Abstract：
BACKGROUND:Volumetric imaging research has shown abnormal brain morphology in adults with posttraumatic stress disorder (PTSD) when compared with matched control subjects. In this article, we present brain imaging findings from a study of children with PTSD symptoms. METHODS:Twenty-four children between the ages of 7 and 14 with a history of trauma and PTSD symptoms were assessed with the Clinician-Administered PTSD Scale for Children and Adolescents (CAPS-CA). The sample underwent magnetic resonance imaging in a 1.5 T scanner. Brain images were analyzed by raters blind to diagnostic status using well-standardized methods, and images were compared with age- and gender-matched healthy control subjects. RESULTS:The clinical group demonstrated attenuation of frontal lobe asymmetry and smaller total brain and cerebral volumes when compared with the control group. There were no statistically significant differences in hippocampal volume between clinical and control subjects. CONCLUSIONS:Frontal lobe abnormalities may occur as a result of PTSD in children or, alternatively, be a risk factor for the development of the syndrome in this age group. The implications of the findings and their consistency with previous research are discussed.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Carrion VG,Weems CF,Eliez S,Patwardhan A,Brown W,Ray RD,Reiss ALdoi
10.1016/s0006-3223(01)01218-5subject
Has Abstractpub_date
2001-12-15 00:00:00pages
943-51issue
12eissn
0006-3223issn
1873-2402pii
S0006322301012185journal_volume
50pub_type
杂志文章abstract：:Lithium-treated and drug-free individuals were each given 0.5 mg epinephrine subcutaneously and blood samples withdrawn for measurement of plasma cyclic AMP and cyclic GMP. The rise in plasma cyclic GMP in response to epinephrine was found to be partially inhibited by lithium treatment, and previous reports of lithium...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1980-02-01 00:00:00
abstract：:The behavioral effects of a 2 mg/kg iv bolus infusion of naloxone were compared with a placebo infusion using a double-blind design in a small group of inpatient depressives (n = 6) and normals (n = 8). Naloxone produced consistent and significant worsening in the rated signs and subjective symptoms of depression in t...
journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：
更新日期：1984-06-01 00:00:00
abstract：:The preattentive automatic processing of 63 alcoholics and 27 controls was evaluated with an auditory inattentive event-related oddball paradigm. We examined the mismatch negativity and the N2-P3 complex. Results showed significantly greater amplitude for N2, P3 and the N2-P3 complex for controls but no individual lea...
journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(93)90097-w
更新日期：1993-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90091-y
更新日期：1991-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
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更新日期：2008-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-02-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00223-5
更新日期：1996-05-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsych.2014.05.018
更新日期：2015-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(95)00106-9
更新日期：1996-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2009.01.001
更新日期：2009-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-08-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
doi：10.1016/j.biopsych.2015.05.017
更新日期：2016-07-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2011.10.032
更新日期：2012-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,评审
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更新日期：2002-01-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 临床试验,杂志文章
doi：10.1016/j.biopsych.2005.02.012
更新日期：2005-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90094-3
更新日期：1991-03-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2020-04-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(91)90058-t
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2007.04.023
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journal_title：Biological psychiatry
pub_type： 杂志文章,随机对照试验
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.08.013
更新日期：2004-11-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/S0006-3223(96)00179-5
更新日期：1997-04-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2017.06.033
更新日期：2017-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章,meta分析
doi：10.1016/j.biopsych.2015.02.010
更新日期：2015-07-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/0006-3223(92)90338-z
更新日期：1992-06-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
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更新日期：2020-07-16 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2006.03.059
更新日期：2006-11-15 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/s0006-3223(99)00016-5
更新日期：1999-08-01 00:00:00
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journal_title：Biological psychiatry
pub_type： 杂志文章
doi：10.1016/j.biopsych.2004.02.012
更新日期：2004-06-01 00:00:00
