli M,Angelini C

更新日期：1999-08-01 00:00:00