Abstract:
:[3H]imipramine binding to platelets was measured in 17 drug-free panic disorder patients and 14 healthy controls. No difference in Bmax or Kd values was found between the two groups. Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder patients without a history of depression or severe agoraphobia.
journal_name
Biol Psychiatryjournal_title
Biological psychiatryauthors
Uhde TW,Berrettini WH,Roy-Byrne PP,Boulenger JP,Post RMdoi
10.1016/0006-3223(87)90129-6subject
Has Abstractpub_date
1987-01-01 00:00:00pages
52-8issue
1eissn
0006-3223issn
1873-2402pii
0006-3223(87)90129-6journal_volume
22pub_type
杂志文章abstract:BACKGROUND:Considering that platelets have been established to be good peripheral markers for the study of catecholaminergic neurons, we have applied an assay to measure the uptake of (3H)-dopamine (DA) into platelet storage granules (PSG). Recently, we reported that Tourette's syndrome (TS) patients (pts) show decreas...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(97)00476-9
更新日期:1998-12-01 00:00:00
abstract::The behavioral effects of a 2 mg/kg iv bolus infusion of naloxone were compared with a placebo infusion using a double-blind design in a small group of inpatient depressives (n = 6) and normals (n = 8). Naloxone produced consistent and significant worsening in the rated signs and subjective symptoms of depression in t...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract::Because recent research reports indicated clinical and biological differences in major depression with and without comorbid Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R) panic disorder, and as altered immune measures were reported in selected subgroups of depressive patients, we investigated 51 pai...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(92)90116-h
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adapt...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2016.05.025
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:The ability to stop a suboptimal response is integral to decision making and is commonly impaired across psychiatric disorders. Cortical paired associative stimulation (cPAS) is a form of transcranial magnetic stimulation in which paired pulses can induce plasticity at cortical synapses. Here we used cPAS pr...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2018.03.009
更新日期:2019-02-15 00:00:00
abstract:BACKGROUND:A deficit in sustained attention might serve as an endophenotype for schizophrenia and therefore be a useful tool in understanding the genetic underpinnings of the disorder. We sought to detail functional brain abnormalities associated with sustained attention (i.e., vigilance) in individuals with genetic li...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2005.11.017
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological systems (e.g., inflammation, oxidative stress) and induces peripher...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2019.02.006
更新日期:2019-06-15 00:00:00
abstract::Postmortem volumetry of cortex, white matter, and basal ganglia was performed in 23 brains of schizophrenic patients and 23 brains of controls closely matched for gender, age, and hemisphere. Stereological methods were applied to serial coronal sections of complete hemispheres. We found no significant volume changes o...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90091-y
更新日期:1991-03-15 00:00:00
abstract::In a sample of 13 endogenous depressive inpatients, REM (rapid eye movement) latency (recorded over 4 consecutive nights after 2 habituation nights) and contingent negative variation amplitude showed significant relationship, suggesting that both parameters may depend on the same mechanisms, possibly cholinergic. ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(85)90115-5
更新日期:1985-12-01 00:00:00
abstract::In order to evaluate the impact of aging on EEG sleep patterns we investigated the polysomnograms of 74 patients with major depression and 51 healthy volunteers aged 18-65 years. In most of the EEG sleep parameters, age-related changes were obvious in both the depressives and the normals. In the patients, some of thes...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(91)90355-p
更新日期:1991-05-15 00:00:00
abstract:BACKGROUND:This represents the first graph theory-based brain network analysis study in bipolar disorder, a chronic and disabling psychiatric disorder characterized by severe mood swings. Many imaging studies have investigated white matter in bipolar disorder, with results suggesting abnormal white matter structural in...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2012.09.014
更新日期:2013-01-15 00:00:00
abstract::Chromatin structure and nucleohistone pattern were investigated histochemically in the neutrophils of 11 schizophrenics and 16 healthy controls. Compared to controls, all schizophrenic parents prior to medication showed a distinctly different histochemical pattern consisting of increased concentration and abnormal dis...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:A central cognitive function of sleep is to consolidate newly acquired memories for long-term storage. Here, we investigated whether the overnight consolidation of declarative memory in patients with chronic sleep disturbances is impaired, owing to less slow wave sleep (SWS) and an increased cortisol release...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2006.03.051
更新日期:2006-12-15 00:00:00
abstract:BACKGROUND:We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced stress resilience are still largely unknown. METHODS:Here, we tested w...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2018.02.011
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Mounting evidence suggests that overeating may be conceptualized within the same behavioral and neurobiological framework as drug addiction. One potentially important difference between overeating versus drug abuse refers to the sensory stimulation of oral receptors by palatable foods, a feature that may be ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2013.02.028
更新日期:2013-05-01 00:00:00
abstract::Potential recovery of electrophysiological and neuropsychological functions was investigated in alcoholics completing treatment and controls. Event-related potentials (ERPs) and neuropsychological tests were administered initially and repeated 14 months later. Alcoholics were classified as resumers or abstainers based...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(94)90639-4
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Neurobiologic abnormalities in the thalamus have been implicated in the pathophysiology of obsessive-compulsive disorder. We recently reported increased thalamic volume in treatment-naive pediatric obsessive-compulsive disorder patients versus case-matched healthy comparison subjects that decreased to levels...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(00)00902-1
更新日期:2000-08-15 00:00:00
abstract::Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the fin...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2015.08.001
更新日期:2016-04-01 00:00:00
abstract::The specific binding to platelet membranes (Bmax) of 3H-clonidine, an alpha-2 agonist, and 3H-yohimbine, an alpha-2 antagonist, was measured in nine drug-free male schizophrenic patients and repeated after 2 weeks of chlorpromazine (CPZ) treatment. Patients with a lower pretreatment Bmax for 3H-clonidine showed a sign...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/0006-3223(85)90025-3
更新日期:1985-05-01 00:00:00
abstract::Buprenorphine is undergoing clinical trials for the treatment of opiate addiction. Although the abuse liability of sublingual buprenorphine is low, reports of intravenous abuse have appeared. This study describes the physiologic and subjective effects of intravenously administered buprenorphine and naloxone given alon...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/S0006-3223(96)00266-1
更新日期:1997-06-01 00:00:00
abstract::To date, there has been little investigation of the neurobiological basis of emotion processing abnormalities in psychiatric populations. We have previously discussed two neural systems: 1) a ventral system, including the amygdala, insula, ventral striatum, ventral anterior cingulate gyrus, and prefrontal cortex, for ...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/s0006-3223(03)00171-9
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Clinically and biologically, autism spectrum disorder (ASD) is heterogeneous. Unusual patterns of visual preference as indexed by eye tracking are hallmarks; however, whether they can be used to define an early biomarker of ASD as a whole or leveraged to define a subtype is unclear. To begin to examine this ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2015.03.032
更新日期:2016-04-15 00:00:00
abstract::There is no definitive neural marker of suicidal thoughts and behaviors (STBs) or nonsuicidal self-injury (NSSI), and relative to adults, research in youth is more limited. This comprehensive review focuses on magnetic resonance imaging studies reporting structural and functional neural correlates of STBs and NSSI in ...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2020.06.002
更新日期:2021-01-15 00:00:00
abstract::Converging lines of evidence suggest a role for the mesolimbic dopamine system in the response to somatic antidepressant therapies. Here, we review evidence suggesting that antidepressant treatments of different types share the effect of increasing the sensitivity of dopamine D2-like receptors in the nucleus accumbens...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2006.05.031
更新日期:2007-01-15 00:00:00
abstract:BACKGROUND:Variations in cerebrospinal fluid (CSF) levels of the monoamine metabolites 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, and homovanillic acid have been associated with behavioral abnormalities in nonhuman primates, and with psychopathology in studies of children and adults. METHODS:We assay...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/s0006-3223(98)00170-x
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Marked interindividual differences in vulnerability to nicotine dependence exist, but factors underlying such differences are not well understood. The midbrain alpha4beta2* subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediation of the reinforcing effects of nicotine responsibl...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2008.09.036
更新日期:2009-04-15 00:00:00
abstract::Smooth pursuit eye movements (SPEM) for two stimulus velocities (sinusoidal and triangular) were studied by visual inspection in 12 unmedicated RDC-diagnosed schizophrenic patients and in 13 matched controls. SPEM was worse in the patient group and their performance deteriorated with repeated presentations of the task...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Decreased hippocampal volume is observed in patients with Cushing's syndrome and other conditions associated with elevated cortisol levels, stress, or both. Reversibility of hippocampal neuronal atrophy resulting from stress occurs in animals. Our study investigated the potential for reversibility of human h...
journal_title:Biological psychiatry
pub_type: 临床试验,杂志文章
doi:10.1016/s0006-3223(99)00203-6
更新日期:1999-12-15 00:00:00
abstract:BACKGROUND:Subjects with autism suffer from impairments of social interaction, deviations in language usage, as well as restricted and stereotyped patterns of behavior. These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose ...
journal_title:Biological psychiatry
pub_type: 杂志文章
doi:10.1016/j.biopsych.2011.03.026
更新日期:2011-08-01 00:00:00
abstract::The recent deliberations by the U.S. Food and Drug Administration (FDA) regarding the relationship between antidepressants and suicidality in children have incited debates about the safety of these medications for the treatment of pediatric depression. In light of these events, this review discusses four issues pertai...
journal_title:Biological psychiatry
pub_type: 杂志文章,评审
doi:10.1016/j.biopsych.2005.10.010
更新日期:2006-06-01 00:00:00