当前位置： SCI文献检索 > BIOLOGICAL PSYCHIATRY期刊下所有文献 > Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function.

Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function.

Abstract：

BACKGROUND:Low doses of psychostimulants, such as methylphenidate (MPH), are widely used in the treatment of attention-deficit/hyperactivity disorder (ADHD). Surprisingly little is known about the neural mechanisms that underlie the behavioral/cognitive actions of these drugs. The prefrontal cortex (PFC) is implicated in ADHD. Moreover, dopamine (DA) and norepinephrine (NE) are important modulators of PFC-dependent cognition. To date, the actions of low-dose psychostimulants on PFC DA and NE neurotransmission are unknown. METHODS:In vivo microdialysis was used to compare the effects of low-dose MPH on NE and DA efflux within the PFC and select subcortical fields in male rats. Doses used (oral, 2.0 mg/kg; intraperitoneal, .25-1.0 mg/kg) were first determined to produce clinically relevant plasma concentrations and to facilitate both PFC-dependent attention and working memory. RESULTS:At low doses that improve PFC-dependent cognitive function and that are devoid of locomotor-activating effects, MPH substantially increases NE and DA efflux within the PFC. In contrast, outside the PFC these doses of MPH have minimal impact on NE and DA efflux. CONCLUSIONS:The current observations suggest that the therapeutic actions of low-dose psychostimulants involve the preferential activation of catecholamine neurotransmission within the PFC.

journal_name

Biol Psychiatry

journal_title

Biological psychiatry

authors

Berridge CW,Devilbiss DM,Andrzejewski ME,Arnsten AF,Kelley AE,Schmeichel B,Hamilton C,Spencer RC

doi

10.1016/j.biopsych.2006.04.022

subject

Has Abstract

pub_date

2006-11-15 00:00:00

pages

1111-20

issue

10

eissn

0006-3223

issn

1873-2402

pii

S0006-3223(06)00533-6

journal_volume

60

pub_type

杂志文章

相关文献

BIOLOGICAL PSYCHIATRY文献大全
  • Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density.

    abstract：BACKGROUND:Abnormalities of cortical neuronal organization and reductions in neuronal somal size have been reported in schizophrenia. The purpose of this investigation was to assess patterns of neuronal and glial distribution in the anterior cingulate cortex (ACC) in major depressive disorder (MDD), schizophrenia, bipo...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00114-8

    authors： Chana G,Landau S,Beasley C,Everall IP,Cotter D

    更新日期：2003-06-15 00:00:00

  • Platelet [3H]imipramine binding in patients with panic disorder.

    abstract：:[3H]imipramine binding to platelets was measured in 17 drug-free panic disorder patients and 14 healthy controls. No difference in Bmax or Kd values was found between the two groups. Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder pati...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(87)90129-6

    authors： Uhde TW,Berrettini WH,Roy-Byrne PP,Boulenger JP,Post RM

    更新日期：1987-01-01 00:00:00

  • Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.

    abstract：BACKGROUND:Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the amygdala, and hippocampus. Although the contributions of the media...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.03.007

    authors： Agustín-Pavón C,Braesicke K,Shiba Y,Santangelo AM,Mikheenko Y,Cockroft G,Asma F,Clarke H,Man MS,Roberts AC

    更新日期：2012-08-15 00:00:00

  • The thalamus and the schizophrenia phenotype: failure to replicate reduced volume.

    abstract：BACKGROUND:Thalamic abnormalities resulting in impaired attention and information processing may form a foundation for cognitive and perceptual disturbances in schizophrenia. Measurements of the thalamus in patients with schizophrenia have shown reductions relative to normal comparison subjects. METHODS:In the current...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(97)00459-9

    authors： Arciniegas D,Rojas DC,Teale P,Sheeder J,Sandberg E,Reite M

    更新日期：1999-05-15 00:00:00

  • Deficits in hippocampus-mediated Pavlovian conditioning in endogenous hypercortisolism.

    abstract：BACKGROUND:Elevated endogenous levels of corticosteroids cause neural dysfunction and loss, especially within the hippocampus, as well as cognitive impairment in hippocampus-mediated tasks. Because Cushing's syndrome patients suffer from hypercortisolism, they represent a unique opportunity to study the impact of eleva...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2004.09.003

    authors： Grillon C,Smith K,Haynos A,Nieman LK

    更新日期：2004-12-01 00:00:00

  • Hippocampal volume and mood disorders after traumatic brain injury.

    abstract：BACKGROUND:Recent evidence from clinical studies and animal models of traumatic brain injury (TBI) suggest that neuronal and glial loss might progress after the initial insult in selectively vulnerable regions of the brain such as the hippocampus. There is also evidence that hippocampal dysfunction plays a role in the ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.07.024

    authors： Jorge RE,Acion L,Starkstein SE,Magnotta V

    更新日期：2007-08-15 00:00:00

  • Biological markers in panic states: lactate-induced panic and mitral valve prolapse.

    abstract：:Anxious patients, and more specifically, patients experiencing panic attacks, are thought to have a significant biological component to their illness. This study looks at two promising biological markers associated with this patient population-mitral valve prolapse and lactate-induced panic. We present our findings, w...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(87)90152-1

    authors： Dager SR,Cowley DS,Dunner DL

    更新日期：1987-03-01 00:00:00

  • Functional imaging as a predictor of schizophrenia.

    abstract：BACKGROUND:Prospective studies of young individuals at high risk of schizophrenia allow the investigation of whether neural abnormalities predate development of illness and, if present, have the potential to identify those who may become ill. METHODS:We studied young individuals with at least two relatives with the di...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2005.11.013

    authors： Whalley HC,Simonotto E,Moorhead W,McIntosh A,Marshall I,Ebmeier KP,Owens DG,Goddard NH,Johnstone EC,Lawrie SM

    更新日期：2006-09-01 00:00:00

  • Antidepressants and periodic leg movements of sleep.

    abstract：BACKGROUND:Frequent electroencephalographic arousals or awakenings associated with periodic leg movements (PLM) might be responsible in part for the complaints of sleep disturbances made by patients treated with antidepressants. Past studies, however, have determined the effects of only certain limited antidepressants,...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.biopsych.2005.04.022

    authors： Yang C,White DP,Winkelman JW

    更新日期：2005-09-15 00:00:00

  • The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence.

    abstract：BACKGROUND:Intracellular deposition of tau protein is a hallmark lesion of Alzheimer's disease. Although it is known this event is secondary to excessive tau phosphorylation, the mechanisms involved remain unknown. We previously reported that the enzyme 5-Lipoxygenase (5LO) acts as a modulator of Aβ peptides formation ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2012.12.012

    authors： Chu J,Li JG,Ceballos-Diaz C,Golde T,Praticò D

    更新日期：2013-09-01 00:00:00

  • Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.

    abstract：BACKGROUND:Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role in maintaining dendritic structure through its interaction with microtubules. In schizophrenia (Sz), numerous studies have revealed that the typically robust immunoreactivity (IR) of MAP2 is significantly reduced across several c...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.12.029

    authors： Shelton MA,Newman JT,Gu H,Sampson AR,Fish KN,MacDonald ML,Moyer CE,DiBitetto JV,Dorph-Petersen KA,Penzes P,Lewis DA,Sweet RA

    更新日期：2015-09-15 00:00:00

  • Toxic ictal delirium.

    abstract：:Delirium, also known as acute confusional state, is a common reversible organic psychiatric syndrome. This paper focuses on toxic delirium associated with prominent paroxysmal electroencephalogram (EEG) dysfunction occurring in nonepileptic patients. Our data derive from observations in two conditions, viz., delirium ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(89)90198-4

    authors： van Sweden B,Mellerio F

    更新日期：1989-02-15 00:00:00

  • Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence.

    abstract：BACKGROUND:Intimate partner violence (IPV) is one of the most common causes of posttraumatic stress disorder (PTSD) in women. Women with IPV-related PTSD often experience comorbid chronic pain and pain-related disability. Despite the high comorbidity between PTSD and chronic pain, recent evidence suggests that male vet...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2010.03.034

    authors： Strigo IA,Simmons AN,Matthews SC,Grimes EM,Allard CB,Reinhardt LE,Paulus MP,Stein MB

    更新日期：2010-09-01 00:00:00

  • Sister chromatid exchanges and cell cycle kinetics in Alzheimer's disease.

    abstract：:Six female outpatients with Alzheimer's disease (AD) along with four female controls of a similar age range were analyzed for sister chromatid exchangers (SCEs), cell cycle kinetics, and sensitivity to mutagens, in lymphocyte cultures. The mean level of SCEs for the AD patients was 11.40 SCEs/metaphase, while that for...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Fischman HK,Reisberg B,Albu P,Ferris SH,Rainer JD

    更新日期：1984-03-01 00:00:00

  • Aversive stimuli drive drug seeking in a state of low dopamine tone.

    abstract：BACKGROUND:Stressors negatively impact emotional state and drive drug seeking, in part, by modulating the activity of the mesolimbic dopamine system. Unfortunately, the rapid regulation of dopamine signaling by the aversive stimuli that cause drug seeking is not well characterized. In a series of experiments, we scruti...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2014.09.004

    authors： Twining RC,Wheeler DS,Ebben AL,Jacobsen AJ,Robble MA,Mantsch JR,Wheeler RA

    更新日期：2015-05-15 00:00:00

  • Duration mismatch negativity and P3a in first-episode psychosis and individuals at ultra-high risk of psychosis.

    abstract：BACKGROUND:Reduction in a pre-attentive measure of auditory change detection, mismatch negativity (MMN), is one of the most consistent findings in schizophrenia. Recently, our group showed a reduction in MMN to changes in the duration and intensity of background sounds in those within 5 years of illness onset, whereas ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.08.023

    authors： Atkinson RJ,Michie PT,Schall U

    更新日期：2012-01-15 00:00:00

  • Mood and hormone responses to psychological challenge in adolescent males with conduct problems.

    abstract：BACKGROUND:Relations between stress hormones and antisocial behavior are understudied. METHODS:A subsample (n = 335) of at-risk males recruited in first grade for a longitudinal study were recruited at approximately 16 years of age for a laboratory study, including two psychological challenges: describing their worst ...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2005.01.041

    authors： McBurnett K,Raine A,Stouthamer-Loeber M,Loeber R,Kumar AM,Kumar M,Lahey BB

    更新日期：2005-05-15 00:00:00

  • Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients.

    abstract：BACKGROUND:Impaired response inhibition is a key feature of patients with alcohol dependence. Improving impulse control is a promising target for the treatment of alcohol dependence. The pharmacologic agent modafinil enhances cognitive control functions in both healthy subjects and in patients with various psychiatric ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.biopsych.2012.06.032

    authors： Schmaal L,Joos L,Koeleman M,Veltman DJ,van den Brink W,Goudriaan AE

    更新日期：2013-02-01 00:00:00

  • Differential sex-independent amygdala response to infant crying and laughing in parents versus nonparents.

    abstract：BACKGROUND:Animal and human studies implicate forebrain neural circuits in maternal behavior. Here, we hypothesized that human brain response to emotional stimuli relevant for social interactions between infants and adults are modulated by sex- and experience-dependent factors. METHODS:We used functional magnetic reso...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(03)00697-8

    authors： Seifritz E,Esposito F,Neuhoff JG,Lüthi A,Mustovic H,Dammann G,von Bardeleben U,Radue EW,Cirillo S,Tedeschi G,Di Salle F

    更新日期：2003-12-15 00:00:00

  • Clozapine-induced electroencephalogram changes as a function of clozapine serum levels.

    abstract：:Specific electroencephalogram (EEG) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/mL, 200-300 ng/mL, and 350-450 ng/mL). EEGs were obtaine...

    journal_title：Biological psychiatry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/S0006-3223(96)00298-3

    authors： Freudenreich O,Weiner RD,McEvoy JP

    更新日期：1997-07-15 00:00:00

  • Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective.

    abstract：:The history of psychiatric research is filled with widely accepted etiologic and pathophysiologic theories that eventually were proven wrong. The prevailing pathophysiologic theories of schizophrenia have emphasized the role of abnormal neurodevelopment in determining the onset and course of the illness. Relatively li...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,评审

    doi：10.1016/s0006-3223(99)00147-x

    authors： Lieberman JA

    更新日期：1999-09-15 00:00:00

  • Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia.

    abstract：BACKGROUND:Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPα, in the control of radial neuronal migration, cortical cytoarchitecture, and oligod...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2011.06.016

    authors： Takahashi N,Nielsen KS,Aleksic B,Petersen S,Ikeda M,Kushima I,Vacaresse N,Ujike H,Iwata N,Dubreuil V,Mirza N,Sakurai T,Ozaki N,Buxbaum JD,Sap J

    更新日期：2011-10-01 00:00:00

  • Reduced Brain Cannabinoid Receptor Availability in Schizophrenia.

    abstract：BACKGROUND:Several lines of evidence suggest the presence of abnormalities in the endocannabinoid (eCB) system in schizophrenia (SCZ). However, there are limited in vivo measures of the eCB system in SCZ. METHODS:Twenty five male SCZ subjects (SCZs) (18 antipsychotic treated and 7 antipsychotic free) were compared wit...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2015.08.021

    authors： Ranganathan M,Cortes-Briones J,Radhakrishnan R,Thurnauer H,Planeta B,Skosnik P,Gao H,Labaree D,Neumeister A,Pittman B,Surti T,Huang Y,Carson RE,D'Souza DC

    更新日期：2016-06-15 00:00:00

  • Tics moderate treatment outcome with sertraline but not cognitive-behavior therapy in pediatric obsessive-compulsive disorder.

    abstract：BACKGROUND:The presence of a comorbid tic disorder may predict a poorer outcome in the acute treatment of pediatric obsessive-compulsive disorder (OCD). METHODS:Using data from the National Institute of Mental Health (NIMH)-funded Pediatric OCD Treatment Study (POTS) that compared cognitive-behavior therapy (CBT), med...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2006.09.035

    authors： March JS,Franklin ME,Leonard H,Garcia A,Moore P,Freeman J,Foa E

    更新日期：2007-02-01 00:00:00

  • The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study.

    abstract：BACKGROUND:Obsessive-compulsive disorder (OCD) and tic disorders have phenomenological and familial-genetic overlaps. An OCD family study sample that excludes Tourette's syndrome in probands is used to examine whether tic disorders are part of the familial phenotype of OCD. METHODS:Eighty case and 73 control probands ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/s0006-3223(01)01074-5

    authors： Grados MA,Riddle MA,Samuels JF,Liang KY,Hoehn-Saric R,Bienvenu OJ,Walkup JT,Song D,Nestadt G

    更新日期：2001-10-15 00:00:00

  • Prospective association between C-reactive protein and fatigue in the coronary artery risk development in young adults study.

    abstract：BACKGROUND:Fatigue is highly prevalent and causes serious disruption in quality of life. Although the underlying biological mechanism is unknown, increases in inflammation have been implicated. This prospective study examined the association between C-reactive protein (CRP), a biomarker of systemic inflammation, and fa...

    journal_title：Biological psychiatry

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.biopsych.2009.06.008

    authors： Cho HJ,Seeman TE,Bower JE,Kiefe CI,Irwin MR

    更新日期：2009-11-01 00:00:00

  • Asterixis induced by carbamazepine therapy.

    abstract：:There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/0006-3223(92)90040-7

    authors： Rittmannsberger H,Leblhuber F

    更新日期：1992-08-15 00:00:00

  • Postnatal fluoxetine-evoked anxiety is prevented by concomitant 5-HT2A/C receptor blockade and mimicked by postnatal 5-HT2A/C receptor stimulation.

    abstract：BACKGROUND:Postnatal treatment with the selective serotonin reuptake inhibitor fluoxetine, evokes anxiety and depressive behavior in rodent models in adulthood. We examined the role of serotonin 2A (5-HT2A), serotonin 2C (5-HT2C) and serotonin 1A (5-HT1A) receptors, implicated in the development of anxiety, in the beha...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2013.11.005

    authors： Sarkar A,Chachra P,Vaidya VA

    更新日期：2014-12-01 00:00:00

  • A-Kinase Anchoring Protein 150 and Protein Kinase A Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress.

    abstract：BACKGROUND:The basolateral amygdala (BLA) has been widely implicated in the pathophysiology of major depressive disorder. A-kinase anchoring protein 150 (AKAP150) directs kinases and phosphatases to synaptic glutamate receptors, controlling synaptic transmission and plasticity. However, the role of the AKAP150 in the B...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：10.1016/j.biopsych.2019.03.967

    authors： Zhou HY,He JG,Hu ZL,Xue SG,Xu JF,Cui QQ,Gao SQ,Zhou B,Wu PF,Long LH,Wang F,Chen JG

    更新日期：2019-07-15 00:00:00

  • Monoamine metabolism during chronic benzodiazepine treatment and withdrawal.

    abstract：:Long-term normal-dose benzodiazepine treatment in seven patients was associated with reduced urinary excretion of MOPEG (4-hydroxy-3-methoxy-phenylglycol). Following the discontinuation of the drugs a characteristic withdrawal reaction occurred, with an increase towards normal values of the MOPEG excretion levels and ...

    journal_title：Biological psychiatry

    pub_type： 杂志文章

    doi：

    authors： Petursson H,Bond PA,Smith B,Lader MH

    更新日期：1983-02-01 00:00:00