Abstract:
:Unmedicated chronic schizophrenic inpatients and nonpsychotic controls were tested in a paradigm designed to elicit habituated event-related potentials (ERPs) to auditory stimuli. Analysis of Variance of the ERP components recorded at bilateral frontal (F1 and F2) and temporal (T3 and T4) scalp leads revealed significant decreases in N1 component amplitudes in both frontal leads in the schizophrenic subjects. P2 and N2 amplitudes also tended to be smaller at frontal leads in the schizophrenic subjects, but these differences were not found to be statistically significant overall. The schizophrenic subjects were assigned to diagnostic subgroups following administration of the Diagnostic Interview Schedule, the Maine Paranoid Scale, and the Scale for the Assessment of Negative Symptoms. Subjects meeting DSM-III criteria for paranoid schizophrenia were assigned to one subgroup (PS subgroup), and those meeting DSM-III criteria for residual or undifferentiated schizophrenia were assigned to another subgroup (RS subgroup). The Analysis of Variance of the N1 amplitude measures was repeated with subgroup diagnosis as a factor, revealing significant decreases in N1 amplitude in the PS, but not the RS, patients. Patients in the PS subgroup were found to differ significantly from those in the RS subgroup on this ERP measure, as well as from controls. These results suggest that subgroup differences exist within the schizophrenic population that are reflected in differential changes in ERP morphology.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Kessler C,Steinberg Adoi
10.1016/0006-3223(89)90053-xsubject
Has Abstractpub_date
1989-08-01 00:00:00pages
372-80issue
4eissn
0006-3223issn
1873-2402pii
0006-3223(89)90053-Xjournal_volume
26pub_type
杂志文章abstract:BACKGROUND:Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness. METHODS:Cerebrospinal fluid (CSF) levels of the excitatory amino acids glutamate (Glu) and aspartate (Asp) and the N-methyl-D-aspartate (NMDA) receptor modulator, glycine (GLY) were ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.01.024
更新日期:2007-01-15 00:00:00
abstract::In four series of studies on schizophrenic patients and normals we found that all the schizophrenics eliminated N, N-dimethyltryptamines in their urine while none of the normals did so. Similarly, with early infantile autism (Studies I and II) and normal controls, this separation between patiens and normals still held...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract::Animal studies indicate that seizures can be produced reliably with a fraction of the electrical energy now required by currently available electroconvulsive therapy (ECT) instruments. This may result in further reduction of the side effects of ECT. The stimulus energy does not necessarily correspond to the energy dep...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(85)90098-8
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Recent studies have suggested that there may be a preferential decrease of "nonpyramidal" neurons (NPs) in several corticolimbic regions of schizophrenic (SZ) brain. The current study was undertaken to determine whether a change in the density of pyramidal neurons (PNs) and NPs might be present in the hippoc...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00138-3
更新日期:1998-07-15 00:00:00
abstract::Mutations in mitochondrial DNA (mtDNA) are implicated in the pathophysiology of affective disorders. To determine whether the 4977-base-pair deletion in mtDNA is more frequent in affective disorders, we quantitated the concentration of this deletion in leukocyte mtDNA in 34 probands with affective disorders (20 bipola...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/S0006-3223(96)00377-0
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Alcohol and tobacco dependence are highly comorbid disorders, with preclinical evidence suggesting a role for nicotinic acetylcholine receptors (nAChRs) in alcohol consumption. Varenicline, a partial nicotinic agonist with high affinity for the alpha4beta2 nAChR receptor, reduced ethanol intake in rodents. W...
journal_title:Biological psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.biopsych.2009.01.029
更新日期:2009-07-15 00:00:00
abstract:BACKGROUND:Neurons containing proopiomelanocortin (POMC)-derived peptides, known to control stress axis, metabolic, and immune functions, have a lower function in patients with a family history of alcoholism, raising the possibility that alcohol effects on the POMC system may transmit through generations. Here we descr...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.04.006
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Children with early-onset disruptive behavior disorder (DBD), especially those with callous-unemotional traits, are at risk of developing persistent and severe adult antisocial behavior. One possible underlying mechanism for persistence is deficient reward and loss sensitivity, i.e., deficient incentive proc...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2014.08.017
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Positron emission tomography studies have demonstrated less dopamine D2/3 receptor availability and blunted psychostimulant-induced dopamine release in cocaine-dependent subjects (CDSs). No studies in CDSs have reported the in vivo status of D2/3 and dopamine release in the cortex. Basic and functional imagi...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2020.04.001
更新日期:2020-11-15 00:00:00
abstract:BACKGROUND:Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability, and predictors of mood and anxiety diso...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.07.015
更新日期:2016-05-15 00:00:00
abstract:BACKGROUND:Elevated endogenous levels of corticosteroids cause neural dysfunction and loss, especially within the hippocampus, as well as cognitive impairment in hippocampus-mediated tasks. Because Cushing's syndrome patients suffer from hypercortisolism, they represent a unique opportunity to study the impact of eleva...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.09.003
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological systems (e.g., inflammation, oxidative stress) and induces peripher...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.02.006
更新日期:2019-06-15 00:00:00
abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) is a noninvasive procedure that may be used to study individual differences in motor cortex excitability. Such differences are assumed to reflect serotonergic and other inputs to the motor cortex. METHODS:Here we investigate the impact of a functional polymorphism in ...
journal_title:Biological psychiatry
pub_type: 杂志文章,收录出版
doi:10.1016/j.biopsych.2009.02.005
更新日期:2009-08-01 00:00:00
abstract::Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been reported in several studies. The G72/G30 locus may be one of several that account for the evidence of linkage that spans a broad region of chromosome 13q. However, the story of G72/G30 is complex. Our meta-analysis of published assoc...
journal_title:Biological psychiatry
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.biopsych.2006.01.019
更新日期:2006-07-15 00:00:00
abstract::Abnormal adrenocortical regulation has been reported in patients with endogenous depression, including excessive cortisol production with loss of circadian periodicity and decreased suppression by dexamethasone. The inhibitory effect of the neurotransmitter norepinephrine (NE) on the hypothalamic-pituitary adrenal (HP...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::The pharmacokinetics of dexamethasone (DEX) were studied in 9 drug-free melancholically depressed patients and 10 healthy control subjects matched by sex and age. Each subject received 1 mg of DEX administered orally and by the (i.v.) route at 11:00 PM and serial blood samples were collected over the next 17 hours unt...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/s0006-3223(96)00094-7
更新日期:1997-03-01 00:00:00
abstract::This study shows that chronic, long-hospitalized schizophrenics perform (tested by the Famous Events Questionnaire) at a higher level on remote memory than they do on word list recall. A post hoc, matched-tasks check suggested that this finding was not due to differences in the discriminating power of the tasks. Relat...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(87)90133-8
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The current effective treatment options for posttraumatic stress disorder (PTSD) are limited, and therefore the need to explore new treatment strategies is critical. Pharmacological inhibition of the renin-angiotensin system is a common approach to treat hypertension, and emerging evidence highlights the imp...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.08.024
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Reduction in a pre-attentive measure of auditory change detection, mismatch negativity (MMN), is one of the most consistent findings in schizophrenia. Recently, our group showed a reduction in MMN to changes in the duration and intensity of background sounds in those within 5 years of illness onset, whereas ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2011.08.023
更新日期:2012-01-15 00:00:00
abstract::Despite recognition that schizophrenia must have syndrome status in the absence of proof of a single etiopathophysiologic process, a century of work has been based on designs that conceptualize schizophrenia as a single disease entity. Reducing heterogeneity at several levels of functioning is desirable. In this artic...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(99)00088-8
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antidepressant...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2003.12.016
更新日期:2004-04-15 00:00:00
abstract::We have investigated the dexamethasone suppression of cortisol release in a group of 28 patients with senile dementia of the Alzheimer type (SDAT) after stimulation by physostigmine and clonidine, as compared with basal conditions. All patients but one had previously been evaluated with a depression symptom checklist ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(88)90102-3
更新日期:1988-01-01 00:00:00
abstract::The locus coeruleus (LC) is the major noradrenergic nucleus in the brain and innervates large segments of the neuraxis. LC neurons are thought to regulate states of attention and vigilance as well as activity of the sympathetic nervous system. These neurons also have been implicated in the actions of stress, antidepre...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(99)00158-4
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy. METHODS:This 10-week, acute, randomized, controlled, masked trial compared adjunc...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.biopsych.2005.05.025
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Major depressive disorder is associated with disturbed circadian rhythms. To investigate the causal relationship between mood disorders and circadian clock disruption, previous studies in animal models have employed light/dark manipulations, global mutations of clock genes, or brain area lesions. However, li...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2016.03.1050
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across ma...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.02.017
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Conflicting findings have emerged from studies examining the impact of depression on death and readmission following a coronary event, possibly reflecting differences in the measurement of "depression" and the onset of depression in relation to the coronary event. The aim of this study was to examine the rel...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.05.021
更新日期:2008-10-15 00:00:00
abstract:BACKGROUND:We recently described a preliminary association between the hypofunctional seven-repeat allele of the dopamine-4 receptor gene (DRD4) and increased maximal lifetime body mass index in women with seasonal affective disorder (SAD). In this study, we examined whether binge eating behavior mediated this putative...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2004.08.013
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Affective facial processing is an important component of interpersonal relationships. The neural substrate has been examined following treatment with antidepressant medication but not with psychological therapies. The present study investigated the neural correlates of implicit processing of sad facial expre...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.04.033
更新日期:2008-09-15 00:00:00
abstract::This paper discusses the current practice of using single word labels for emotional states that ignore the nature of the incentive, cognitive representations, physiologic profile, and especially the developmental stage of the agent. The universal cognitive advances that are derivatives of brain maturation over the fir...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(01)01115-5
更新日期:2001-06-15 00:00:00