Evoked potential variation in schizophrenic subgroups.


:Unmedicated chronic schizophrenic inpatients and nonpsychotic controls were tested in a paradigm designed to elicit habituated event-related potentials (ERPs) to auditory stimuli. Analysis of Variance of the ERP components recorded at bilateral frontal (F1 and F2) and temporal (T3 and T4) scalp leads revealed significant decreases in N1 component amplitudes in both frontal leads in the schizophrenic subjects. P2 and N2 amplitudes also tended to be smaller at frontal leads in the schizophrenic subjects, but these differences were not found to be statistically significant overall. The schizophrenic subjects were assigned to diagnostic subgroups following administration of the Diagnostic Interview Schedule, the Maine Paranoid Scale, and the Scale for the Assessment of Negative Symptoms. Subjects meeting DSM-III criteria for paranoid schizophrenia were assigned to one subgroup (PS subgroup), and those meeting DSM-III criteria for residual or undifferentiated schizophrenia were assigned to another subgroup (RS subgroup). The Analysis of Variance of the N1 amplitude measures was repeated with subgroup diagnosis as a factor, revealing significant decreases in N1 amplitude in the PS, but not the RS, patients. Patients in the PS subgroup were found to differ significantly from those in the RS subgroup on this ERP measure, as well as from controls. These results suggest that subgroup differences exist within the schizophrenic population that are reflected in differential changes in ERP morphology.


Biol Psychiatry


Biological psychiatry


Kessler C,Steinberg A




Has Abstract


1989-08-01 00:00:00














  • Antipsychotic drugs and plasma vasopressin in normals and acute schizophrenic patients.

    abstract::Elevated plasma vasopressin concentrations have been documented in antipsychotic drug-treated patients as well as a drug-free acutely psychotic patients. To evaluate the effects of antipsychotic drugs on plasma vasopressin, we measured vasopressin response to a single dose of intramuscular chlorpromazine or intravenou...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Raskind MA,Courtney N,Murburg MM,Backus FI,Bokan JA,Ries RK,Dorsa DM,Weitzman RE

    更新日期:1987-04-01 00:00:00

  • The benzodiazepine antagonist Ro 15-1788 does not antagonize the ethanol withdrawal syndrome.

    abstract::It has been suggested that the signs and symptoms of the ethanol withdrawal syndrome may be due to the increased production of an "inverse agonist" that binds to the central benzodiazepine (BZ) recognition site in the brain. Ro 15-1788 (a potent antagonist at the central BZ recognition site), diazepam, and Ro 15-1788 ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Adinoff B,Majchrowicz E,Martin PR,Linnoila M

    更新日期:1986-06-01 00:00:00

  • Histochemical changes in the blood cells of schizophrenic patients under pimozide treatment.

    abstract::Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal dis...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Stefanis CN,Issidorides MR

    更新日期:1976-02-01 00:00:00

  • Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive disorders.

    abstract::The dexamethasone suppression test (DST) and sleep EEG were compared in three different descriptive diagnostic schemes in 70 adult patients with nonpsychotic, unipolar major depressive disorder according to Research Diagnostic Criteria. Endogenous (E)/nonendogenous (NE), primary/secondary, and Winokur's family history...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Rush AJ,Giles DE,Roffwarg HP,Parker CR

    更新日期:1982-03-01 00:00:00

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    abstract:BACKGROUND:Fragile X syndrome (FXS) is the most common known heritable cause of intellectual disability. Prior studies in FXS have observed a plateau in cognitive and adaptive behavioral development in early adolescence, suggesting that brain development in FXS may diverge from typical development during this period. ...

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    authors: Bray S,Hirt M,Jo B,Hall SS,Lightbody AA,Walter E,Chen K,Patnaik S,Reiss AL

    更新日期:2011-11-01 00:00:00

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    abstract:BACKGROUND:Pathogenic mutations in the X-linked Neuroligin 4 gene (NLGN4X) in autism spectrum disorders (ASDs) and/or mental retardation (MR) are rare. However, nothing is known regarding a possible altered expression level of NLGN4X that would be caused by mutations in regulatory sequences. We investigated this issue ...

    journal_title:Biological psychiatry

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    authors: Daoud H,Bonnet-Brilhault F,Védrine S,Demattéi MV,Vourc'h P,Bayou N,Andres CR,Barthélémy C,Laumonnier F,Briault S

    更新日期:2009-11-15 00:00:00

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    authors: Maes M,Lin AH,Delmeire L,Van Gastel A,Kenis G,De Jongh R,Bosmans E

    更新日期:1999-04-01 00:00:00

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    更新日期:2016-05-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


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    更新日期:2003-05-15 00:00:00

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    authors: Brettschneider S,Morgenthaler NG,Teipel SJ,Fischer-Schulz C,Bürger K,Dodel R,Du Y,Möller HJ,Bergmann A,Hampel H

    更新日期:2005-04-01 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章,meta分析


    authors: Lefebvre A,Beggiato A,Bourgeron T,Toro R

    更新日期:2015-07-15 00:00:00

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    pub_type: 杂志文章


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    更新日期:2003-03-01 00:00:00

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    pub_type: 临床试验,杂志文章


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    更新日期:1998-09-15 00:00:00

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    pub_type: 杂志文章


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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Banki CM,Karmacsi L,Bissette G,Nemeroff CB

    更新日期:1992-09-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2019-06-15 00:00:00

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Nagamoto HT,Adler LE,Waldo MC,Freedman R

    更新日期:1989-03-01 00:00:00

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    abstract:BACKGROUND:Down syndrome (DS) is a genetic disorder (trisomy 21 in 96% of cases), associated with an excess of a key enzyme involved with free radical metabolism (FRM), superoxide dismutase-1 (SOD-1), that is encoded by a gene on chromosome 21. Consequently, SOD-1 activity is elevated in DS, which also occurs in condit...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Brugge K,Nichols S,Saitoh T,Trauner D

    更新日期:1999-12-15 00:00:00

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    abstract:BACKGROUND:Brainstem auditory evoked potentials (BAEP) reflect the activation of brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These electrophysiological correlates of neural processing are highly automatic and not influenced by cognitive factors or task demands; however, data f...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Baas JM,Milstein J,Donlevy M,Grillon C

    更新日期:2006-04-01 00:00:00

  • Markers of Psychosis Risk in the General Population.

    abstract::The categorical approach to defining schizophrenia spectrum disorders requires meeting established criteria. To advance early identification and intervention in young people, the field has progressed to studying help-seeking individuals who are at clinical high risk based on subthreshold psychosis spectrum symptoms, a...

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    pub_type: 杂志文章,评审


    authors: Taylor JH,Calkins ME,Gur RE

    更新日期:2020-08-15 00:00:00

  • Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization.

    abstract:BACKGROUND:Amphetamine administration induces stimulation-independent dopamine release in the nucleus accumbens (NAcc) through reverse dopamine transport, a critical neurochemical event involved in its psychostimulant action, and furthermore decreases stimulation-dependent vesicular dopamine release. These effects may ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: David HN,Ansseau M,Lemaire M,Abraini JH

    更新日期:2006-07-01 00:00:00

  • Neurobiology of emotion perception II: Implications for major psychiatric disorders.

    abstract::To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for ...

    journal_title:Biological psychiatry

    pub_type: 杂志文章,评审


    authors: Phillips ML,Drevets WC,Rauch SL,Lane R

    更新日期:2003-09-01 00:00:00

  • Patients with premenstrual syndrome have decreased saccadic eye velocity compared to control subjects.

    abstract:BACKGROUND:Prior neurophysiological studies on patients with premenstrual syndrome (PMS) have revealed sleep electroencephalographic alterations in both cycle phases. We report on a study evaluating saccadic eye movements in PMS patients. METHODS:Saccadic eye movements were examined in 21 women with and 21 women witho...

    journal_title:Biological psychiatry

    pub_type: 临床试验,杂志文章


    authors: Sundström I,Bäckström T

    更新日期:1998-10-15 00:00:00

  • Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation.

    abstract:BACKGROUND:A polymorphism of the human serotonin transporter gene (SCL6A4) has been associated with serotonin transporter expression and with processing of aversive stimuli in the amygdala. Functional imaging studies show that during the presentation of aversive versus neutral cues, healthy carriers of the short (s) al...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Heinz A,Smolka MN,Braus DF,Wrase J,Beck A,Flor H,Mann K,Schumann G,Büchel C,Hariri AR,Weinberger DR

    更新日期:2007-04-15 00:00:00

  • Formation and metabolism of catecholestrogens in depressed patients.

    abstract::The evidence that catecholestrogens are formed in the brain and exert behavioral effects in animal models suggest that these steroids might have psychotropic activities. In the present investigation, the formation and metabolism of catecholestrogens were studied in depressed patients. Twenty-four-hr urine samples were...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Banger M,Hiemke C,Knuppen R,Ball P,Haupt M,Wiedemann K

    更新日期:1990-10-15 00:00:00

  • Association of the APOE epsilon 4 allele with clinical subtypes of late life depression.

    abstract::The APOE genotypes of 45 elderly inpatients with major depression were determined to investigate the relationship of this disorder to irreversible dementia in late life. We specifically tested the hypothesis that the frequency of the APOE epsilon 4 allele is elevated in depressed elders with cognitive impairment or ps...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Zubenko GS,Henderson R,Stiffler JS,Stabler S,Rosen J,Kaplan BB

    更新日期:1996-11-15 00:00:00

  • A Pattern of Cognitive Deficits Stratified for Genetic and Environmental Risk Reliably Classifies Patients With Schizophrenia From Healthy Control Subjects.

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    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Antonucci LA,Pergola G,Pigoni A,Dwyer D,Kambeitz-Ilankovic L,Penzel N,Romano R,Gelao B,Torretta S,Rampino A,Trojano M,Caforio G,Falkai P,Blasi G,Koutsouleris N,Bertolino A

    更新日期:2020-04-15 00:00:00

  • Predictors of the course of tardive dyskinesia in patients receiving neuroleptics.

    abstract::As many patients still require maintenance neuroleptic medication, it is important to determine what factors affect the course of tardive dyskinesia (TD) during ongoing neuroleptic treatment. In this study the data are from a series of annual examinations using the Abnormal Involuntary Movement Scale (AIMS) in a cohor...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Bergen J,Kitchin R,Berry G

    更新日期:1992-10-01 00:00:00

  • A study of relationships of serum glucose, insulin, free fatty acids, and free and total tryptophan to mental illness.

    abstract::To explore possible disturbances of cerebral monoamines linked to glucose metabolism, 18 schizophrenics, 21 neurotics, and 21 controls were given a 5-hr glucose tolerance test, and the effect of the glucose load on total and free tryptophan, insulin, and free fatty acids in serum was studied in medication-free patient...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Yaryura-Tobias JA,Chang A,Neziroglu F

    更新日期:1978-04-01 00:00:00

  • Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy.

    abstract:BACKGROUND:Metabolic changes after electroconvulsive therapy (ECT) have been described in depressed patients, but results are heterogeneous. To determine the concentrations of N-acetyl-aspartate (NAA), choline-containing compounds, creatine + phosphocreatine (tCr), and glutamate in the left dorsolateral prefrontal cort...

    journal_title:Biological psychiatry

    pub_type: 杂志文章


    authors: Merkl A,Schubert F,Quante A,Luborzewski A,Brakemeier EL,Grimm S,Heuser I,Bajbouj M

    更新日期:2011-04-15 00:00:00